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    Extract of Fraxinus excelsior seeds and therapeutic applications therefor
    6.
    发明授权
    Extract of Fraxinus excelsior seeds and therapeutic applications therefor 有权
    Fraxinus提取物优良种子及其治疗应用

    公开(公告)号：US08293292B2

    公开(公告)日：2012-10-23

    申请号：US13294058

    申请日：2011-11-10

    申请人： Kan He ,  Marc Roller ,  Antoine Bily ,  Naisheng Bai ,  Jacques DiKansky ,  Alvin Ibarra

    发明人： Kan He ,  Marc Roller ,  Antoine Bily ,  Naisheng Bai ,  Jacques DiKansky ,  Alvin Ibarra

    IPC分类号： A61K36/63

    CPC分类号： A61K36/63 ,  A61K31/7088

    摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S)2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

    摘要翻译： 可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平与高胰岛素血症的关系，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者（包括人）的Fraxinus excelsior种子提取物 引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O- [b] -D-吡喃葡萄糖基 - D-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基 - 2 - [（6-O-和bgr-D-吡喃葡萄糖基-β-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯，通常称为excelside B ，和化合物GI5，GI3，硝酸ide酯和油甙二甲酯。

    Extract of Lepidium meyenii roots for pharmaceutical applications
    9.
    发明授权
    Extract of Lepidium meyenii roots for pharmaceutical applications 有权
    用于制药应用的梅毒根提取物

    公开(公告)号：US06267995B1

    公开(公告)日：2001-07-31

    申请号：US09261806

    申请日：1999-03-03

    申请人： Bo Lin Zheng ,  Calvin Hyungchan Kim ,  Stephen Wolthoff ,  Kan He ,  Lingling Rogers ,  Yu Shao ,  Qun Yi Zheng

    发明人： Bo Lin Zheng ,  Calvin Hyungchan Kim ,  Stephen Wolthoff ,  Kan He ,  Lingling Rogers ,  Yu Shao ,  Qun Yi Zheng

    IPC分类号： A61K3578

    CPC分类号： A61K36/31

    摘要： An isolated composition obtained by extracting Lepidium meyenii roots is provided. The composition is substantially free of cellulose and comprises between about 5% and about 9% of benzyl isothiocyanate, between about 1% and about 3% of Lepidium sterol component, between about 20% and about 30% of Lepidium fatty acid component, and about 10% or more of macamide component. The composition is prepared by a process which comprises contacting Lepidium meyenii roots with a first aqueous solvent of about 90% vol-% or more water, then separating the residual Lepidium meyenii root material from the first contacted aqueous solvent, then contacting the residual Lepidium meyenii root material with a second aqueous solvent which comprises a mixture of an alcohol and water having about 90 vol-% alcohol or more to form a liquor, and then finally concentrating the liquor to obtain the composition. The composition can be used for treating cancer and sexual dysfunction.

    摘要翻译： 提供了通过提取梅毒根获得的分离组合物。 所述组合物基本上不含纤维素，并且包含约5％至约9％的异硫氰酸苄酯，约1％至约3％的Lepidium sterol组分，约20％至约30％的Lepidium脂肪酸组分和约 10％以上的macamide成分。 组合物通过以下方法制备，该方法包括使梅毒根与约90％体积％或更多的水的第一含水溶剂接触，然后从残留的第一次接触的水性溶剂中分离剩余的梅毒根部物质，然后将剩余的梅毒 根部材料与第二含水溶剂组成，其包含具有约90体积％醇或更多醇的醇和水的混合物以形成液体，然后最终将液体浓缩以获得组合物。 该组合物可用于治疗癌症和性功能障碍。

    Extract Of Fraxinus Excelsior Seeds And Therapeutic Applications Therefor
    10.
    发明申请
    Extract Of Fraxinus Excelsior Seeds And Therapeutic Applications Therefor 有权
    Fraxinus Excelsior种子提取物及其治疗应用

    公开(公告)号：US20090117214A1

    公开(公告)日：2009-05-07

    申请号：US12185649

    申请日：2008-08-04

    申请人： Kan He ,  Marc Roller ,  Antonie Bily ,  Naisheng Bai ,  Jacques Dikansky ,  Alvin Ibarra

    发明人： Kan He ,  Marc Roller ,  Antonie Bily ,  Naisheng Bai ,  Jacques Dikansky ,  Alvin Ibarra

    IPC分类号： A61K36/63 ,  A61K31/7088 ,  A61P3/00 ,  C07G3/00

    CPC分类号： A61K36/63 ,  A61K31/7088

    摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds G15, G13, nuzhenide, and oleoside dimethyl ester.

    摘要翻译： 可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平与高胰岛素血症的关系，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者（包括人）的Fraxinus excelsior种子提取物 引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O-β-D-吡喃葡萄糖基-β-D - 吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2- 氧基] -3,4-二氢-5-（甲氧基羰基）-2-（4-羟基苯基）乙酯（通常称为excelside B）的化合物和化合物（6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） G15，G13，nunzhenide和油脂二甲酯。