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    Methods and Apparatus for Sclerosing the Wall of a Varicose Vein
    2.
    发明申请
    Methods and Apparatus for Sclerosing the Wall of a Varicose Vein 有权
    用于硬化静脉曲张壁的方法和装置

    公开(公告)号：US20060189930A1

    公开(公告)日：2006-08-24

    申请号：US11381372

    申请日：2006-05-03

    申请人： Banning Lary ,  Leonard Pinchuk ,  Saul Gottlieb ,  Charles Slater

    发明人： Banning Lary ,  Leonard Pinchuk ,  Saul Gottlieb ,  Charles Slater

    IPC分类号： A61M29/00

    CPC分类号： A61M25/10 ,  A61B17/320725 ,  A61B2017/22038 ,  A61B2017/22067 ,  A61B2017/22082 ,  A61M25/1011 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1068

    摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.

    摘要翻译： 用于将诸如硬化剂（或微泡硬化剂）的血管内药物递送到静脉曲张的优选装置包括具有三个同心管的导管。 最内管具有导丝管腔和充气腔。 最内管的远端具有与膨胀腔流体连通的整体充气闭塞球囊。 中间管具有内管，最内管延伸通过该内腔。 中间管的远端具有自膨胀气囊，其具有与中间管腔流体连通的多个流体孔。 外管具有中空管延伸通过的内腔。 硬化剂通过中间管分配到位于中间管的远端或自膨胀气囊中的孔。 静脉由于自膨胀的气囊被拉过并最终脱离静脉，因此是硬化的。

    Apparatus for delivering an intravascular drug
    4.
    发明授权
    Apparatus for delivering an intravascular drug 有权
    用于输送血管内药物的装置

    公开(公告)号：US07985200B2

    公开(公告)日：2011-07-26

    申请号：US11381372

    申请日：2006-05-03

    申请人： Banning G. Lary ,  Leonard Pinchuk ,  Saul Gottlieb ,  Charles R. Slater

    发明人： Banning G. Lary ,  Leonard Pinchuk ,  Saul Gottlieb ,  Charles R. Slater

    IPC分类号： A61M29/00

    CPC分类号： A61M25/10 ,  A61B17/320725 ,  A61B2017/22038 ,  A61B2017/22067 ,  A61B2017/22082 ,  A61M25/1011 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1068

    摘要： A preferred apparatus for delivering an intravascular drug such as a sclerosing agent (or a microfoam sclerosing agent) to a varicose vein includes a catheter having three concentric tubes. The innermost tube has a guide wire lumen and an inflation lumen. The distal end of the innermost tube has an integral inflatable occlusion balloon in fluid communication with the inflation lumen. The intermediate tube has a lumen through which the innermost tube extends. The distal end of the intermediate tube has a self-expanding balloon with a plurality of fluid pores in fluid communication with the intermediate tube lumen. The outer tube has a lumen through which the intermediate tube extends. Sclerosing agent is dispensed through the intermediate tube to pores located at the distal end of the intermediate tube or in the self-expanding balloon. Veins are sclerosed as the self-expanding balloon is pulled through and ultimately out of the vein.

    摘要翻译： 用于将诸如硬化剂（或微泡硬化剂）的血管内药物递送到静脉曲张的优选装置包括具有三个同心管的导管。 最内管具有导丝管腔和充气腔。 最内管的远端具有与膨胀腔流体连通的整体充气闭塞球囊。 中间管具有内管，最内管延伸通过该内腔。 中间管的远端具有自膨胀气囊，其具有与中间管腔流体连通的多个流体孔。 外管具有中空管延伸通过的内腔。 硬化剂通过中间管分配到位于中间管的远端或自膨胀气囊中的孔。 静脉由于自膨胀的气囊被拉过并最终脱离静脉，因此是硬化的。

    Glaucoma implant device
    5.
    发明授权
    Glaucoma implant device 有权
    青光眼植入装置

    公开(公告)号：US07431709B2

    公开(公告)日：2008-10-07

    申请号：US11004539

    申请日：2004-12-03

    申请人： Leonard Pinchuk ,  Jean-Marie Parel ,  Francisco Fantes ,  Saul Gottlieb ,  John B. Martin, Jr. ,  Yasushi Pedro Kato

    发明人： Leonard Pinchuk ,  Jean-Marie Parel ,  Francisco Fantes ,  Saul Gottlieb ,  John B. Martin, Jr. ,  Yasushi Pedro Kato

    IPC分类号： A61M5/00 ,  A61K9/22 ,  A61M31/00

    CPC分类号： A61F9/00781 ,  A61F2210/0071

    摘要： A surgical implant device for treating glaucoma includes an elongate duct structure formed from a material comprising polyisobutylene and a glassy segment. The material of the elongate duct structure preferably has a general block structure with a central elastomeric polyolefinic block and thermoplastic end blocks (e.g., a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The elongate duct structure provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. Preferably, the elongate duct structure defines a lumen channel having an inside diameter between 0.05 mm and 0.3 mm. The material of the elongate duct structure is biocompatible and biostable. Moreover, the material will not encapsulate in the eye and thus provides an unobstructed flowpath that diverts aqueous humor from the anterior chamber. Different embodiments of the implant device divert the aqueous humor to different parts of the eye (e.g., a space between the conjuctiva and sclera, Schlemm's canal, or a fluid reservoir formed on a posterior surface of the eye).

    摘要翻译： 用于治疗青光眼的手术植入装置包括由包含聚异丁烯和玻璃状段的材料形成的细长管道结构。 细长管道结构的材料优选具有中央弹性聚烯烃嵌段和热塑性端嵌段（例如，包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）的通用嵌段结构。 细长的管道结构提供用于将房水从眼睛的前房转向的流体通道。 优选地，细长管道结构限定了具有在0.05mm和0.3mm之间的内径的管腔通道。 细长管道结构的材料是生物相容性和生物稳定性。 此外，该材料将不会包封在眼睛中，从而提供将房水从前房转移的畅通的流路。 植入装置的不同实施例将房水转移到眼睛的不同部分（例如，结膜和巩膜之间的空间，施莱姆氏管或形成在眼后表面上的流体储存器）。

    Glaucoma implant device
    6.
    发明申请
    Glaucoma implant device 有权
    青光眼植入装置

    公开(公告)号：US20050125003A1

    公开(公告)日：2005-06-09

    申请号：US11004539

    申请日：2004-12-03

    申请人： Leonard Pinchuk ,  Jean-Marie Parel ,  Francisco Fantes ,  Saul Gottlieb ,  John Martin ,  Yasushi Kato

    发明人： Leonard Pinchuk ,  Jean-Marie Parel ,  Francisco Fantes ,  Saul Gottlieb ,  John Martin ,  Yasushi Kato

    IPC分类号： A61F2/00 ,  A61F9/007

    CPC分类号： A61F9/00781 ,  A61F2210/0071

    摘要： A surgical implant device for treating glaucoma includes an elongate duct structure formed from a material comprising polyisobutylene and a glassy segment. The material of the elongate duct structure preferably has a general block structure with a central elastomeric polyolefinic block and thermoplastic end blocks (e.g., a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The elongate duct structure provides a fluid passageway for diverting aqueous humor from the anterior chamber of the eye. Preferably, the elongate duct structure defines a lumen channel having an inside diameter between 0.05 mm and 0.3 mm. The material of the elongate duct structure is biocompatible and biostable. Moreover, the material will not encapsulate in the eye and thus provides an unobstructed flowpath that diverts aqueous humor from the anterior chamber. Different embodiments of the implant device divert the aqueous humor to different parts of the eye (e.g., a space between the conjuctiva and sclera, Schlemm's canal, or a fluid reservoir formed on a posterior surface of the eye).

    摘要翻译： 用于治疗青光眼的手术植入装置包括由包含聚异丁烯和玻璃状段的材料形成的细长管道结构。 细长管道结构的材料优选具有中央弹性聚烯烃嵌段和热塑性端嵌段（例如，包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）的通用嵌段结构。 细长的管道结构提供用于将房水从眼睛的前房转向的流体通道。 优选地，细长管道结构限定了具有在0.05mm和0.3mm之间的内径的管腔通道。 细长管道结构的材料是生物相容性和生物稳定性。 此外，该材料将不会包封在眼睛中，从而提供将房水从前房转移的畅通的流路。 植入装置的不同实施例将房水转移到眼睛的不同部分（例如，结膜和巩膜之间的空间，施莱姆氏管或形成在眼后表面上的流体储存器）。