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公开(公告)号：US10251781B2
公开(公告)日：2019-04-09
申请号：US14006082
申请日：2012-03-20
摘要： A method for refilling a lens of an eye or increasing the elasticity of a lens of an eye includes removing a central portion of the lens core through the eye's cornea, a capsulorhexis in the eye's lens capsule and a gullet extending at least partially through the cortex of the lens. The lens is then refilled with a synthetic lens material. Sufficient lens core is left in place so that the synthetic material is not in contact with a lens capsule of the eye. The synthetic material used for refilling may be selected and may be formed in a shape and thickness so as to affect the refractive characteristics of the lens. An endocapsular lenticule may be inserted in the lens to affect the refractive characteristics of the lens.
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2.发明申请INTRAOPERATIVE MONITORING OF TEMPERATURE-INDUCED TISSUE CHANGES WITH A HIGH-RESOLUTION DIGITAL X-RAY SYSTEM DURING THERMOTHERAPY 失效用THERMOTHERAPY进行高分辨数字X射线系统的温度诱导组织变化的手术监测公开(公告)号：US20120101375A1
公开(公告)日：2012-04-26
申请号：US13289709
申请日：2011-11-04
申请人： Jean-Marie Parel , Fabrice Manns , David S. Robinson , Peter Milne , David B. Denham , Xochitl Gonzalez-Cirre
发明人： Jean-Marie Parel , Fabrice Manns , David S. Robinson , Peter Milne , David B. Denham , Xochitl Gonzalez-Cirre
IPC分类号： A61B6/00
CPC分类号： A61N5/0601 , A61B5/015 , A61B6/583 , A61B2017/00084 , A61B2018/2005
摘要： A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting portions of the first beam that passed through the volume, generating a first image signal from the portions of the first beam detected, applying heat to at least a localized region of tissue within the volume after the illuminating and detecting, illuminating the volume with a second beam of X-rays, detecting portions of the second beam that passed through the volume during the illuminating with the second beam, generating a second image signal from the portions of the second beam detected, and generating a difference image signal based upon a comparison of the first and second image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume due to the application of heat.
摘要翻译： 一种热诱导和监测对组织的局部区域的变化的方法，其利用第一射线束X射线照射一定体积的组织，检测穿过该体积的第一束的部分，从第一束的部分产生第一图像信号 检测到光束，在照射和检测之后，将热量施加到体积内的组织的至少局部区域，用第二射线束照射体积，检测在照射期间通过体积的第二束的部分， 第二光束，从所检测的第二光束的部分产生第二图像信号，并且基于第一和第二图像信号的比较产生差分图像信号。 差分图像信号由于施加热量而提供体积内组织的局部区域的X射线衰减变化的信息。
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公开(公告)号：US20090312749A1
公开(公告)日：2009-12-17
申请号：US11991343
申请日：2005-08-30
CPC分类号： A61F9/0008 , A61B2017/00508 , A61F9/0017 , A61F9/00736 , A61F9/008 , A61F13/00 , A61F2002/30062 , A61F2009/00863 , A61F2009/0087 , A61F2009/00872 , A61F2009/00887 , A61F2009/00889
摘要： A method of suturing the lens capsule of the eye in the event of accidental rupture thereof or to create a valve and/or to close a capsulorhexis by laser-induced welding onto the capsule's surface of a flap of biocompatible biological tissue prepared so as to be optically absorbent at the wavelength of the laser being used for welding. The method is suitable for use in so-called Phaco-Ersatz or “lens refilling” ophthalmologic surgery. Welding is desirably performed using laser devices that comprise a laser generator and a fiberoptic system for conveying the laser beam, complete with an applicator handpiece suitable for use in welding the flaps onto the lens capsule in a liquid environment. The handpiece is shaped so as to exert moderate pressure on the tissues to be welded with the free end of the optic fiber.
摘要翻译： 在眼睛的意外破裂的情况下缝合眼睛的晶状体胶囊的方法或通过激光诱导的焊接产生瓣膜和/或封闭胶囊切开术的方法，所述胶囊的生物相容性生物组织的皮瓣的表面被制备成为 在用于焊接的激光波长下光学吸收。 该方法适用于所谓的Phaco-Ersatz或“镜片补充”眼科手术。 期望地使用包括激光发生器和用于传送激光束的光纤系统的激光装置进行焊接，其中包括适用于在液体环境中将襟翼焊接到透镜胶囊上的施加器手柄。 手柄的形状使得在与光纤的自由端焊接的组织上施加适度的压力。
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公开(公告)号：US20070123812A1
公开(公告)日：2007-05-31
申请号：US11561960
申请日：2006-11-21
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61F2210/0071
摘要： A surgical method is provided for diverting aqueous humor from the anterior chamber of the eye. A surgical tool is provided having a hollow support member that supports a portion of an aqueous humor drainage device. The device has an elongate duct structure and preferably at least one fixation member that extends therefrom. The distal end of the hollow support member is inserted into the anterior chamber of the eye through an opening passing through the sclera. The aqueous humor drainage device is deployed from the hollow support member for placement into the eye. In one embodiment, the fixation member is realized by a tab that is spaced apart from the two ends of the elongate duct structure. In another embodiment, the fixation member is realized by a pair of tines that extend in traverse directions relative to the central axis of the elongate duct structure.
摘要翻译： 提供了一种手术方法，用于将房水从眼睛的前房转移。 提供具有中空支撑构件的手术工具，所述中空支撑构件支撑房水引流装置的一部分。 该装置具有细长的管道结构，优选地至少一个从其延伸的固定构件。 中空支撑构件的远端通过穿过巩膜的开口插入眼睛的前房。 房水引流装置从中空支撑构件展开以放置到眼睛中。 在一个实施例中，固定构件通过与细长管道结构的两个端部间隔开的突片来实现。 在另一个实施例中，固定构件通过相对于细长管道结构的中心轴线在横向方向上延伸的一对尖齿实现。
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公开(公告)号：US06358279B1
公开(公告)日：2002-03-19
申请号：US09510372
申请日：2000-02-22
申请人： Hassan Tahi , Jean-Marie Parel , Pascal Chapon
发明人： Hassan Tahi , Jean-Marie Parel , Pascal Chapon
IPC分类号： A61F214
CPC分类号： A61F2/1613 , A61F2/1635 , A61F9/007 , A61F9/00736 , A61F9/00754
摘要： A mini capsulorhexis valve device is composed of a curved, flexible discoid flap-valve member shaped to align with an ocular lens capsular bag inner surface, and a curved, flexible retainer member shaped to align with an ocular lens capsular bag outer surface, the curved, flexible retainer member being attached at a fastening point to the curved, flexible discoid flap-valve member. Attachment of the curved, flexible discoid flap-valve member to the curved, flexible retainer member may be via bonding with a silastic adhesive. In a method of accessing an ocular lens, the mini capsulorhexis valve device establishes a portal controlling access to an ocular lens. The method may include inserting a cannula through the mini capsulorhexis valve device to permit removal of a crystalline lens matrix and replacement thereof with a capsular filling material. The method may also include injecting a cytotoxic agent into a lens capsule, during which leakage of the injected cytotoxic agent is prevented by the mini capsulorhexis valve device. The method may further include adjusting the refractive power of capsular filling material by adding or removing capsular filling material from the lens capsule during lens replacement surgery or post-surgically.
摘要翻译： 迷你撕囊阀装置由弯曲的柔性圆盘形瓣阀构件组成，其形状与眼镜片囊袋内表面对准，并且弯曲的柔性保持构件成形为与眼镜片囊袋外表面对准，弯曲 柔性保持构件在紧固点处附接到弯曲的柔性圆盘形瓣阀构件。 弯曲的柔性圆盘形瓣阀构件附接到弯曲的柔性保持器构件可以通过与硅橡胶粘合剂的粘合。 在接近眼透镜的方法中，迷你薄膜切开阀装置建立门禁控制对眼透镜的通路。 该方法可以包括通过迷你型撕囊阀装置插入套管以允许移除晶状体基质并用囊状填充材料替换。 该方法还可以包括将细胞毒性剂注射到晶状体囊中，在此期间，通过迷你薄膜截止阀装置防止注射的细胞毒性剂的泄漏。 该方法还可以包括通过在镜片置换手术期间或手术后添加或去除晶状体囊的囊状填充材料来调节囊状填充材料的屈光力。
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公开(公告)号：US08795262B2
公开(公告)日：2014-08-05
申请号：US11991343
申请日：2005-08-30
CPC分类号： A61F9/0008 , A61B2017/00508 , A61F9/0017 , A61F9/00736 , A61F9/008 , A61F13/00 , A61F2002/30062 , A61F2009/00863 , A61F2009/0087 , A61F2009/00872 , A61F2009/00887 , A61F2009/00889
摘要： A method of suturing the lens capsule of the eye in the event of accidental rupture thereof or to create a valve and/or to close a capsulorhexis by laser-induced welding onto the capsule's surface of a flap of biocompatible biological tissue prepared so as to be optically absorbent at the wavelength of the laser being used for welding. The method is suitable for use in so-called Phaco-Ersatz or “lens refilling” ophthalmologic surgery. Welding is desirably performed using laser devices that comprise a laser generator and a fiberoptic system for conveying the laser beam, complete with an applicator handpiece suitable for use in welding the flaps onto the lens capsule in a liquid environment. The handpiece is shaped so as to exert moderate pressure on the tissues to be welded with the free end of the optic fiber.
摘要翻译： 在眼睛的意外破裂的情况下缝合眼睛的晶状体胶囊的方法或通过激光诱导的焊接产生瓣膜和/或封闭胶囊切开术的方法，所述胶囊的生物相容性生物组织的皮瓣的表面被制备成为 在用于焊接的激光波长下光学吸收。 该方法适用于所谓的Phaco-Ersatz或“镜片补充”眼科手术。 期望地使用包括激光发生器和用于传送激光束的光纤系统的激光装置进行焊接，其中包括适用于在液体环境中将襟翼焊接到透镜胶囊上的施加器手柄。 手柄的形状使得在与光纤的自由端焊接的组织上施加适度的压力。
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7.发明授权Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital X-ray system during thermotherapy 失效在热疗期间用高分辨率数字X射线系统进行温度诱导组织变化的术中监测公开(公告)号：US08099147B2
公开(公告)日：2012-01-17
申请号：US12081278
申请日：2008-04-14
申请人： Jean-Marie Parel , Fabrice Manns , David S. Robinson , Peter Milne , David B. Denham , Xochitl Gonzalez-Cirre
发明人： Jean-Marie Parel , Fabrice Manns , David S. Robinson , Peter Milne , David B. Denham , Xochitl Gonzalez-Cirre
IPC分类号： A61B5/00
CPC分类号： A61N5/0601 , A61B5/015 , A61B6/583 , A61B2017/00084 , A61B2018/2005
摘要： A method of thermally inducing and monitoring changes to localized regions of tissue illuminating a volume of tissue with a first beam of X-rays, detecting the portions of the first beam of X-rays that passed through the volume of tissue, generating a first X-ray image signal from the portions of X10 rays of the first beam detected, applying heat to at least a localized region of tissue within the volume of tissue after the illuminating and after the detecting, illuminating the volume of tissue with a second beam of X-rays, detecting portions of the second beam of X-rays that passed through the volume of tissue during the illuminating with the second beam of X-rays, generating a second X-ray image signal from the portions of X-rays of the second beam detected, and generating a difference image signal based upon a comparison of the first and second X-ray image signals. The difference image signal provides information of changes in X-ray attenuation by localized regions of tissue within the volume of tissue due to the application of heat.
摘要翻译： 一种热诱导和监测对组织的局部区域的变化的方法，用第一束X射线照射一定体积的组织，检测穿过组织体积的X射线的第一束束的部分，产生第一X 检测到的来自第一光束的X10射线的部分的图像信号，在照射之后并且在检测之后，将热量施加到组织体内的组织的至少局部区域，并用第二光束X照射组织的体积 检测在用第二光束X射线照射期间通过组织体积的第二X射线束的部分，从第二X射线的X射线的部分产生第二X射线图像信号 并且基于第一和第二X射线图像信号的比较产生差分图像信号。 差分图像信号由于施加热量而提供组织体内的组织的局部区域的X射线衰减的变化信息。
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公开(公告)号：US20060116761A1
公开(公告)日：2006-06-01
申请号：US11337716
申请日：2006-01-23
申请人： William Lee , Viviana Fernandez , Jean-Marie Parel , Arthur Ho
发明人： William Lee , Viviana Fernandez , Jean-Marie Parel , Arthur Ho
CPC分类号： A61F9/007
摘要： A one-piece capsulorhexis device is presented comprising a membrane having a curved, flexible substantially discoid flap-valve member shaped to align with an ocular lens capsular bag inner surface, and at least one integral, flexible retainer shaped to align with an ocular lens capsular bag outer surface.
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公开(公告)号：US07001426B2
公开(公告)日：2006-02-21
申请号：US10298964
申请日：2002-11-18
申请人： William Lee , Viviana Fernandez , Jean-Marie Parel , Arthur Ho
发明人： William Lee , Viviana Fernandez , Jean-Marie Parel , Arthur Ho
IPC分类号： A61F2/14
CPC分类号： A61F9/007
摘要： A one-piece capsulorhexis device is presented comprising a membrane having a curved, flexible substantially discoid flap-valve member shaped to align with an ocular lens capsular bag inner surface, and at least one integral, flexible retainer shaped to align with an ocular lens capsular bag outer surface.
摘要翻译： 提供了一种单件式撕囊装置，其包括膜，其具有弯曲的，柔性的基本上盘形的瓣形构件，其成形为与眼镜片囊袋内表面对准，以及至少一个整体的柔性保持器，其形状与眼镜片囊 袋外表面。
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公开(公告)号：US20050125059A1
公开(公告)日：2005-06-09
申请号：US11004538
申请日：2004-12-03
申请人： Leonard Pinchuk , Jean-Marie Parel
发明人： Leonard Pinchuk , Jean-Marie Parel
IPC分类号： A61F2/16 , A61F9/00 , A61L27/16 , G02C20060101
CPC分类号： A61L27/16 , A61F2/1613 , A61F2/1629 , A61F2/1648 , A61F9/0017 , A61F2250/0067 , A61L27/54 , A61L2300/416 , A61L2430/16 , G02B1/041 , C08L53/02 , C08L23/22 , C08L25/08
摘要： An ocular lens has a refractive optics structure formed from a polyisobutylene-based material and a glassy segment that is non-reactive to ocular fluid and that maintains in vivo transparency for a substantial time period. The material has a central elastomeric polyolefinic block and thermoplastic end blocks (such as a triblock polymer backbone comprising polystyrene-polyisobutylene-polystyrene). The material is preferably flexible such that the refractive optics structure can be folded upon itself and introduced through a small scleral incision. The lens device includes an optic portion and preferably either an annular haptic element or one or more haptic elements adapted to rest within a capsular bag formed by a surgical procedure. A portion of the lens device may be loaded with at least one therapeutic agent that interferes with proliferation of the epithelial cells of the eye to protect against PCO.
摘要翻译： 眼透镜具有由聚异丁烯基材料形成的折射光学结构和与眼液无反应性的玻璃质片段，并且在相当长的时间内维持体内透明度。 该材料具有中心弹性聚烯烃嵌段和热塑性端嵌段（例如包含聚苯乙烯 - 聚异丁烯 - 聚苯乙烯的三嵌段聚合物主链）。 该材料优选是柔性的，使得折射光学结构可以自身折叠并通过小的巩膜切口引入。 透镜装置包括光学部分，并且优选地是环形触觉元件或适于搁置在通过外科手术形成的囊袋内的一个或多个触觉元件。 透镜装置的一部分可以装载有至少一种治疗剂，其干扰眼睛上皮细胞的增殖以防止PCO。
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