公开(公告)号：US06592733B1

公开(公告)日：2003-07-15

申请号：US09438873

申请日：1999-11-12

申请人： Barbara Foley ,  Jaymie Sawyer ,  Cynthia G. Briscoe

发明人： Barbara Foley ,  Jaymie Sawyer ,  Cynthia G. Briscoe

IPC分类号： G01N2726

CPC分类号： G01N27/44791 ,  G01N27/44721 ,  G01N27/44782

摘要： A capillary electrophoresis device having a substrate layer and a cover layer, with a plurality of electrophoresis channels formed in the substrate layer, includes an optical waveguide system that transmits excitation radiation from a source port into each one of the electrophoresis channels. The optical waveguide system is defined by regions, within either the cover or substrate, that have an index of refraction higher than that of the surrounding material.

摘要翻译： 具有衬底层和覆盖层的毛细管电泳装置，具有形成在衬底层中的多个电泳通道，包括将激发辐射从源端口传输到每个电泳通道中的光波导系统。 光波导系统由覆盖物或衬底内的区域限定，其折射率高于周围材料的折射率。

公开(公告)号：US20050023155A1

公开(公告)日：2005-02-03

申请号：US10203874

申请日：2001-02-20

申请人： Jaymie Sawyer ,  Changming Li ,  Vi-En Choong ,  George Maracas ,  peiming Zhang

发明人： Jaymie Sawyer ,  Changming Li ,  Vi-En Choong ,  George Maracas ,  peiming Zhang

IPC分类号： G01N33/543 ,  G01N1/00 ,  G01N17/00

CPC分类号： G01N33/5438

摘要： The present invention provides an apparatus and methods for the electrical detection of molecular interactions between a probe molecule and a protein or peptide target molecule, but without requiring the use of electrochemical or other reporters to obtain measurable signals. The methods can be used for electrical detection of molecular interactions between probe molecules bound to defined regions of an array and protein or peptide target molecules which are permitted to interact with the probe molecules.

摘要翻译： 本发明提供了用于电探测分子与蛋白质或肽靶分子之间的分子相互作用的装置和方法，但不需要使用电化学或其他记录来获得可测量的信号。 该方法可用于电子检测结合到阵列的限定区域的探针分子与允许与探针分子相互作用的蛋白质或肽靶分子之间的分子相互作用。