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公开(公告)号:US06592733B1
公开(公告)日:2003-07-15
申请号:US09438873
申请日:1999-11-12
申请人: Barbara Foley , Jaymie Sawyer , Cynthia G. Briscoe
发明人: Barbara Foley , Jaymie Sawyer , Cynthia G. Briscoe
IPC分类号: G01N2726
CPC分类号: G01N27/44791 , G01N27/44721 , G01N27/44782
摘要: A capillary electrophoresis device having a substrate layer and a cover layer, with a plurality of electrophoresis channels formed in the substrate layer, includes an optical waveguide system that transmits excitation radiation from a source port into each one of the electrophoresis channels. The optical waveguide system is defined by regions, within either the cover or substrate, that have an index of refraction higher than that of the surrounding material.
摘要翻译: 具有衬底层和覆盖层的毛细管电泳装置,具有形成在衬底层中的多个电泳通道,包括将激发辐射从源端口传输到每个电泳通道中的光波导系统。 光波导系统由覆盖物或衬底内的区域限定,其折射率高于周围材料的折射率。
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公开(公告)号:US06960467B2
公开(公告)日:2005-11-01
申请号:US10028277
申请日:2001-12-19
申请人: Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
发明人: Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
IPC分类号: G01N33/53 , B01J19/00 , B01L3/00 , B01L7/00 , B81B1/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/566 , G01N37/00 , C12M3/00
CPC分类号: B01L3/5027 , B01J2219/00317 , B01J2219/00351 , B01J2219/00416 , B01J2219/00418 , B01J2219/00421 , B01J2219/00432 , B01J2219/0052 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L7/525 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/043 , B01L2400/049 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S366/02 , Y10S435/81 , C12Q2565/629
摘要: The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of the invention are fabricated from plastic and are operatively associated with a fluid propelling component and detector.
摘要翻译: 本发明涉及具有微通道的微流体装置,其具有分离的区域,其具有与多孔聚合物结合的特异性结合对成员(例如DNA或RNA),制成微通道的珠粒或结构。 本发明的微通道由塑料制成并且与流体推进部件和检测器可操作地相关联。
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公开(公告)号:US20230064396A1
公开(公告)日:2023-03-02
申请号:US17900443
申请日:2022-08-31
申请人: Barbara Foley , Stephen Foley, III , Ryan Foley
发明人: Barbara Foley , Stephen Foley, III , Ryan Foley
IPC分类号: A47B37/04
摘要: The present disclosure relates to an adjustable table including (i) a base, (ii) a first elongated rod coupled to the base, wherein the first elongated rod includes one or more first through holes, (iii) a second elongated rod configured to translate with respect to the first elongated rod, wherein the second elongated rod includes one or more second through holes, (iv) a table top coupled to the second elongated rod, and (v) a coupling mechanism configured to be positioned between one of the one or more first through holes and one of the one or more second through holes to thereby set a distance between the table top and the base.
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公开(公告)号:US6048699A
公开(公告)日:2000-04-11
申请号:US174605
申请日:1998-10-19
IPC分类号: B01J19/00 , C07B61/00 , C07H21/00 , C40B40/06 , C40B60/14 , H01L51/40 , C12Q1/68 , C07H19/00 , C12N11/00 , H04R1/02
CPC分类号: H01L51/0001 , B01J19/0046 , C07H21/00 , B01J2219/00351 , B01J2219/00362 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00659 , B01J2219/00722 , C07B2200/11 , C40B40/06 , C40B60/14
摘要: A method of fabricating one or more arrays of bio-molecule test sites including providing a solution containing bio-molecule probes in contact with the surface of a substrate, using orthogonal acoustic waves to concentrate the bio-molecule probes at a node intersection, bonding the bio-molecule probes on the substrate at the node intersection to form a test site, and removing the solution leaving the bio-molecule probes attached to the surface at the test site. The steps are repeated as often as desired, using different bio-molecule probes, to produce one or more arrays of test sites.
摘要翻译: 一种制造生物分子测试位点的一个或多个阵列的方法,包括提供含有与衬底表面接触的生物分子探针的溶液,使用正交声波将生物分子探针集中在节点交点处, 生物分子探针在基底上的节点交叉处以形成测试位点,并除去离开生物分子探针的溶液,附着在测试位点的表面。 通过使用不同的生物分子探针,根据需要重复这些步骤以产生一个或多个测试位点阵列。
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公开(公告)号:US5243671A
公开(公告)日:1993-09-07
申请号:US815480
申请日:1991-12-31
申请人: Emil S. Koteles , Paul Melman , Barbara Foley
发明人: Emil S. Koteles , Paul Melman , Barbara Foley
IPC分类号: G02B6/42
CPC分类号: G02B6/4202 , G02B6/4203 , G02B6/4214
摘要: An apparatus for coupling light from a laser chip into an unetched and uncoated optical fiber includes a substrate carrier having a V-groove extending axially through the substrate carrier. The fiber has a beveled end with an inner and outer face and is positionable in the plane of the laser chip within the V-groove such that light emitted by the laser chip strikes the inner face of the beveled end and is totally internally reflected into the fiber core.
摘要翻译: 用于将来自激光芯片的光耦合到未蚀刻和未涂覆的光纤的装置包括具有轴向延伸穿过衬底载体的V形槽的衬底载体。 光纤具有内表面和外表面的倾斜端,并且可在激光芯片的平面内定位在V形槽内,使得由激光芯片发出的光照射到倾斜端的内表面,并且完全内部反射到 纤维芯。
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公开(公告)号:US06361958B1
公开(公告)日:2002-03-26
申请号:US09438600
申请日:1999-11-12
申请人: Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
发明人: Chan-Long Shieh , Barbara Foley , Huinan Yu , Vi-En Choong
IPC分类号: G01N33543
CPC分类号: B01L3/5027 , B01J2219/00317 , B01J2219/00351 , B01J2219/00416 , B01J2219/00418 , B01J2219/00421 , B01J2219/00432 , B01J2219/0052 , B01J2219/00522 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00621 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L7/525 , B01L2300/0636 , B01L2300/0816 , B01L2300/087 , B01L2400/0415 , B01L2400/043 , B01L2400/049 , B82Y30/00 , C12Q1/6834 , C40B40/06 , C40B40/10 , C40B60/14 , Y10S366/02 , Y10S435/81 , C12Q2565/629
摘要: The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads or structures fabricated into the microchannel. The microchannels of the invention are fabricated from plastic and are operatively associated with a fluid propelling component and detector.
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公开(公告)号:US6096172A
公开(公告)日:2000-08-01
申请号:US174606
申请日:1998-10-19
申请人: Barbara Foley , Natalia Briones
发明人: Barbara Foley , Natalia Briones
IPC分类号: G01N33/53 , B01J19/00 , B01J19/12 , C07B61/00 , C12M1/00 , C40B40/06 , C40B40/10 , C40B60/14 , G01N33/543 , G01N33/553 , G01N33/566 , G01N37/00 , C07C1/00 , C12N11/00
CPC分类号: B82Y30/00 , B01J19/0046 , G01N33/54353 , G01N33/553 , B01J2219/00427 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00711 , B01J2219/00713 , B01J2219/00716 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14
摘要: A method of bonding bio-molecules to a test site including providing a substrate having a test site defined on a surface thereof, providing a solution containing a plurality of probe molecules and bonding material, directing light from a light source onto the test site so as to cause the bonding material to bond the probe molecules to the test site.
摘要翻译: 一种将生物分子粘合到测试部位的方法,包括提供在其表面上具有测试部位的基底,提供含有多个探针分子和粘合材料的溶液,将来自光源的光引导到测试部位,以便 以使结合材料将探针分子结合到测试部位。
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