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![Substituted pyrrolo[3,2-c]pyridines as TrkA kinase inhibitors](/abs-image/US/2015/08/11/US09102673B2/abs.jpg.150x150.jpg)
公开(公告)号：US09102673B2
公开(公告)日：2015-08-11
申请号：US14131861
申请日：2012-07-06
申请人： Barbara Hanney , Peter Manley , Michael T. Rudd , John M. Sanders , Shawn J. Stachel , Darrell Henze
发明人： Barbara Hanney , Peter Manley , Michael T. Rudd , John M. Sanders , Shawn J. Stachel , Darrell Henze
IPC分类号： A61K31/437 , C07D471/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/04 , C07D487/04
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/04 , C07D487/04
摘要： The present invention is directed to compounds of formula I and Ia: which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
摘要翻译： 本发明涉及式I和Ia的化合物：它们是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成， 与神经生长因子（NGF）受体TrkA的异常活动相关的疾病，失调，损伤或功能障碍，或与脱髓鞘或脱髓鞘相关的疾病或病症。
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公开(公告)号：US20140155413A1
公开(公告)日：2014-06-05
申请号：US14131861
申请日：2012-07-06
申请人： Barbara Hanney , Peter Manley , Michael T. Rudd , John M. Sanders , Shawn J. Stachel , Darrell Henze
发明人： Barbara Hanney , Peter Manley , Michael T. Rudd , John M. Sanders , Shawn J. Stachel , Darrell Henze
IPC分类号： C07D471/04 , C07D417/04 , C07D401/04 , C07D405/04 , C07D487/04 , C07D403/04
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D417/04 , C07D487/04
摘要： The present invention is directed to compounds of formula I and 1a: which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
摘要翻译： 本发明涉及式I和1a的化合物：其是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成， 与神经生长因子（NGF）受体TrkA的异常活动相关的疾病，失调，损伤或功能障碍，或与脱髓鞘或脱髓鞘相关的疾病或病症。
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公开(公告)号：US07569589B2
公开(公告)日：2009-08-04
申请号：US11188466
申请日：2005-07-25
申请人： Mark T. Bilodeau , Christopher J. Dinsmore , Jeffrey M. Bergman , B. Wesley Trotter , Lou Anne Neilson , Zhicai Wu , Peter Manley , John Hartnett
发明人： Mark T. Bilodeau , Christopher J. Dinsmore , Jeffrey M. Bergman , B. Wesley Trotter , Lou Anne Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC分类号： C07D403/14 , A61K31/44
CPC分类号： C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。
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公开(公告)号：US20080090794A1
公开(公告)日：2008-04-17
申请号：US11658114
申请日：2005-07-27
申请人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza
发明人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza
IPC分类号： A61K31/5377 , A61K31/397 , A61K31/438 , A61K31/4412 , A61K31/4439 , A61P9/04 , C07D213/04 , C07D221/20 , C07D401/14 , C07D413/02 , C07D413/00 , C07D401/02 , C07D213/63 , A61P9/06 , A61P9/00 , A61K31/444 , A61K31/497 , A61K31/506
CPC分类号： C07D213/36 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/64 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。
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公开(公告)号：US20050222155A1
公开(公告)日：2005-10-06
申请号：US10510069
申请日：2003-04-04
申请人： Mark Bilodeau , Mark Duggan , John Hartnett , Craig Lindsley , Peter Manley , Zhicai Wu , Zhijian Zhao
发明人： Mark Bilodeau , Mark Duggan , John Hartnett , Craig Lindsley , Peter Manley , Zhicai Wu , Zhijian Zhao
IPC分类号： C07D333/56 , A61K31/138 , A61K31/337 , A61K31/4535 , A61K31/4545 , A61K31/4709 , A61K31/498 , A61K31/4985 , A61K31/52 , A61K31/706 , A61K45/00 , A61P5/30 , A61P9/14 , A61P35/00 , A61P43/00 , C07D305/14 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D519/00 , C07H5/06 , C07H17/02 , C07D215/12
CPC分类号： C07D401/10 , A61K31/498 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D409/14 , C07D417/14 , C07D471/04
摘要： The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
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公开(公告)号：US08148535B2
公开(公告)日：2012-04-03
申请号：US12083475
申请日：2006-10-17
申请人： B. Wesley Trotter , Kausik K. Nanda , Scott Wolkenberg , M. Brad Nolt , Peter Manley , Nathan R. Kett , Mark T. Bilodeau
发明人： B. Wesley Trotter , Kausik K. Nanda , Scott Wolkenberg , M. Brad Nolt , Peter Manley , Nathan R. Kett , Mark T. Bilodeau
IPC分类号： C07D401/14 , A61K31/4402 , A61K31/4406 , A61K31/4409
CPC分类号： C07D401/14 , C07D213/38 , C07D213/57 , C07D213/74
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。
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公开(公告)号：US20060030595A1
公开(公告)日：2006-02-09
申请号：US11188466
申请日：2005-07-25
申请人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
发明人： Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC分类号： A61K31/506 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号： C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号：US20090233897A1
公开(公告)日：2009-09-17
申请号：US12083475
申请日：2006-10-17
申请人： B. Wesley Trotter , Kausik K. Nanda , Scott Wolkenberg , M. Brad Nolt , Peter Manley , Nathan R. Kett , Mark T. Bilodeau
发明人： B. Wesley Trotter , Kausik K. Nanda , Scott Wolkenberg , M. Brad Nolt , Peter Manley , Nathan R. Kett , Mark T. Bilodeau
IPC分类号： A61K31/444 , C07D401/14 , C07D401/06
CPC分类号： C07D401/14 , C07D213/38 , C07D213/57 , C07D213/74
摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号：US20070254901A1
公开(公告)日：2007-11-01
申请号：US11659606
申请日：2005-08-19
申请人： Mark Bilodeau , Nicolas Cosford , John Hartnett , Yiwei Li , Jun Liang , Peter Manley , Lou Neilson , Tony Siu , Zhicai Wu
发明人： Mark Bilodeau , Nicolas Cosford , John Hartnett , Yiwei Li , Jun Liang , Peter Manley , Lou Neilson , Tony Siu , Zhicai Wu
IPC分类号： A61K31/519 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
摘要翻译： 本发明涉及含有抑制Akt（丝氨酸/苏氨酸蛋白激酶）活性的取代的5-取代哌啶部分的化合物。 本发明还涉及含有本发明化合物的治疗组合物和治疗癌症的方法，包括施用本发明化合物。
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