公开(公告)号：US20060142360A1

公开(公告)日：2006-06-29

申请号：US11209186

申请日：2005-08-22

申请人： Barry Lloyd Potter ,  Lok Wai Woo ,  Atul Purohit ,  Michael Reed ,  Oliver Sutcliffe ,  Christian Bubert

发明人： Barry Lloyd Potter ,  Lok Wai Woo ,  Atul Purohit ,  Michael Reed ,  Oliver Sutcliffe ,  Christian Bubert

IPC分类号： A61K31/4196 ,  C07D249/14 ,  C07D249/08

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D413/12 ,  C07D417/12

摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.

公开(公告)号：US20070105886A1

公开(公告)日：2007-05-10

申请号：US11329982

申请日：2006-01-11

申请人： Barry Victor Potter ,  Michael Reed ,  Lok Wai Woo

发明人： Barry Victor Potter ,  Michael Reed ,  Lok Wai Woo

IPC分类号： C07D221/18 ,  A61K31/473

CPC分类号： C07J1/0051 ,  C07J63/00 ,  C07J63/008

摘要： There is provided a compound having Formula (I) wherein G is H or a substituent, and wherein R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group, capable of inhibiting steroid sulphatase.

摘要翻译： 提供具有式（I）的化合物，其中G是H或取代基，其中R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或 磺胺类，能够抑制类固醇硫酸酯酶。