公开(公告)号：US08466159B2

公开(公告)日：2013-06-18

申请号：US13603022

申请日：2012-09-04

申请人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

发明人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC分类号： A61K31/4965 ,  A61K31/33 ,  A61K31/505 ,  A61K31/47 ,  A61K31/415 ,  A61K31/40

CPC分类号： A61K38/07 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/513 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.

公开(公告)号：US08492386B2

公开(公告)日：2013-07-23

申请号：US13603006

申请日：2012-09-04

申请人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

发明人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC分类号： A61K31/4965 ,  A61K31/33 ,  A61K31/505 ,  A61K31/47 ,  A61K31/415 ,  A61K31/40 ,  A61K31/675

CPC分类号： A61K38/07 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/473 ,  A61K31/513 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/06 ,  A61K38/12 ,  A61K45/06 ,  G06F17/10 ,  G06F19/12

摘要： The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).

公开(公告)号：US20130102558A1

公开(公告)日：2013-04-25

申请号：US13603006

申请日：2012-09-04

申请人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

发明人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC分类号： A61K31/7076 ,  A61K31/497 ,  A61K31/513 ,  A61P31/14 ,  A61K31/4709 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4025 ,  A61K31/7072 ,  A61K31/4725

CPC分类号： A61K38/07 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/473 ,  A61K31/513 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/06 ,  A61K38/12 ,  A61K45/06 ,  G06F17/10 ,  G06F19/12

摘要： The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).

公开(公告)号：US20130102525A1

公开(公告)日：2013-04-25

申请号：US13603022

申请日：2012-09-04

申请人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

发明人： Barry M. Bernstein ,  Rajeev M. Menon ,  Amit Khatri ,  Sven Mensing ,  Sandeep Dutta ,  Daniel E. Cohen ,  Thomas J. Podsadecki ,  Scott C. Brun ,  Walid M. Awni ,  Emily O. Dumas ,  Cheri E. Klein

IPC分类号： A61K31/7056 ,  A61P31/14 ,  A61K38/07

CPC分类号： A61K38/07 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/513 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/05 ,  A61K38/12 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.

公开(公告)号：US20100144795A1

公开(公告)日：2010-06-10

申请号：US12475440

申请日：2009-05-29

申请人： Earle E. Bain ,  Walid M. Abi-Saab ,  Sandeep Dutta ,  Tushar S. Garimella ,  Walid M. Awni ,  Mario D. Saltarelli

发明人： Earle E. Bain ,  Walid M. Abi-Saab ,  Sandeep Dutta ,  Tushar S. Garimella ,  Walid M. Awni ,  Mario D. Saltarelli

IPC分类号： A61K31/4439 ,  A61P25/00

CPC分类号： A61K31/4439

摘要： 3-(5,6-Dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane and salts thereof are effective nicotinic receptor agonist compounds that demonstrated pharmacological effect for symptoms associated with attention-deficit/hyperactivity disorder.

摘要翻译： 3-（5,6-二氯 - 吡啶-3-基）-1S，5S-3,6-二氮杂双环[3.2.0]庚烷及其盐是有效的烟碱受体激动剂化合物，其表现出与注意力相关的症状的药理作用， 缺乏/多动障碍。

公开(公告)号：US08222278B2

公开(公告)日：2012-07-17

申请号：US12475440

申请日：2009-05-29

申请人： Earle E. Bain ,  Walid M. Abi-Saab ,  Sandeep Dutta ,  Tushar S. Garimella ,  Walid M. Awni ,  Mario D. Saltarelli

发明人： Earle E. Bain ,  Walid M. Abi-Saab ,  Sandeep Dutta ,  Tushar S. Garimella ,  Walid M. Awni ,  Mario D. Saltarelli

IPC分类号： A61K31/44

CPC分类号： A61K31/4439

摘要： 3-(5,6-Dichloro-pyridin-3-yl)-1S,5S-3,6-diazabicyclo[3.2.0]heptane and salts thereof are effective nicotinic receptor agonist compounds that demonstrated pharmacological effect for symptoms associated with attention-deficit/hyperactivity disorder.

摘要翻译： 3-（5,6-二氯 - 吡啶-3-基）-1S，5S-3,6-二氮杂双环[3.2.0]庚烷及其盐是有效的烟碱受体激动剂化合物，其表现出与注意力相关的症状的药理作用， 缺乏/多动障碍。

公开(公告)号：US08557239B2

公开(公告)日：2013-10-15

申请号：US12881902

申请日：2010-09-14

申请人： Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Tom C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter Noertersheuser ,  Martin M. Okun

发明人： Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Tom C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter Noertersheuser ,  Martin M. Okun

IPC分类号： A61K39/395

CPC分类号： C07K16/244 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76

摘要： The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

摘要翻译： 本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。

公开(公告)号：US20140079714A1

公开(公告)日：2014-03-20

申请号：US14023590

申请日：2013-09-11

申请人： Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Thomas C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter A. Noertersheuser ,  Martin M. Okun

发明人： Joaquin Mario Valdes ,  Elliot K. Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Kenneth B. Gordon ,  Walid M. Awni ,  Yanjun Bao ,  William G. Glass ,  Yihua Gu ,  Thomas C. Harris ,  Martin Kaul ,  Parvez M. Mulani ,  Peter A. Noertersheuser ,  Martin M. Okun

IPC分类号： C07K16/24

CPC分类号： C07K16/244 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/76

摘要： The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

摘要翻译： 本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者的牛皮癣的方法。