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公开(公告)号：US08466159B2
公开(公告)日：2013-06-18
申请号：US13603022
申请日：2012-09-04
申请人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
发明人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC分类号： A61K31/4965 , A61K31/33 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40
CPC分类号： A61K38/07 , A61K31/402 , A61K31/4025 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/4709 , A61K31/497 , A61K31/513 , A61K31/675 , A61K31/7056 , A61K31/7072 , A61K38/05 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
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公开(公告)号：US08492386B2
公开(公告)日：2013-07-23
申请号：US13603006
申请日：2012-09-04
申请人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
发明人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC分类号： A61K31/4965 , A61K31/33 , A61K31/505 , A61K31/47 , A61K31/415 , A61K31/40 , A61K31/675
CPC分类号： A61K38/07 , A61K31/4025 , A61K31/4184 , A61K31/427 , A61K31/473 , A61K31/513 , A61K31/7072 , A61K38/05 , A61K38/06 , A61K38/12 , A61K45/06 , G06F17/10 , G06F19/12
摘要： The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).
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公开(公告)号：US20130102558A1
公开(公告)日：2013-04-25
申请号：US13603006
申请日：2012-09-04
申请人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
发明人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC分类号： A61K31/7076 , A61K31/497 , A61K31/513 , A61P31/14 , A61K31/4709 , A61K31/427 , A61K31/4178 , A61K31/4025 , A61K31/7072 , A61K31/4725
CPC分类号： A61K38/07 , A61K31/4025 , A61K31/4184 , A61K31/427 , A61K31/473 , A61K31/513 , A61K31/7072 , A61K38/05 , A61K38/06 , A61K38/12 , A61K45/06 , G06F17/10 , G06F19/12
摘要： The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents without interferon and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to a subject an effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), and an inhibitor of cytochrome P450 (e.g., ritonavir).
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公开(公告)号：US20130102525A1
公开(公告)日：2013-04-25
申请号：US13603022
申请日：2012-09-04
申请人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
发明人： Barry M. Bernstein , Rajeev M. Menon , Amit Khatri , Sven Mensing , Sandeep Dutta , Daniel E. Cohen , Thomas J. Podsadecki , Scott C. Brun , Walid M. Awni , Emily O. Dumas , Cheri E. Klein
IPC分类号： A61K31/7056 , A61P31/14 , A61K38/07
CPC分类号： A61K38/07 , A61K31/402 , A61K31/4025 , A61K31/4184 , A61K31/426 , A61K31/427 , A61K31/4709 , A61K31/497 , A61K31/513 , A61K31/675 , A61K31/7056 , A61K31/7072 , A61K38/05 , A61K38/12 , A61K45/06 , A61K2300/00
摘要： The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies comprise administering at least two direct acting antiviral agents and ribavirin to a subject with HCV infection. For example, the therapies comprise administering to the subject effective amounts of therapeutic agent 1, therapeutic agent 2 (or therapeutic agent 3), an inhibitor of cytochrome P450 (e.g., ritonavir), and ribavirin.
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公开(公告)号：US09044480B1
公开(公告)日：2015-06-02
申请号：US13412167
申请日：2012-03-05
申请人： Tami Pilot-Matias , Isabelle A. Gaultier , Rakesh L. Tripathi , Christine A. Collins , Daniel E. Cohen , Barry M. Bernstein
发明人： Tami Pilot-Matias , Isabelle A. Gaultier , Rakesh L. Tripathi , Christine A. Collins , Daniel E. Cohen , Barry M. Bernstein
IPC分类号： A61K38/00 , A61K31/33 , A61K31/44 , A61K31/497
CPC分类号： A61K31/497 , A61K31/427 , A61K2300/00
摘要： The present invention features methods of using Compound I to suppress HCV mutants, treat treatment-experienced HCV patients, and treat HCV patients having non-CC IL28B rs12979860 genotype.
摘要翻译： 本发明的特征在于使用化合物I抑制HCV突变体，治疗经历的HCV患者以及治疗具有非CC IL28B rs12979860基因型的HCV患者的方法。
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公开(公告)号：US09949004B2
公开(公告)日：2018-04-17
申请号：US13936154
申请日：2013-07-06
申请人： Daniel E. Cohen
发明人： Daniel E. Cohen
CPC分类号： H04R1/025 , A61H23/0236 , A61H2201/0138 , A61H2201/0149 , A61H2201/10 , A61H2201/1654 , A61H2201/5005 , A61H2203/0425 , A61H2203/0443 , A61H2205/062 , A61H2205/086 , A61N2/002 , A61N2/008 , A61N2/06 , H04R1/028 , H04R5/023 , H04R5/04
摘要： An apparatus capable of transmitting sound and vibrations to a user is described. The apparatus may also generate an electromagnetic field sufficient to stimulate the user's energy system. The apparatus includes a support structure configured to support at least a part of the user's body; a transducer coupled to the frame of the support structure in a manner which allows the transducer to move in relation to the frame; and an audio signal source for transmitting audio signals to the transducer. The transducer is capable of receiving and responding to audio signals having a wide range of audio frequencies when the apparatus is in use.
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公开(公告)号：US07553288B2
公开(公告)日：2009-06-30
申请号：US10943186
申请日：2004-09-16
申请人： Daniel E. Cohen
发明人： Daniel E. Cohen
IPC分类号： A61H23/02
CPC分类号： H04R5/023 , A61H23/0236 , A61H2201/0138 , A61H2203/0425 , A61H2203/0443 , A61H2205/062 , H04R5/04
摘要： The present invention is directed to a pad and sound transmission system which is adapted to directly transmit audible sound waves into the body at high intensity levels. In one embodiment, the subject invention includes a back pad and a seat pad. Each pad includes a speaker module having an acoustic speaker disposed within the pad and surrounded by a plurality of different layers.
摘要翻译： 本发明涉及一种衬垫和声音传输系统，其适于以高强度水平将可听声波直接传输到身体中。 在一个实施例中，本发明包括背垫和座垫。 每个垫包括扬声器模块，该扬声器模块具有设置在该垫内并由多个不同层包围的声音扬声器。
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公开(公告)号：US06352548B1
公开(公告)日：2002-03-05
申请号：US09379425
申请日：1999-08-23
IPC分类号： A61M2900
摘要： Devices and methods for facilitating air flow in the nasal passages of domestic animals. The devices include support devices for supporting unsupported tissues of the nasal passages which facilitate air flow during rest, physical exertion, respiratory ailment, etc. Components and methods to facilitate application of the support device to the nose of an animal are also disclosed.
摘要翻译： 用于促进家畜鼻腔通气的装置和方法。 这些装置包括用于支撑鼻通道的无支撑组织的支撑装置，其有利于休息期间的空气流动，体力消耗，呼吸道疾病等。有利于将支撑装置应用于动物鼻子的组件和方法也被公开。
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公开(公告)号：US20220001191A1
公开(公告)日：2022-01-06
申请号：US17290748
申请日：2019-10-30
申请人： Daniel E. COHEN , Jennifer PALMQUIST , David COHEN , Bruce C. JOHNSON , Ellen COHEN , Dan Alan PRESTON , Round River Research Corporation
发明人： Daniel E. Cohen , Jennifer Palmquist , David Cohen , Bruce C. Johnson , Ellen Cohen , Dan Alan Preston
摘要： It is well understood in the medical industry that medical disorders can manifest as serious problems for the affected subjects, their families, and society. Today, psychiatrists, neurologists and other physicians treat these disorders with a variety of medications, many of which have significant negative side effects. The teachings provided herein are directed to a novel system and methods for treating certain neurological, psychological, psychiatric and medical disorders by delivering a “magnetic stimulation” to a subject's neural and perineural system using either a static or electromagnetic field to generate a modulated variable power multi-spectral magnetic stimulation on three axis; the modulated stimulation using methods that have predictable, controlled, modifiable, and repeatable characteristics.
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公开(公告)号：US08739804B2
公开(公告)日：2014-06-03
申请号：US13497742
申请日：2010-09-22
IPC分类号： A45D40/30 , A45D24/00 , A45D40/26 , A61F5/08 , B32B9/00 , B32B33/00 , B65D73/00 , A61F13/00 , A61F15/00 , G09F3/10 , A45D44/12 , A45D44/22
摘要： A mechanism for releasing an eye strip from a backing material card is described. The backing material card includes a movable flap that releases a right and/or left undamaged end of a strip (for right or left hand preference) into free space in order to conveniently lift the strip off the backing material, preferably between the user's thumb and index finger, for proper orientation and placement on the eyelid.
摘要翻译： 描述了用于从背衬材料卡释放眼条的机构。 背衬材料卡包括可移动的折板，其将条带的右侧和/或左侧未损坏的端部（用于右侧或左侧偏好）释放到自由空间中，以便方便地将该剥离物从背衬材料提起，优选地在使用者的拇指和 食指，用于正确定位和放置在眼睑上。
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