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公开(公告)号：US20210379142A1
公开(公告)日：2021-12-09
申请号：US17184256
申请日：2021-02-24
IPC分类号： A61K38/10 , A61K38/12 , A61K45/06 , A61K38/04 , A61K31/53 , A61K31/192 , A61K31/352 , A61K31/4468 , A61K31/501 , A61K31/519 , A61K31/7004 , A61K9/28 , A61K31/194 , A61K33/42
摘要： This invention provides a method of colonic cleansing.
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公开(公告)号：US20200316164A1
公开(公告)日：2020-10-08
申请号：US16853352
申请日：2020-04-20
摘要： This invention provides composition and methods to prevent, treat or alleviate a symptom of ulcerative colitis comprising administering to a patient dolcanatide.
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公开(公告)号：US20200330548A1
公开(公告)日：2020-10-22
申请号：US16874218
申请日：2020-05-14
IPC分类号： A61K38/10 , A61K31/53 , A61K31/451 , A61K38/51 , A61K31/192 , A61K31/135 , A61K31/222 , A61K31/519 , A61K31/485 , A61K38/04 , A61K31/4468 , A61K45/06
摘要： This invention provides a method to prevent, control, and/or treat opioid induced dysfunctions comprising administering to a patient in need a guanylate cyclase receptor agonist (GCRA) peptide. Compositions comprising guanylate cyclase receptor agonist (GCRA) peptides, methods of making, and methods of treatment are also disclosed.
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公开(公告)号：US20200009063A1
公开(公告)日：2020-01-09
申请号：US16018278
申请日：2018-06-26
IPC分类号： A61K9/48 , A61K31/53 , A61K38/04 , A61K45/06 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , C07K7/08 , C07K14/245 , C07K14/47 , A61K9/00 , A61K38/10
摘要： The invention provides novel formulations of guanylate cyclase-C (“GCC”) agonist peptides and methods for their use in the treatment of gastrointestinal diseases and disorders, including gastrointestinal cancer. The GCC agonist formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.
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公开(公告)号：US20200054709A1
公开(公告)日：2020-02-20
申请号：US16436401
申请日：2019-06-10
IPC分类号： A61K38/10 , A61K33/42 , A61K31/194 , A61K9/28 , A61K31/7004 , A61K31/519 , A61K31/501 , A61K31/4468 , A61K31/352 , A61K31/192 , A61K31/53 , A61K38/04 , A61K45/06 , A61K38/12
摘要： This invention provides a method of colonic cleansing.
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公开(公告)号：US20200023080A1
公开(公告)日：2020-01-23
申请号：US15777273
申请日：2016-11-18
摘要： The present invention provides methods of detecting and treating colon cancer using conjugates comprising a GCRA peptide and one or more components such as a drug delivery vehicle, a chemotherapeutic agent, a micelle, a nanoparticle, a liposome, a polymer, a lipid, an imaging agent, and a labeling agent.
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公开(公告)号：US20200009215A1
公开(公告)日：2020-01-09
申请号：US16577880
申请日：2019-09-20
摘要： This invention provides a method to prevent, control, and/or treat opioid induced dysfunctions comprising administering to a patient in need a guanylate cyclase receptor agonist (GCRA) peptide. Compositions comprising guanylate cyclase receptor agonist (GCRA) peptides, methods of making, and methods of treatment are also disclosed.
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