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公开(公告)号:US08710044B2
公开(公告)日:2014-04-29
申请号:US13703276
申请日:2011-07-01
申请人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号: A61K31/00 , A61K31/519 , C07D239/72
CPC分类号: C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型双环氮杂杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20130137677A1
公开(公告)日:2013-05-30
申请号:US13703276
申请日:2011-07-01
申请人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号: C07D239/94 , A61K45/06 , A61K31/517 , C07D403/12
CPC分类号: C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型双环氮杂杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08637532B2
公开(公告)日:2014-01-28
申请号:US13148903
申请日:2010-02-04
申请人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20140107156A1
公开(公告)日:2014-04-17
申请号:US14105974
申请日:2013-12-13
申请人: Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号: C07D215/04 , A61K31/47
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08735584B2
公开(公告)日:2014-05-27
申请号:US12919136
申请日:2009-02-25
申请人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号: C07D471/04 , C07D471/06
CPC分类号: C07D471/04
摘要: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译: 公开了苯并萘并吡啶基衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制,调节或调节的疾病。
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公开(公告)号:US20110053906A1
公开(公告)日:2011-03-03
申请号:US12919136
申请日:2009-02-25
申请人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
发明人: Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Christopher Charles Victor Jones , Srinivasa R. Karra , Yufang Xiao , Andreas Goutopoulos , Amanda E. Sutton
IPC分类号: A61K31/4745 , C07D471/04 , A61K31/5377 , A61K31/496 , A61K31/536 , A61P35/00
CPC分类号: C07D471/04
摘要: Disclosed are benzonaphthyridinyl derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to kinase signal transduction inhibition, regulation or modulation.
摘要翻译: 公开了苯并萘并吡啶基衍生物化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于激酶信号转导抑制,调节或调节的疾病。
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公开(公告)号:US08569295B2
公开(公告)日:2013-10-29
申请号:US13388952
申请日:2010-07-28
申请人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
发明人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
IPC分类号: C07D471/04 , C07D498/14 , A61K31/519
CPC分类号: C07D471/04 , C07D498/14
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20120190654A1
公开(公告)日:2012-07-26
申请号:US13388952
申请日:2010-07-28
申请人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
发明人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
IPC分类号: A61K31/519 , C07D498/14 , A61K31/5365 , C07D471/14 , A61K31/5377 , A61K31/635 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P13/08 , A61P9/00 , A61P17/06 , A61P17/04 , A61P17/00 , A61P3/10 , A61P27/02 , C07D519/00 , C07D471/04
CPC分类号: C07D471/04 , C07D498/14
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20120046269A1
公开(公告)日:2012-02-23
申请号:US13148903
申请日:2010-02-04
申请人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号: A61K31/517 , C07D401/12 , A61K31/4709 , C07D405/12 , C07D409/12 , C07D403/12 , C07D401/04 , C07D413/12 , A61K31/5377 , C07D413/04 , C07D401/14 , C07D417/12 , C07D413/14 , C07D409/10 , C07D471/04 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P17/00 , A61P9/00 , A61P17/06 , A61P3/10 , A61P27/02 , C07D239/94
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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10.C-Ring Modified Tricyclic Benzonaphthiridinone Protein Kinase Inhibitors and Use Thereof 审中-公开
标题翻译: C环改性三环苯并萘啶酮蛋白激酶抑制剂及其用途公开(公告)号:US20110312951A1
公开(公告)日:2011-12-22
申请号:US13140090
申请日:2009-12-02
IPC分类号: A61K31/538 , C07D471/14 , C07D491/147 , C07D495/14 , C07D471/04 , A61P37/00 , A61P35/00 , A61P9/10 , A61P3/10 , A61P27/02 , A61P29/00 , A61P19/02 , A61P25/28 , A61P17/06 , A61P17/02 , A61P3/00 , A61K31/4375
CPC分类号: C07D471/04 , C07D471/14 , C07D491/147 , C07D495/14
摘要: Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.
摘要翻译: 公开了C环改性的三环苯并萘环酮化合物及其类似物,包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于蛋白激酶信号转导抑制,调节和/或调节的疾病。
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