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公开(公告)号:US20120046269A1
公开(公告)日:2012-02-23
申请号:US13148903
申请日:2010-02-04
申请人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Steiber , Brian L. Hodous , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号: A61K31/517 , C07D401/12 , A61K31/4709 , C07D405/12 , C07D409/12 , C07D403/12 , C07D401/04 , C07D413/12 , A61K31/5377 , C07D413/04 , C07D401/14 , C07D417/12 , C07D413/14 , C07D409/10 , C07D471/04 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P17/00 , A61P9/00 , A61P17/06 , A61P3/10 , A61P27/02 , C07D239/94
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20140107156A1
公开(公告)日:2014-04-17
申请号:US14105974
申请日:2013-12-13
申请人: Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Thomas E. Richardson , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Andreas Goutopoulos , Ruoxi Lan , David Perrey , Harold George Vandeveer , Lesley Liu-Bujalski , Frank Steiber , Hui Qiu , Reinaldo C. Jones , Brian H. Heasley
IPC分类号: C07D215/04 , A61K31/47
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08637532B2
公开(公告)日:2014-01-28
申请号:US13148903
申请日:2010-02-04
申请人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
发明人: Amanda E. Sutton , Ruoxi Lan , Thomas E. Richardson , David Perrey , Harold George Vandeveer , Bayard R. Huck , Srinivasa R. Karra , Xiaoling Chen , Yufang Xiao , Lesley Liu-Bujalski , Andreas Goutopoulos , Frank Stieber , Brian L. Hodous , Hui Qiu , Reinaldo Jones , Brian H. Heasley
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号: C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氨基氮杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08569295B2
公开(公告)日:2013-10-29
申请号:US13388952
申请日:2010-07-28
申请人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
发明人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
IPC分类号: C07D471/04 , C07D498/14 , A61K31/519
CPC分类号: C07D471/04 , C07D498/14
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20120190654A1
公开(公告)日:2012-07-26
申请号:US13388952
申请日:2010-07-28
申请人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
发明人: Xiaoling Chen , Srinivasa R. Karra , Bayard R. Huck , Ruoxi Lan , Amanda E. Sutton , Andreas Goutopoulos , Brian L. Hodous , Reinaldo Jones
IPC分类号: A61K31/519 , C07D498/14 , A61K31/5365 , C07D471/14 , A61K31/5377 , A61K31/635 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P13/08 , A61P9/00 , A61P17/06 , A61P17/04 , A61P17/00 , A61P3/10 , A61P27/02 , C07D519/00 , C07D471/04
CPC分类号: C07D471/04 , C07D498/14
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US08710044B2
公开(公告)日:2014-04-29
申请号:US13703276
申请日:2011-07-01
申请人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号: A61K31/00 , A61K31/519 , C07D239/72
CPC分类号: C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型双环氮杂杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20130137677A1
公开(公告)日:2013-05-30
申请号:US13703276
申请日:2011-07-01
申请人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
发明人: Bayard R. Huck , Constantin Neagu , Reinaldo Jones , Lizbeth Celeste DeSelm , Yufang Xiao , Srinivasa R. Karra , Ruoxi Lan , Igor Mochalkin , Amanda E. Sutton , Thomas E. Richardson
IPC分类号: C07D239/94 , A61K45/06 , A61K31/517 , C07D403/12
CPC分类号: C07D239/94 , A61K31/517 , A61K45/06 , C07D239/74 , C07D403/12
摘要: The invention provides novel bicyclic azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型双环氮杂杂环甲酰胺化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US09023847B2
公开(公告)日:2015-05-05
申请号:US13388690
申请日:2010-07-22
申请人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
发明人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
IPC分类号: C07D471/04 , C07D333/02 , C07D487/04
CPC分类号: C07D471/04 , C07D333/02 , C07D487/04
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20120277228A1
公开(公告)日:2012-11-01
申请号:US13388690
申请日:2010-07-22
申请人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
发明人: Amanda E. Sutton , Nadia Brugger , Thomas E. Richardson , Harold George Vandeveer , Bayard R. Huck , Ruoxi Lan , Justin Potnick
IPC分类号: C07D471/04 , A61K31/5377 , A61K31/496 , C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P1/18 , A61P13/12 , A61P25/00 , A61P17/00 , A61P13/08 , A61P17/06 , A61P3/10 , A61P27/02 , A61K31/437
CPC分类号: C07D471/04 , C07D333/02 , C07D487/04
摘要: The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)的新型取代的氮杂环化合物,其用于治疗过度增殖性疾病如癌症的制备和用途。
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公开(公告)号:US20140343029A1
公开(公告)日:2014-11-20
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/506 , C07D413/14 , C07D491/107 , C07D409/14 , C07D417/14 , A61K31/5377 , A61K31/4545
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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