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公开(公告)号：US20230064576A1
公开(公告)日：2023-03-02
申请号：US17309764
申请日：2019-12-19
发明人： Victor CHEN , Pierre SRISTAU , Mazen ES-SAYED , Julie GEIST , Mathieu GOURGUES , Dominique LOQUE , Anthony MILLET , Anne-Sophie REBSTOCK , Alexander SUDAU , Vincent Pierre Andre THOMAS , Valére TOQUIN , Tomoki TSUCHIYA
IPC分类号： A01N43/88 , C07D413/04 , C07D403/04 , C07D417/04 , A01N43/707 , A01N43/58 , A01P3/00
摘要： The present disclosure relates to heterocyclyl pyridazine compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
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公开(公告)号：US20210009541A1
公开(公告)日：2021-01-14
申请号：US16968804
申请日：2019-02-11
发明人： Stephane BRUNET , Philippe DESBORDES , Sophie DUCERF , Jeremy DUFOUR , Andreas GOERTZ , Mathieu GOURGUES , Emmanuelle HILT , Sebastien NAUD , Anne-Sophie REBSTOCK , Vincent THOMAS , Aurelia VERNAY , Francois VILLALBA
IPC分类号： C07D271/06 , A01N43/82 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention relates to oxadiazole derivatives thereof that may be used as fungicides.
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公开(公告)号：US20230338559A1
公开(公告)日：2023-10-26
申请号：US18182093
申请日：2023-03-10
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Beatrix STELTE-LUDWIG , Dennis KIRCHHOFF , Lisa DIETZ , Christoph MAHLERT , Simone GREVEN , Stephan MÄRSCH , Sandra BERNDT , Anette SOMMER , Stefanie HAMMER
CPC分类号： A61K47/6803 , A61K47/65 , A61K47/6849 , A61K47/6855 , A61P35/00 , C07K16/2827 , C07K16/2863 , C07K16/2866 , C07K16/2878 , C07K16/32 , A61K2039/505
摘要： The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
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公开(公告)号：US20230054449A1
公开(公告)日：2023-02-23
申请号：US17297984
申请日：2019-11-27
发明人： Victor CHEN , Pierre CRISTAU , Jérémy DUFOUR , Mazen ES-SAYED , Julie GEIST , Mathieu GOURGUES , Dominique LOQUE , Anthony MILLET , Daniel RACKL , Anne-Sophie REBSTOCK , Philippe RINOLFI , Yoshitaka SATO , Alexander SUDAU , Vincent THOMAS , Valérie TOQUIN
IPC分类号： A01N43/58 , C07D237/24 , C07D471/04 , A01N43/90 , C07D401/04 , C07D405/12 , C07D401/12 , A01P3/00
摘要： The present disclosure relates to pyridazine (thio)amide compounds, processes and intermediates for their preparation as well as the uses thereof for controlling phytopathogenic microorganisms, such as phytopathogenic fungi.
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公开(公告)号：US20210007359A1
公开(公告)日：2021-01-14
申请号：US16955390
申请日：2018-12-21
发明人： Anne-Sophie REBSTOCK , Sebastien NAUD , Stephane BRUNET , Mathieu GOURGUES , Harald JAKOBI , Andreas GOERTZ , Emmanuelle HILT , Sophie DUCERF
IPC分类号： A01N43/82 , C07D413/14 , C07D413/04 , C07D413/10
摘要： The present invention relates to heterocyclylaminophenyloxadiazole and derivatives thereof that may be used and as fungicides.
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公开(公告)号：US20190351066A1
公开(公告)日：2019-11-21
申请号：US16472634
申请日：2017-12-18
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Leo MARX , Sarah Anna Liesa JOHANNES , Beatrix STELTE-LUDWIG , Lisa DIETZ , Hannah JOERISSEN , Christoph MAHLERT , Simone GREVEN , Anette SOMMER
IPC分类号： A61K47/68 , C07D207/335 , A61K31/402 , A61K47/65 , A61P35/00
摘要： The invention relates to novel prodrugs or conjugates of the general formula (Ia) in which La, n, R and D have the definitions given in the description and which have a structural motif reduced to an asparagine derivative as cleavage site for tumour-associated proteases such as legumain, in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are released by legumain cleavage, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers. Reduction of the legumain-cleavable substrate peptide sequence to an asparagine derivative as structural motif, as a result of slowed legumain cleavage, achieves an increase in stability in the lysosomes of healthy organs while simultaneously maintaining the high anti-tumour effect.
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公开(公告)号：US20190241562A1
公开(公告)日：2019-08-08
申请号：US16317322
申请日：2017-07-04
发明人： Henrik TELLER , Melissa BOULTADAKIS ARAPINIS , Alexandros VAKALOPOULOS , Anne-Sophie REBSTOCK , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Klaus MÜNTER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/04 , A61P13/12 , A61P9/06
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20220144815A1
公开(公告)日：2022-05-12
申请号：US17415496
申请日：2019-12-20
发明人： Stephane BRUNET , Pierre-Yves COQUERON , Philippe DESBORDES , Sophie DUCERF , Jeremy DUFOUR , Andreas GOERTZ , Emmanuelle HILT , Aurelie MALLINGER , Sebastien NAUD , Anne-Sophie REBSTOCK , Vincent THOMAS
IPC分类号： C07D413/04 , C07D413/14 , A01N43/82 , A01P3/00
摘要： The present disclosure relates to the use of 1,3,4-oxadiazoles and derivatives thereof as fungicide. It also relates to new 1,3,4-oxadiazoles derivatives, their use as fungicide and compositions comprising thereof.
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公开(公告)号：US20210009575A1
公开(公告)日：2021-01-14
申请号：US16955576
申请日：2019-12-21
发明人： Anne-Sophie REBSTOCK , Sebastien NAUD , Stephane BRUNET , Mathieu GOURGUES , Francois Michel VILLALBA , Aurelia VERNAY , Birgit KUHN , Andreas GOERTZ , Philippe DESBORDES , Jeremy DUFOUR , Emmanuelle HILT , Sophie DUCERF
IPC分类号： C07D413/14 , A01N43/80 , C07D413/06 , C07D419/04 , C07D419/14
摘要： The present disclosure relates to the use of hydroxyisoxazolines and derivatives thereof as fungicide. It also relates to new hydroxyisoxazolines derivatives, their use as fungicide and compositions comprising thereof.
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公开(公告)号：US20190328897A1
公开(公告)日：2019-10-31
申请号：US16472749
申请日：2017-12-14
发明人： Hans-Georg LERCHEN , Anne-Sophie REBSTOCK , Beatrix STELTE-LUDWIG , Dennis KIRCHHOFF , Lisa DIETZ , Christoph MAHLERT , Simone GREVEN , Stephan MÄRSCH , Sandra BERNDT , Anette SOMMER , Stefanie HAMMER
摘要： The invention relates to novel binder-drug conjugates (ADCs) having improved properties, to active metabolites of these ADCs and to processes for their preparation. The present invention furthermore relates to the use of these conjugates for the treatment and/or prevention of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases.
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