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公开(公告)号：US20230064809A1
公开(公告)日：2023-03-02
申请号：US17780814
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , Dennis KIRCHHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Rienk OFFRINGA
IPC分类号： A61K31/4709 , C07D471/10 , C07D487/10 , A61K31/5377 , A61K31/496 , A61P37/04 , A61P35/00 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, m, n, o and p are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230201186A1
公开(公告)日：2023-06-29
申请号：US18072490
申请日：2022-11-30
发明人： Norbert SCHMEES , Lars WORTMANN , Dennis KIRCHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , Dirk KOSEMUND , Rienk OFFRINGA , Mareike GREES
IPC分类号： A61K31/4545 , C07D401/14 , A61K31/498 , C07D413/14 , A61P37/04 , A61K31/55 , C07D401/04 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/4725 , A61P35/00 , A61K31/4709 , A61K45/06
CPC分类号： A61K31/4545 , C07D401/14 , A61K31/498 , C07D413/14 , A61P37/04 , A61K31/55 , C07D401/04 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/4725 , A61P35/00 , A61K31/4709 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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![[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES](/abs-image/US/2023/04/13/US20230113037A1/abs.jpg.150x150.jpg)
公开(公告)号：US20230113037A1
公开(公告)日：2023-04-13
申请号：US17634930
申请日：2020-08-10
发明人： Julien LEFRANC , Norbert SCHMEES , Ludwig ZORN , Robin Michael MEIER , Simon Anthony HERBERT , Judith GÜNTHER , Ilona GUTCHER , Lars RÖSE , Benjamin BADER , Detlef STÖCKIGT , Mátyás GORJÁNÁCZ , Christina KOBER , Bernd BUCHMANN , Stephan BÖHME , Ulrich BOTHE , Michael PLATTEN , Daniel BAUMANN
IPC分类号： C07D487/04
摘要： The present invention covers [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds of general formula (I) in which R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200283402A1
公开(公告)日：2020-09-10
申请号：US16765806
申请日：2018-11-16
发明人： Ilona GUTCHER , Ulrike RÖHN , Ludwig ZORN , Lars RÖSE , Benjamin BADER , Christina KOBER , Rafael CARRETERO , Detlef STÖCKIGT , Michael PLATTEN
IPC分类号： C07D401/04 , C07D403/04 , C07D409/14 , C07D405/14 , A61P35/04
摘要： The present invention covers 3-oxo-6-heteromyl-2-phenyl-2,3-dihydropyri-dazine-4-carboxamide compounds of general formula (I): in which R1, R2, R4, R5, R6, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200299269A1
公开(公告)日：2020-09-24
申请号：US16765709
申请日：2018-11-16
发明人： Ludwig ZORN , Ulrike RÖHN , Ilona GUTCHER , Lars RÖSE , Benjamin BADER , Christina KOBER , Rafael CARRETERO , Detlef STÖCKIGT , Michael PLATTEN
IPC分类号： C07D403/04 , C07D237/14 , C07D417/14 , C07D409/12 , C07D409/14 , A61P35/00
摘要： The present invention covers sulphur substituted 3-oxo-2,3-dihydropyridazine-4 carboxamide compounds of general formula (I): (I) in which R1, R2, A, X, Y and Z are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200283395A1
公开(公告)日：2020-09-10
申请号：US16765780
申请日：2018-11-16
发明人： Julien LEFRANC , Norbert SCHMEES , Ulrike RÖHN , Ludwig ZORN , Judith GÜNTHER , Ilona GUTCHER , Lars RÖSE , Benjamin BADER , Detlef STÖCKIGT , Michael PLATTEN
IPC分类号： C07D239/28 , C07D405/12 , A61P35/04
摘要： The present invention covers 2-phenylpyrimidine-4-carboxamide compounds of general formula (I): (I) 5 in which X, Y, Z, R1, R2, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230148194A1
公开(公告)日：2023-05-11
申请号：US17780890
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , DENNIS KIRCHHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , DIRK KOSEMUND , Rienk OFFRINGA , Mareike GREES
IPC分类号： A61K31/4545 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/4709 , A61K31/496 , A61K31/4725 , A61K31/498 , A61K31/55 , A61K45/06 , A61P35/00 , A61P37/04
CPC分类号： A61K31/4545 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/4709 , A61K31/496 , A61K31/4725 , A61K31/498 , A61K31/55 , A61K45/06 , A61P35/00 , A61P37/04
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230062100A1
公开(公告)日：2023-03-02
申请号：US17780903
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , DENNIS KIRCHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , DIRK KOSEMUND , Julien LEFRANC , Rienk OFFRINGA
IPC分类号： A61K31/4709 , C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14 , C07F9/6558 , C07D417/14 , A61K31/513 , A61K31/496 , A61K31/506 , A61K31/675 , A61K31/55 , A61P37/04 , A61P35/00 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200289509A1
公开(公告)日：2020-09-17
申请号：US16765778
申请日：2017-11-16
发明人： Julien LEFRANC , Norbert SCHMEES , Ulrike RÖHN , Ludwig ZORN , Judith GÜNTHER , Ilona GUTCHER , Lars RÖSE , Benjamin BADER , Detlef STÖCKIGT , Michael PLATTEN
IPC分类号： A61K31/506 , C07D403/04 , C07D401/04 , C07D409/04 , C07D413/04 , C07D401/14 , C07D409/14 , C07D405/14
摘要： The present invention covers 2-hetarylpyrimidine-4-carboxamide compounds of general formula (I): in which X, Y, Z, R1, R2 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20240294505A1
公开(公告)日：2024-09-05
申请号：US16485049
申请日：2018-02-02
发明人： Ilona GUTCHER , Ulrike RÖHN , Norbert SCHMEES , Ludwig ZORN , Lars RÖSE , Benjamin BADER , Christina KOBER , Rafael CARRETERO , Detlef STÖCKIGT , Horst IRLBACHER , Michael PLATTEN
IPC分类号： C07D403/04 , A61K31/501 , A61K31/506 , A61K45/06 , A61P35/00 , C07D237/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
CPC分类号： C07D403/04 , A61K31/501 , A61K31/506 , A61K45/06 , A61P35/00 , C07D237/14 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention covers 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I), in which X, R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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