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1.发明授权Method for producing 4-haloalkyl-3-mercapto-substituted 2-hydroxy-benzoic acid derivatives 有权制备4-卤代烷基-3-巯基取代的2-羟基 - 苯甲酸衍生物的方法公开(公告)号：US09440917B2
公开(公告)日：2016-09-13
申请号：US14650905
申请日：2013-12-10
Applicant: BAYER CROPSCIENCE AG
Inventor： Mark James Ford , Gunter Karig
IPC: C07C321/00 , C07C319/20 , C07C323/54
CPC classification number: C07C319/20 , C07C323/54 , C07C323/62
Abstract: A process is described for preparing 4-haloalkyl-3-mercapto-substituted 2-hydroxybenzoic acid derivatives of the general formula (I) by reaction of 4-thio-substituted β-keto esters of the formula (II) with alkoxyvinyl haloalkyl ketones of the formula (III) in the presence of a base. In the above formulae, X, R1, R2 and R3 are each hydrogen, halogen, alkyl, alkoxy and cycloalkyl.
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2.发明申请PROCESS FOR THE PREPARATION OF OXINDOLES AND ORTHO-SUBSTITUTED ANILINES AND THEIR USE AS INTERMEDIATES FOR SYNTHESES 有权制备氧化物和取代的苯胺的方法及其作为合成中间体的使用公开(公告)号：US20130281711A1
公开(公告)日：2013-10-24
申请号：US13915898
申请日：2013-06-12
Applicant: Bayer CropScience AG
Inventor： Mark James Ford , Gunter Karig
IPC: C07D209/34
CPC classification number: C07D209/34 , C07C323/58
Abstract: The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above −65° C.In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8):
Abstract translation: 本发明涉及制备羟吲哚和邻位取代苯胺的方法及其作为合成中间体的用途。 本发明还涉及制备式（4）化合物的方法：其中苯胺（式Q化合物）的混合物与硫醚（式W化合物）反应：在氯化剂和 在随后的方法中，该化合物在酸催化剂的存在下进一步反应，得到式（7）的吲哚或式（8）的羟吲哚， ：
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3.发明授权Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses 有权制备羟吲哚和邻位取代苯胺的方法及其作为合成中间体的用途公开(公告)号：US09242934B2
公开(公告)日：2016-01-26
申请号：US13915898
申请日：2013-06-12
Applicant: Bayer CropScience AG
Inventor： Mark James Ford , Gunter Karig
IPC: C07D209/34 , C07C323/58
CPC classification number: C07D209/34 , C07C323/58
Abstract: The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above −65° C. In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8):
Abstract translation: 本发明涉及制备羟吲哚和邻位取代苯胺的方法及其作为合成中间体的用途。 本发明还涉及制备式（4）化合物的方法：其中苯胺（式Q化合物）的混合物与硫醚（式W化合物）反应：在氯化剂和 在随后的方法中，该化合物在酸催化剂的存在下进一步反应，得到式（7）的吲哚或式（8）的羟吲哚， ：
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