公开(公告)号：US20210261536A1

公开(公告)日：2021-08-26

申请号：US16306180

申请日：2017-05-26

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Stefan ANTONS ,  Martin LITTMANN ,  Joerg SCHULZ ,  Wahed Ahmed MORADI ,  Thomas GELLER

IPC: C07D417/06

Abstract: The present invention relates to a process for producing compounds of formula (I) in which R1, A, X and Z are as defined in the description by reaction of compounds of formula (II) or salts thereof with 2-chloro-5-chloromethylpyridine in a nonpolar aliphatic or aromatic solvent, preferably in the presence of a phase transfer catalyst.

公开(公告)号：US20200039936A1

公开(公告)日：2020-02-06

申请号：US16471144

申请日：2017-12-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Thomas HIMMLER ,  Thomas Norbert MUELLER

IPC: C07D213/26 ,  C07D213/40

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluoromethyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of Raney catalysts, in particular Raney nickel or cobalt.

公开(公告)号：US20170081284A1

公开(公告)日：2017-03-23

申请号：US15126593

申请日：2015-03-18

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Guenter SCHLEGEL ,  Albert SCHNATTERER

IPC: C07D213/38

CPC classification number: C07D213/38 ,  C07D213/61

Abstract: A process for preparing N-[(6-chloropyridin-3-yl)methyl]-2,2-difluoroethan-1-amine of formula (III) wherein 2,2-difluoroethylamine of formula (I) is reacted with a halide of formula (II) in the presence of a hydroxide of an alkali metal or alkaline earth metal.

公开(公告)号：US20200039937A1

公开(公告)日：2020-02-06

申请号：US16471132

申请日：2017-12-12

Applicant: Bayer CropScience Aktiengesellschaft

Inventor： Wahed Ahmed MORADI ,  Albert SCHNATTERER ,  Dietmar BIELEFELDT ,  Rolf GERTZMANN ,  Dirk HAVEKOST

IPC: C07D213/61

Abstract: Described is a process for the preparation of a N-[2-(2-pyridinyl)ethyl]carboxamide derivative of general formula (I) or a salt thereof

公开(公告)号：US20180297952A1

公开(公告)日：2018-10-18

申请号：US15569528

申请日：2016-04-26

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Günter SCHLEGEL ,  Albert SCHNATTERER ,  Frank VOLZ

IPC: C07D213/61 ,  C07D213/40

Abstract: The present invention relates to novel processes for the preparation of substituted pyridyl-methylbenzamide derivatives of formula (I), in particular 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)-2-pyridyl]methyl}benzamide (Fluopicolide), and for the catalytic hydrogenation of substituted cyanopyridine derivatives, in particular 3-chloro-2-cyano-5-trifluoromethylpyridine [=Py-CN] to the corresponding substituted 2-methylaminopyridine derivatives, in particular 2-aminomethyl-3-chloro-5-trifluoromethylpyridine [=Py-methylamine] or salts thereof in the presence of metal catalysts such as in particular palladium catalysts, catalytic modifiers and acids.

公开(公告)号：US20160280648A1

公开(公告)日：2016-09-29

申请号：US15033987

申请日：2014-11-11

Applicant: BAYER CROPSCIENCE AKTIENGESELLSCHAFT

Inventor： Wahed Ahmed MORADI ,  Thomas HIMMLER ,  Thomas Norbert MUELLER ,  Albert SCHNATTERER ,  Guenter SCHLEGEL

IPC: C07D213/56

CPC classification number: C07D213/56 ,  C07D213/38 ,  C07D213/57 ,  C07D213/89

Abstract: The present invention relates to a novel catalytic hydrogenation of substituted 2-methyl cyanopyridyl derivatives, in particular 3-chloro-5-(trifluorometyl)pyridin-2-yl]acetonitrile [=Py-CN] to substituted 2-ethylaminopyridine derivatives, in particular 2-[3-chloro-5-(trifluorometyl)pyridin-2-yl]ethanamine [=Py-ethanamine] or salts thereof in the presence of metal catalysts, in particular palladium catalysts.

Abstract translation: 本发明涉及取代的2-甲基氰基吡啶衍生物，特别是3-氯-5-（三氟甲基）吡啶-2-基]乙腈[= Py-CN]到取代的2-乙基氨基吡啶衍生物的催化氢化，特别是 2- [3-氯-5-（三氟甲基）吡啶-2-基]乙胺[= Py-乙胺]或其盐在金属催化剂，特别是钯催化剂存在下。