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公开(公告)号：US09643953B2
公开(公告)日：2017-05-09
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09422268B2
公开(公告)日：2016-08-23
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09265763B2
公开(公告)日：2016-02-23
申请号：US14350160
申请日：2012-10-04
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/5377 , A61K31/5383 , A61K45/06
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US20140315934A1
公开(公告)日：2014-10-23
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernandez-Montalvan , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuße
IPC分类号： C07D401/14 , C07D405/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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公开(公告)号：US10266548B2
公开(公告)日：2019-04-23
申请号：US15438254
申请日：2017-02-21
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要： Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US10604532B2
公开(公告)日：2020-03-31
申请号：US16360811
申请日：2019-03-21
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A01H6/36 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要： Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09260412B2
公开(公告)日：2016-02-16
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09604989B2
公开(公告)日：2017-03-28
申请号：US14792205
申请日：2015-07-06
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The present invention relates to a method for the treatment of a cancer that is sensitive to Pi3K/Akt pathway inhibition by administering a therapeutically effective amount of a compound of formula (I)
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9.发明申请SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开用作BUB1激酶抑制剂治疗高增殖性疾病的替代苄基胆碱公开(公告)号：US20140249133A1
公开(公告)日：2014-09-04
申请号：US14350160
申请日：2012-10-04
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D498/04 , A61K31/506 , A61K31/5383 , C07D405/14 , A61K31/5377 , C07D413/14 , C07D401/14 , A61K45/06
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US09670202B2
公开(公告)日：2017-06-06
申请号：US14896426
申请日：2014-06-03
发明人： Hartmut Schirok , Volker Schulze , Dirk Kosemund , Hans Briem , Benjamin Bader , Ulf Bömer , Antje Margret Wengner , Gerhard Siemeister , Philip Lienau
IPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/496 , A61K31/5377 , A61K45/06
摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I); in which R1, R2, R3, R4, and R5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.
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