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公开(公告)号：US10266548B2
公开(公告)日：2019-04-23
申请号：US15438254
申请日：2017-02-21
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要： Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09643953B2
公开(公告)日：2017-05-09
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US10604532B2
公开(公告)日：2020-03-31
申请号：US16360811
申请日：2019-03-21
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A01H6/36 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要： Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09260412B2
公开(公告)日：2016-02-16
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09422268B2
公开(公告)日：2016-08-23
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09265763B2
公开(公告)日：2016-02-23
申请号：US14350160
申请日：2012-10-04
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/5377 , A61K31/5383 , A61K45/06
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US20140315934A1
公开(公告)日：2014-10-23
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernandez-Montalvan , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuße
IPC分类号： C07D401/14 , C07D405/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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8.发明申请SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开用作BUB1激酶抑制剂治疗高增殖性疾病的替代苄基胆碱公开(公告)号：US20140249133A1
公开(公告)日：2014-09-04
申请号：US14350160
申请日：2012-10-04
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D498/04 , A61K31/506 , A61K31/5383 , C07D405/14 , A61K31/5377 , C07D413/14 , C07D401/14 , A61K45/06
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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公开(公告)号：US09416125B2
公开(公告)日：2016-08-16
申请号：US14400315
申请日：2013-05-08
发明人： Marion Hitchcock , Christoph-Stephan Hilger , Anne Mengel , Hans Briem , Simon Holton , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Cornelia Preuβe , Mark Jean Gnoth
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07F7/18
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
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10.发明申请SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开作为治疗癌症的BUB1抑制剂的替代环孢噻嗪公开(公告)号：US20150141372A1
公开(公告)日：2015-05-21
申请号：US14400315
申请日：2013-05-08
发明人： Marion Hitchcock , Christoph-Stephan Hilger , Anne Mengel , Hans Briem , Simon Holton , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Cornelia Preuße , Mark Jean Gnoth
IPC分类号： C07D401/14 , A61K31/506 , A61K31/695 , A61K31/5377 , C07D405/14 , C07F7/18 , C07D403/04 , A61K45/06
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D405/14 , C07F7/1804 , C07F7/188
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
摘要翻译： 式（I）化合物，其生产方法及其作为Bub1激酶抑制剂用于治疗对细胞死亡诱导反应的过度增殖性疾病和/或病症的用途。
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