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公开(公告)号：US10266548B2
公开(公告)日：2019-04-23
申请号：US15438254
申请日：2017-02-21
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要： Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09422268B2
公开(公告)日：2016-08-23
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09265763B2
公开(公告)日：2016-02-23
申请号：US14350160
申请日：2012-10-04
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14 , C07D413/14 , C07D498/04 , A61K31/5377 , A61K31/5383 , A61K45/06
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US20140315934A1
公开(公告)日：2014-10-23
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernandez-Montalvan , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuße
IPC分类号： C07D401/14 , C07D405/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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公开(公告)号：US10604532B2
公开(公告)日：2020-03-31
申请号：US16360811
申请日：2019-03-21
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D401/14 , C07D498/04 , C07D405/14 , C07D413/14 , A01H6/36 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D403/04
摘要： Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.
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公开(公告)号：US09260412B2
公开(公告)日：2016-02-16
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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公开(公告)号：US09643953B2
公开(公告)日：2017-05-09
申请号：US14365895
申请日：2012-12-17
发明人： Marion Hitchcock , Anne Mengel , Anja Richter , Hans Briem , Knut Eis , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Simon Holton , Mark Jean Gnoth , Cornelia Preuβe
IPC分类号： C07D401/14 , A61K31/506 , C07D405/14
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
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8.发明申请SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES 审中-公开用作BUB1激酶抑制剂治疗高增殖性疾病的替代苄基胆碱公开(公告)号：US20140249133A1
公开(公告)日：2014-09-04
申请号：US14350160
申请日：2012-10-04
发明人： Marion Hitchcock , Anne Mengel , Vera Pütter , Gerhard Siemeister , Antje Margret Wengner , Hans Briem , Knut Eis , Volker Schulze , Amaury Ernesto Fernandez-Montalvan , Stefan Prechtl , Simon Holton , Jörg Fanghänel , Philip Lienau , Cornelia Preusse , Mark Jean Gnoth
IPC分类号： C07D498/04 , A61K31/506 , A61K31/5383 , C07D405/14 , A61K31/5377 , C07D413/14 , C07D401/14 , A61K45/06
CPC分类号： C07D498/04 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D413/14
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其制备方法及其作为药物的用途。
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9.发明申请SUBSTITUTED CYCLOALKENOPYRAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开作为治疗癌症的BUB1抑制剂的替代环孢噻嗪公开(公告)号：US20150141372A1
公开(公告)日：2015-05-21
申请号：US14400315
申请日：2013-05-08
发明人： Marion Hitchcock , Christoph-Stephan Hilger , Anne Mengel , Hans Briem , Simon Holton , Vera Pütter , Gerhard Siemeister , Stefan Prechtl , Amaury Ernesto Fernández-Montalván , Christian Stegmann , Cornelia Preuße , Mark Jean Gnoth
IPC分类号： C07D401/14 , A61K31/506 , A61K31/695 , A61K31/5377 , C07D405/14 , C07F7/18 , C07D403/04 , A61K45/06
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D405/14 , C07F7/1804 , C07F7/188
摘要： Compounds of formula (I), processes for their production and their use as Bub1 kinase inhibitors for the treatment of hyperproliferative diseases and/or disorders responsive to induction of cell death.
摘要翻译： 式（I）化合物，其生产方法及其作为Bub1激酶抑制剂用于治疗对细胞死亡诱导反应的过度增殖性疾病和/或病症的用途。
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公开(公告)号：US09682995B2
公开(公告)日：2017-06-20
申请号：US14764853
申请日：2014-01-28
发明人： Lars Bärfacker , Stefan Prechtl , Gerhard Siemeister , Antje Margret Wengner , Jens Ackerstaff , Katrin Nowak-Reppel , Benjamin Bader , Philip Lienau , Detlef Stöckigt , Tobias Heinrich
IPC分类号： C07D417/12 , C07D417/14 , C07D495/04 , C07D487/04 , C07D513/04
CPC分类号： C07D495/04 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention relates to isothiazoles of general formula (I) which inhibit the mitotic checkpoint: in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
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