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公开(公告)号：US20140287984A1
公开(公告)日：2014-09-25
申请号：US14355568
申请日：2012-10-30
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , July Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
摘要翻译： 本发明涉及基于新型聚乙二醇（PEG）的肾上腺髓质素前药，其制备方法及其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管，水肿和/或炎症性疾病。
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公开(公告)号：US10035818B2
公开(公告)日：2018-07-31
申请号：US15472476
申请日：2017-03-29
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US09315543B2
公开(公告)日：2016-04-19
申请号：US14355836
申请日：2012-10-29
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Ursula Krenz
CPC分类号： C07K5/0815 , A61K38/05 , A61K38/06 , A61K47/50 , A61K47/65 , C07K5/0215 , C07K5/06086
摘要： The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
摘要翻译： 本发明涉及新的基于酪氨酸的接头，其允许肽或蛋白质与其他分子实体的可释放连接，例如。 聚乙二醇，其制备方法及其用于制备用于治疗和/或预防疾病的药物的用途。
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公开(公告)号：US09649363B2
公开(公告)日：2017-05-16
申请号：US14986488
申请日：2015-12-31
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US09603936B2
公开(公告)日：2017-03-28
申请号：US14355568
申请日：2012-10-30
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
IPC分类号： A61K38/22 , A61K47/48 , C07K14/575
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US20160367636A1
公开(公告)日：2016-12-22
申请号：US14986488
申请日：2015-12-31
发明人： Ingo Flamme , Johannes Kobberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Kollnberger , Frank Wunder , Gordon Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
摘要翻译： 本发明涉及基于新型聚乙二醇（PEG）的肾上腺髓质素前药，其制备方法及其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管，水肿和/或炎症性疾病。
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