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公开(公告)号：US09315543B2
公开(公告)日：2016-04-19
申请号：US14355836
申请日：2012-10-29
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Ursula Krenz
CPC分类号： C07K5/0815 , A61K38/05 , A61K38/06 , A61K47/50 , A61K47/65 , C07K5/0215 , C07K5/06086
摘要： The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
摘要翻译： 本发明涉及新的基于酪氨酸的接头，其允许肽或蛋白质与其他分子实体的可释放连接，例如。 聚乙二醇，其制备方法及其用于制备用于治疗和/或预防疾病的药物的用途。
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公开(公告)号：US10035818B2
公开(公告)日：2018-07-31
申请号：US15472476
申请日：2017-03-29
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US20150051160A1
公开(公告)日：2015-02-19
申请号：US14355836
申请日：2012-10-29
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Lop , Sven Wittrock , Ursula Krenz
CPC分类号： C07K5/0815 , A61K38/05 , A61K38/06 , A61K47/50 , A61K47/65 , C07K5/0215 , C07K5/06086
摘要： The invention relates to novel tyrosine based linkers that allow the releasable connection of peptides or proteins with other molecular entities, e.g. polyethylene glycol, to processes for their preparation and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
摘要翻译： 本发明涉及新的基于酪氨酸的接头，其允许肽或蛋白质与其他分子实体的可释放连接，例如。 聚乙二醇，其制备方法及其用于制备用于治疗和/或预防疾病的药物的用途。
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公开(公告)号：US09649363B2
公开(公告)日：2017-05-16
申请号：US14986488
申请日：2015-12-31
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US09603936B2
公开(公告)日：2017-03-28
申请号：US14355568
申请日：2012-10-30
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , Julie Marley , Iain Pritchard
IPC分类号： A61K38/22 , A61K47/48 , C07K14/575
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
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公开(公告)号：US20140287984A1
公开(公告)日：2014-09-25
申请号：US14355568
申请日：2012-10-30
发明人： Ingo Flamme , Johannes Köbberling , Hans-Georg Lerchen , Nils Griebenow , Rudolf Schohe-Loop , Sven Wittrock , Maria Köllnberger , Frank Wunder , Gorden Redlich , Andreas Knorr , July Marley , Iain Pritchard
CPC分类号： C07K5/06017 , A61K9/007 , A61K38/22 , A61K45/06 , A61K47/60 , C07K5/02 , C07K5/06078 , C07K14/575
摘要： The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
摘要翻译： 本发明涉及基于新型聚乙二醇（PEG）的肾上腺髓质素前药，其制备方法及其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管，水肿和/或炎症性疾病。
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7.发明申请(Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use 有权（氮杂）吡唑并吡咯并嘧啶酮和吲唑并嘧啶酮及其用途公开(公告)号：US20150126449A1
公开(公告)日：2015-05-07
申请号：US14533915
申请日：2014-11-05
发明人： Jorma Haßfeld , Tom KINZEL , Johannes Köbberling , Yolanda CANCHO GRANDE , Kristin BEYER , Susanne Röhrig , Maria Köllnberger , Michael SPERZEL , Nils BURKHARDT , Karl-Heinz SCHLEMMER , Christian STEGMANN , Joachim SCHUHMACHER , Matthias WERNER , Manuel ELLERMANN
IPC分类号： C07D487/04 , C07D471/14 , A61K45/06 , A61K31/519
CPC分类号： A61K31/519 , A61K45/06 , C07D471/14 , C07D487/04 , C07D487/12
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
摘要翻译： 本申请涉及新的取代的（氮杂）吡啶并吡咯并嘧啶酮和吲唑并嘧啶酮，其制备方法，单独使用的化合物或用于治疗和/或预防疾病，特别是用于治疗和/或预防的方法中的组合 具有或不具有潜在遗传性或获得性出血性疾病的患者的急性和复发性出血，其中所述出血与选自月经过多，产后出血，出血性休克，创伤，手术，移植，中风， 肝脏疾病，遗传性血管性水肿，流鼻血和关节炎后的滑膜炎和软骨损伤。
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公开(公告)号：US10118930B2
公开(公告)日：2018-11-06
申请号：US15523954
申请日：2015-10-30
发明人： Manuel Ellermann , Gaelle Valot , Yolanda Cancho Grande , Jorma Haßfeld , Tom Kinzel , Johannes Köbberling , Kristin Beyer , Susanne Röhrig , Michael Sperzel , Jan Stampfuß , Imke Meyer , Maria Köllnberger , Nils Burkhardt , Karl-Heinz Schlemmer , Christian Stegmann , Joachim Schuhmacher , Matthias Werner , Jörg Heiermann , Willem Jan Hengeveld
IPC分类号： A01N43/90 , A61K31/519 , C07D487/04 , C07D471/04 , C07D211/06 , C07D403/14 , C07D231/00 , C07D247/02 , C07D271/06 , C07D271/10
摘要： The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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公开(公告)号：US10098883B2
公开(公告)日：2018-10-16
申请号：US15416651
申请日：2017-01-26
发明人： Jorma Haßfeld , Tom Kinzel , Johannes Köbberling , Yolanda Cancho-Grande , Kristin Beyer , Susanne Röhrig , Maria Köllnberger , Michael Sperzel , Nils Burkhardt , Karl-Heinz Schlemmer , Christian Stegmann , Joachim Schuhmacher , Matthias Werner , Manuel Ellermann
IPC分类号： A61K31/519 , A61K45/06 , C07D487/12 , C07D471/14 , C07D487/04
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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公开(公告)号：US10668071B2
公开(公告)日：2020-06-02
申请号：US16101250
申请日：2018-08-10
发明人： Jorma Haßfeld , Tom Kinzel , Johannes Köbberling , Yolanda Cancho-Grande , Kristin Beyer , Susanne Röhrig , Maria Köllnberger , Michael Sperzel , Nils Burkhardt , Karl-Heinz Schlemmer , Christian Stegmann , Joachim Schuhmacher , Matthias Werner , Manuel Ellermann
IPC分类号： A61K31/519 , A61K45/06 , C07D487/04 , C07D487/12 , C07D471/14
摘要： The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.
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