-
公开(公告)号：US10703742B2
公开(公告)日：2020-07-07
申请号：US16098238
申请日：2017-05-02
发明人： Heiko Schirmer , Philipp Rubenbauer , Hans-Christian Militzer , Marie-Pierre Collin-Kröpelin , Frank Süßmeier , Kersten Matthias Gericke , Thomas Neubauer , Chantal Fürstner
IPC分类号： C07D403/06 , C07D249/12
摘要： The present application relates to a novel and improved process for preparing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives of the formula (I) in which R1A and R1B are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline polymorph I of (5-(4-chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S)-1-hydroxyethyl]-1H-1,2,4-triazol-3-yl}methyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I-A-1).
-
公开(公告)号：US10526314B2
公开(公告)日：2020-01-07
申请号：US16098202
申请日：2017-05-02
发明人： Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Hanna Tinel , Heiko Schirmer
IPC分类号： C07D401/14 , C07D403/14 , C07D417/14 , A61P9/10 , A61P9/12 , A61P13/12 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US09988367B2
公开(公告)日：2018-06-05
申请号：US15581064
申请日：2017-04-28
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06
CPC分类号： C07D401/14 , A61K31/4439 , A61K45/06
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US10472348B2
公开(公告)日：2019-11-12
申请号：US15969222
申请日：2018-05-02
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US09949978B2
公开(公告)日：2018-04-24
申请号：US15288982
申请日：2016-10-07
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： A61K31/506 , A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/536
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
-
公开(公告)号：US09949977B2
公开(公告)日：2018-04-24
申请号：US15288968
申请日：2016-10-07
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： A61K31/506 , A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/536
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
-
公开(公告)号：US10815205B2
公开(公告)日：2020-10-27
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： C07D249/14 , C07D403/06 , A61P9/00 , A61P13/12 , A61K31/4196 , A61K45/06 , C07D249/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US20150148340A1
公开(公告)日：2015-05-28
申请号：US14399945
申请日：2013-05-03
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： C07D417/14 , A61K31/513 , C07D405/14 , A61K45/06 , C07D417/04 , C07D401/04 , C07D409/14 , C07D403/04 , C07D413/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
摘要翻译： 本申请涉及新颖的双环取代的尿嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防 疾病
-
公开(公告)号：US10300062B2
公开(公告)日：2019-05-28
申请号：US15912185
申请日：2018-03-05
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/506 , A61K31/536
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
-
公开(公告)号：US09926305B2
公开(公告)日：2018-03-27
申请号：US15035165
申请日：2014-11-05
发明人： Britta Olenik , Birgit Keil , Martin-Holger Hinz , Chantal Fürstner , Mario Jeske , Jens Ackerstaff
IPC分类号： A61K31/506 , C07D413/04 , C07C229/26
CPC分类号： C07D413/04 , C07C229/26
摘要： Salts of 1-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)-4-(trifluoromethyl) -2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid of the formula (I), in particular amino acid salts such as the lysine salt and alkali metal salts such as the sodium salt and the potassium salt, processes for their preparation, medicaments comprising them and their use for controlling diseases.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.035 秒)
