-
公开(公告)号：US11298367B2
公开(公告)日：2022-04-12
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Hana Cernecka , Karoline Droebner , Hanna Tinel , Anja Buchmueller , Thomas Mondritzki , Axel Kretschmer , Klemens Lustig , Robert Fricke , Guillaume Levilain , Ursula Krenz , Norbert Witowski
IPC分类号： A61K31/675 , A61P13/12 , A61K45/06 , C07F9/6558
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US10525041B2
公开(公告)日：2020-01-07
申请号：US16098255
申请日：2017-05-02
发明人： Thomas Neubauer , Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer
IPC分类号： A61K31/4196 , C07D403/06 , A61P9/10 , A61P13/12 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D249/12
摘要： The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US10428083B2
公开(公告)日：2019-10-01
申请号：US15560265
申请日：2016-03-21
发明人： Michael Härter , Dirk Kosemund , Martina Delbeck , Bernd Kalthof , Pierre Wasnaire , Frank Süβmeier , Klemens Lustig
IPC分类号： A61K31/519 , C07D495/04 , A61K45/06
摘要： The present application relates to novel thieno[2,3-d]pyrimidine-2,4-dione (“thienouracil”) derivatives bearing a particular type of (azaheterocyclyl)methyl substituent, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of pulmonary and cardiovascular disorders and of cancer.
-
公开(公告)号：US09771352B2
公开(公告)日：2017-09-26
申请号：US14930157
申请日：2015-11-02
发明人： Carsten Schmeck , Michael Gerisch , Nils Griebenow , Peter Kolkhof , Florian Kölling , Anna Engelen , Axel Kretschmer , Dieter Lang , Klemens Lustig , Thomas Mondritzki , Elisabeth Pook , Hartmut Beck , Frank Süβmeier , Sonja Vollmer , Pierre Wasnaire
IPC分类号： C07D403/06 , A61K31/4196 , A61K45/06
CPC分类号： C07D249/12 , A61K31/4196 , A61K45/06 , C07D403/06
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
-
公开(公告)号：US11331314B2
公开(公告)日：2022-05-17
申请号：US16758802
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Hanna Tinel , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Klemens Lustig
IPC分类号： A61K31/496 , A61P9/12 , A61K31/4196 , A61K31/422 , A61K31/454 , A61K31/541 , A61K31/55 , A61K45/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US11091463B2
公开(公告)日：2021-08-17
申请号：US16579341
申请日：2019-09-23
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmueller , Hanna Tinel , Karoline Droebner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US10815205B2
公开(公告)日：2020-10-27
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： C07D249/14 , C07D403/06 , A61P9/00 , A61P13/12 , A61K31/4196 , A61K45/06 , C07D249/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
公开(公告)号：US10800746B2
公开(公告)日：2020-10-13
申请号：US16098227
申请日：2017-05-02
发明人： Carsten Schmeck , Anna Engelen , Peter Kolkhof , Klemens Lustig , Elisabeth Pook , Pierre Wasnaire
IPC分类号： C07D249/12 , A61P9/00
摘要： The present invention relates to novel Oxoalkyl-substituted 1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.
-
公开(公告)号：US09963464B2
公开(公告)日：2018-05-08
申请号：US15303212
申请日：2015-04-08
发明人： Ulrich Lücking , Pierre Wasnaire , Arne Scholz , Philip Lienau , Gerhard Siemeister , Christian Stegmann , Ulf Bömer , Kunzeng Zheng , Ping Gao , Gang Chen , Jiajun Xi
IPC分类号： C07D498/14 , C07D498/04 , C07C53/18 , A61K31/4375 , A61K31/519
CPC分类号： C07D498/14 , A61K31/4375 , A61K31/519 , C07C53/18 , C07D498/04
摘要： The present invention relates to novel macrocyclic compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
-
公开(公告)号：US10472348B2
公开(公告)日：2019-11-12
申请号：US15969222
申请日：2018-05-02
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.035 秒)
