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公开(公告)号：US10047096B2
公开(公告)日：2018-08-14
申请号：US15529043
申请日：2015-11-23
发明人： Andreas Schall , Jürgen Klar , Mario Lobell , Hartmut Schirok , Joachim Telser , Steffen Müller , Dirk Brohm , Hans Briem , Hannah Jörißen , Joerg Keldenich , Michael Böttger , Georges Von Degenfeld , Thomas Schlange , Ulf Bömer , Niels Lindner , Hanna Eilken , Dmitrij Hristodorov , Pierre Wasnaire , Kersten Matthias Gericke , Lars Bärfacker
IPC分类号： A61K31/551 , C07D471/04 , C07D487/04 , A61K31/5513 , A61K39/395
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：US10221247B2
公开(公告)日：2019-03-05
申请号：US15691731
申请日：2017-08-30
发明人： Andreas Wilmen , Julia Straßburger , Frank Dittmer , Michael Strerath , Anja Buchmüller , Joanna Grudzinska-Goebel , Ricarda Finnern , Martina Schäfer , Christoph Gerdes , Hannah Jörißen , Asako Itakura , Philberta Y. Leung , Erik Tucker
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
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公开(公告)号：US11046783B2
公开(公告)日：2021-06-29
申请号：US16292196
申请日：2019-03-04
发明人： Andreas Wilmen , Julia Straßburger , Frank Dittmer , Michael Strerath , Anja Buchmüller , Joanna Grudzinska-Goebel , Ricarda Finnern , Martina Schäfer , Christoph Gerdes , Hannah Jörißen , Asako Itakura , Philberta Y. Leung , Erik Tucker
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
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公开(公告)号：US10040866B2
公开(公告)日：2018-08-07
申请号：US15691736
申请日：2017-08-30
发明人： Andreas Wilmen , Julia Straßburger , Frank Dittmer , Michael Strerath , Anja Buchmüller , Joanna Grudzinska-Goebel , Ricarda Finnern , Martina Schäfer , Christoph Gerdes , Hannah Jörißen , Asako Itakura , Philberta Y. Leung , Erik Tucker
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
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5.发明申请Antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and uses thereof 有权能够结合凝血因子XI和/或其活化形式因子XIa的抗体及其用途公开(公告)号：US20150099298A1
公开(公告)日：2015-04-09
申请号：US14400281
申请日：2013-05-08
发明人： Andreas Wilmen , Julia Straßburger , Frank Dittmer , Michael Strerath , Anja Buchmüller , Joanna Grudzinska-Goebel , Ricarda Finnern , Martina Schäfer , Christoph Gerdes , Hannah Jörißen , Asako Itakura , Philberta Leung , Erik Tucker
IPC分类号： C07K16/36
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
摘要翻译： 本发明涉及能够结合凝血因子XI和/或其活化形式因子XIa的抗体及其使用方法，特别是用作抑制血小板聚集的药物的方法，并且由此抑制血栓形成。
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