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1.发明授权Substituted aminoindane- and aminotetralinecarboxylic acids and the use thereof 有权取代的氨基茚满和氨基四氢萘羧酸及其用途公开(公告)号：US09387203B2
公开(公告)日：2016-07-12
申请号：US14414297
申请日：2013-07-16
发明人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner , Eva Maria Becker-Pelster
IPC分类号： A61K31/445 , A61K31/45 , A61K45/06 , A61K31/197 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , C07C255/54 , C07D231/12 , C07C229/50 , C07D263/22 , C07D207/27 , C07D211/76 , A61K31/24 , A61K9/00 , A61K9/20 , C07C227/18 , A61K9/08 , A61K9/10
CPC分类号： A61K31/45 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/2059 , A61K31/197 , A61K31/24 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , A61K45/06 , C07C227/18 , C07C229/50 , C07C255/54 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D211/76 , C07D231/12 , C07D263/22 , A61K2300/00
摘要： The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.
摘要翻译： 本申请涉及新型取代氨基茚满和氨基四氢萘羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管和心肺疾病。
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公开(公告)号：US10053428B2
公开(公告)日：2018-08-21
申请号：US15600132
申请日：2017-05-19
发明人： Michael Hahn , Markus Follmann , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin , Walter Hübsch
IPC分类号： A61K31/4706 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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公开(公告)号：US09505786B2
公开(公告)日：2016-11-29
申请号：US14738148
申请日：2015-06-12
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K31/53 , A61P9/10 , A61P9/12 , A61P7/02 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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4.发明申请SUBSTITUTED BENZOTHIENYL - PYRROLOTRIAZINES AND USES THEREOF IN THE TREATMENT CANCER 有权替代苯扎林 - 吡格列酮及其在治疗癌症中的应用公开(公告)号：US20150080371A1
公开(公告)日：2015-03-19
申请号：US14365024
申请日：2012-12-11
发明人： Marie-Pierre Collin , Dirk Brohm , Melanie Heroult , Mario Lobell , Walter Hübsch , Klemens Lustig , Sylvia Grünewald , Ulf Bömer , Verena Vöhringer , Niels Lindner
IPC分类号： C07D487/04 , A61K31/541 , A61K31/553 , A61K31/551 , A61K31/53 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fJ[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
摘要翻译： 本发明涉及具有蛋白酪氨酸激酶抑制活性的新的取代的5-（1-苯并噻吩-2-基）吡咯并[2,1-f] [1,2,4]三嗪-4-胺衍生物，其制备方法 这种化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗增殖性疾病，特别是癌症和肿瘤疾病的用途。
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公开(公告)号：US09688636B2
公开(公告)日：2017-06-27
申请号：US14609122
申请日：2015-01-29
发明人： Michael Hahn , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/48 , A61K31/4706 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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公开(公告)号：US09598416B2
公开(公告)日：2017-03-21
申请号：US14365024
申请日：2012-12-11
发明人： Marie-Pierre Collin , Dirk Brohm , Mélanie Héroult , Mario Lobell , Walter Hübsch , Klemens Lustig , Sylvia Grünewald , Ulf Bömer , Verena Vöhringer , Niels Lindner
IPC分类号： C07D487/04 , C07D409/04 , C07D409/14 , A61K31/53 , A61K31/382 , A61P35/00 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fJ[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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7.发明申请SUBSTITUTED AMINOINDANE- AND AMINOTETRALINECARBOXYLIC ACIDS AND THE USE THEREOF 有权取代的氨基氨基和氨基甲酰氧基酸及其用途公开(公告)号：US20150174113A1
公开(公告)日：2015-06-25
申请号：US14414297
申请日：2013-07-16
发明人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner , Eva Maria Becker-Pelster
IPC分类号： A61K31/45 , C07C227/18 , A61K31/197 , A61K45/06 , C07D211/76 , A61K31/4015 , C07D263/22 , A61K31/421 , C07D231/12 , A61K31/415 , C07C229/50 , C07D207/27
CPC分类号： A61K31/45 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/2059 , A61K31/197 , A61K31/24 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , A61K45/06 , C07C227/18 , C07C229/50 , C07C255/54 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D211/76 , C07D231/12 , C07D263/22 , A61K2300/00
摘要： The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.
摘要翻译： 本申请涉及新型取代氨基茚满和氨基四氢萘羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管和心肺疾病。
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公开(公告)号：US20140357637A1
公开(公告)日：2014-12-04
申请号：US14371046
申请日：2013-01-10
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K45/06 , A61K31/53 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20150148376A1
公开(公告)日：2015-05-28
申请号：US14609122
申请日：2015-01-29
发明人： Michael HAHN , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , IIdiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/48 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
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公开(公告)号：US08981104B2
公开(公告)日：2015-03-17
申请号：US13945675
申请日：2013-07-18
发明人： Michael Hahn , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/38 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4706 , A61K31/4709 , A61K45/06
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
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