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公开(公告)号：US20140357637A1
公开(公告)日：2014-12-04
申请号：US14371046
申请日：2013-01-10
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K45/06 , A61K31/53 , A61K31/519
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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![3-aryl-substituted imidazo[1,2-A]pyridines and their use](/abs-image/US/2017/10/03/US09776997B2/abs.jpg.150x150.jpg)
公开(公告)号：US09776997B2
公开(公告)日：2017-10-03
申请号：US14895809
申请日：2014-06-04
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Alexey Gromov , Niels Lindner , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li
IPC分类号： A61K31/437 , C07D471/04 , A61K31/506 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/541 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
摘要： The present application relates to novel 3-aryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
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![Cyano-substituted imidazo[1,2-A]pyridinecarboxamides and their use](/abs-image/US/2017/09/26/US09771360B2/abs.jpg.150x150.jpg)
公开(公告)号：US09771360B2
公开(公告)日：2017-09-26
申请号：US15120377
申请日：2015-03-18
发明人： Alexandros Vakalopoulos , Philipp Buchgraber , Niels Lindner , Markus Follmann , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Gorden Redlich , Lisa Dietz , Volkhart Min-Jian Li
IPC分类号： C07D401/02 , C07D401/10 , A61K31/437 , A61K31/4353 , C07D471/04 , A61K45/06 , A61K31/444 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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![Substituted pyrazolo[1,5-A]-pyridine-3-carboxamides and use thereof](/abs-image/US/2016/08/23/US09422285B2/abs.jpg.150x150.jpg)
4.发明授权公开(公告)号：US09422285B2
公开(公告)日：2016-08-23
申请号：US14909881
申请日：2014-08-05
发明人： Alexandros Vakalopoulos , Markus Follmann , Philipp Buchgraber , Alexey Gromov , Ingo Hartung , Niels Lindner , Frank Wunder , Johannes-Peter Stasch , Tobias Marquardt , Gorden Redlich , Lisa Dietz , Volkhart Min-Jian Li
IPC分类号： C07D471/04 , A61K31/437 , A61K45/06 , A61K31/4545 , C07D519/00 , A61K31/4709 , A61K31/55 , A61K31/5377 , A61K31/444 , A61K31/4375 , A61K31/541 , A61K31/496 , A61K31/4985
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D519/00
摘要： The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的吡唑并[1,5-a]吡啶-3-甲酰胺，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用途 用于生产用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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5.发明授权Substituted aminoindane- and aminotetralinecarboxylic acids and the use thereof 有权取代的氨基茚满和氨基四氢萘羧酸及其用途公开(公告)号：US09387203B2
公开(公告)日：2016-07-12
申请号：US14414297
申请日：2013-07-16
发明人： Walter Hübsch , Michael Hahn , Alexandros Vakalopoulos , Volkhart Min-Jian Li , Frank Wunder , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Friederike Stoll , Niels Lindner , Eva Maria Becker-Pelster
IPC分类号： A61K31/445 , A61K31/45 , A61K45/06 , A61K31/197 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , C07C255/54 , C07D231/12 , C07C229/50 , C07D263/22 , C07D207/27 , C07D211/76 , A61K31/24 , A61K9/00 , A61K9/20 , C07C227/18 , A61K9/08 , A61K9/10
CPC分类号： A61K31/45 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/2018 , A61K9/2059 , A61K31/197 , A61K31/24 , A61K31/277 , A61K31/4015 , A61K31/415 , A61K31/421 , A61K45/06 , C07C227/18 , C07C229/50 , C07C255/54 , C07C2602/08 , C07C2602/10 , C07D207/27 , C07D211/76 , C07D231/12 , C07D263/22 , A61K2300/00
摘要： The present application relates to novel substituted aminoindane- and aminotetralinecarboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary diseases.
摘要翻译： 本申请涉及新型取代氨基茚满和氨基四氢萘羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管和心肺疾病。
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![Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2015/02/03/US08946215B2/abs.jpg.150x150.jpg)
6.发明授权公开(公告)号：US08946215B2
公开(公告)日：2015-02-03
申请号：US14071274
申请日：2013-11-04
发明人： Alexandros Vakalopoulos , Ingo Hartung , Markus Follmann , Rolf Jautelat , Alexander Straub , Jorma Haβfeld , Niels Lindner , Dirk Schneider , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： C07D401/02 , C07D401/10 , A61K31/4353 , C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use](/abs-image/US/2014/07/15/US08778964B2/abs.jpg.150x150.jpg)
公开(公告)号：US08778964B2
公开(公告)日：2014-07-15
申请号：US13789208
申请日：2013-03-07
发明人： Alexandros Vakalopoulos , Ingo Hartung , Markus Follmann , Rolf Jautelat , Alexander Straub , Jorma Haβfeld , Niels Lindner , Dirk Schneider , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva-Maria Becker , Andreas Knorr
IPC分类号： A61K31/44 , C07D491/02 , C07D498/02
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2017/04/18/US09624214B2/abs.jpg.150x150.jpg)
公开(公告)号：US09624214B2
公开(公告)日：2017-04-18
申请号：US14070180
申请日：2013-11-01
发明人： Alexandros Vakalopoulos , Markus Follmann , Ingo Hartung , Philipp Buchgraber , Rolf Jautelat , Jorma Haβfeld , Niels Lindner , Alexey Gromov , Frank Wunder , Johannes-Peter Stasch , Gorden Redlich , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Andreas Knorr
IPC分类号： A61K31/4353 , C07D471/04 , A61K31/437 , A61K31/439 , A61K31/4985 , A61K45/06 , C07D471/08 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D519/00
CPC分类号： A61K31/437 , A61K31/439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D471/08 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US09505786B2
公开(公告)日：2016-11-29
申请号：US14738148
申请日：2015-06-12
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K31/53 , A61P9/10 , A61P9/12 , A61P7/02 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US10927109B2
公开(公告)日：2021-02-23
申请号：US16333079
申请日：2017-09-06
发明人： Henrik Teller , Alexandros Vakalopoulos , Melissa Boultadakis Arapinis , Alexander Straub , Hanna Tinel , Markus Brechmann , Matthias Beat Wittwer , Maximilian Andreas Kullmann , Till Freudenberger , Thomas Mondritzki , Tobias Marquardt
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/06 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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