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公开(公告)号：US11963979B2
公开(公告)日：2024-04-23
申请号：US16016305
申请日：2018-06-22
发明人： Rainer Ludwig Knaus , Katy Rebecca Newton , Juan Vera , Ann Leen , Cliona Rooney , John R. Wilson
IPC分类号： A61K35/17 , A61K39/12 , A61K39/235 , A61K39/245 , C12M1/04 , C12N5/0783 , C12N7/00 , A61K39/00
CPC分类号： A61K35/17 , A61K39/12 , A61K39/235 , A61K39/245 , C12M23/24 , C12N5/0636 , C12N7/00 , A61K2039/5158 , A61K2039/55527 , C12N2501/2304 , C12N2501/2307 , C12N2506/11 , C12N2710/10034 , C12N2710/16134 , C12N2710/18034 , Y02A50/30
摘要： An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific T cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.
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2.发明授权公开(公告)号：US10385316B2
公开(公告)日：2019-08-20
申请号：US15246241
申请日：2016-08-24
IPC分类号： C12N5/00 , A61K38/00 , A61K39/00 , C12N5/02 , C12N5/0783 , A61K39/12 , A61K39/155 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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3.发明申请公开(公告)号：US20220282218A1
公开(公告)日：2022-09-08
申请号：US17804239
申请日：2022-05-26
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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4.发明申请公开(公告)号：US20190264176A1
公开(公告)日：2019-08-29
申请号：US16408093
申请日：2019-05-09
IPC分类号： C12N5/0783 , A61K39/155 , A61K39/00 , A61K39/12 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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5.发明申请GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES 审中-公开具有针对多种肿瘤抗原或多种病毒的特异性的CTL系的产生公开(公告)号：US20160362658A1
公开(公告)日：2016-12-15
申请号：US15246241
申请日：2016-08-24
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/155 , A61K39/245 , A61K39/12
CPC分类号： C12N5/0638 , A61K39/0011 , A61K39/12 , A61K39/155 , A61K39/245 , A61K2039/5158 , A61K2039/54 , A61K2039/572 , C12N5/0636 , C12N2501/23 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2502/11
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
摘要翻译： 本发明包括用于产生和使用靶向多种病毒或对多种肿瘤抗原特异的细胞毒性T淋巴细胞的方法和组合物。 在具体实施方案中，生成方法使用某些细胞因子来促进活化的T细胞群体中的增殖和减少细胞死亡，和/或使用具有透气膜的特定生物反应器。
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公开(公告)号：US11999969B2
公开(公告)日：2024-06-04
申请号：US18511208
申请日：2023-11-16
发明人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
IPC分类号： C12N5/0783 , C12M1/04
CPC分类号： C12N5/0638 , C12M23/24 , C12N2501/2302 , C12N2502/11
摘要： An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
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公开(公告)号：US10533156B2
公开(公告)日：2020-01-14
申请号：US15395662
申请日：2016-12-30
发明人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
IPC分类号： C12N5/0783 , C12M1/04
摘要： An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
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公开(公告)号：US11821002B2
公开(公告)日：2023-11-21
申请号：US17688477
申请日：2022-03-07
发明人： Juan F. Vera , Cliona M. Rooney , Ann M. Leen , John R. Wilson
IPC分类号： C12N5/0783 , C12M1/04
CPC分类号： C12N5/0638 , C12M23/24 , C12N2501/2302 , C12N2502/11
摘要： An improved method of culturing cells for cell therapy applications that includes growing desired cells in the presence of antigen-presenting cells and/or feeder cells and with medium volume to surface area ratio of up to 1 ml/cm2 if the growth surface is not comprised of gas permeable material and up to 2 ml/cm2 if the growth surface is comprised of gas permeable material. The desired cells are at a surface density of less than 0.5×106 cells/cm2 at the onset of a production cycle, and the surface density of the desired cells plus the surface density of the antigen presenting cells and/or feeder cells are at least about 1.25×105 cells/cm2.
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9.发明公开公开(公告)号：US20230357721A1
公开(公告)日：2023-11-09
申请号：US18354308
申请日：2023-07-18
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/245
CPC分类号： C12N5/0638 , C12N5/0636 , A61K39/0011 , A61K39/12 , A61K39/155 , A61K39/245 , C12N2501/23 , A61K2039/5158 , A61K2039/54 , A61K2039/572 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2312 , C12N2501/2315 , C12N2502/11
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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10.发明申请公开(公告)号：US20230114971A1
公开(公告)日：2023-04-13
申请号：US18062452
申请日：2022-12-06
IPC分类号： C12N5/0783 , A61K39/00 , A61K39/12 , A61K39/155 , A61K39/245
摘要： The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In specific embodiments, the generation methods employ use of certain cytokines to promote proliferation and reduce cell death in an activated T cell population and/or that employ a particular bioreactor having a gas permeable membrane.
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