公开(公告)号：US20180038829A1

公开(公告)日：2018-02-08

申请号：US15783388

申请日：2017-10-13

Applicant: Beckman Coulter, Inc.

Inventor： Brian D. Peterson ,  Dale Alan Owens ,  Peter S. Kotowski ,  Sunil S. Deliwala ,  Craig A. Hudson ,  James H. Reyes ,  Clive Cheung ,  Tom Tran ,  Anna X. Lou ,  Jane Luo ,  Jean-Marc Rene Lucien Busnel ,  Chitra K. Ratnayake

IPC: G01N27/447 ,  H01J49/02 ,  G01N30/72 ,  H01J49/16

CPC classification number: G01N27/44743 ,  G01N27/44717 ,  G01N30/7266 ,  H01J49/022 ,  H01J49/165 ,  Y10T307/313

Abstract: Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems.

公开(公告)号：US09927396B2

公开(公告)日：2018-03-27

申请号：US14354489

申请日：2012-10-26

Applicant: Beckman Coulter, Inc.

Inventor： Brian D. Peterson ,  Dale Alan Owens ,  Peter S. Kotowski ,  Sunil S. Deliwala ,  Craig A. Hudson ,  James H. Reyes ,  Clive Cheung ,  Tom Tran ,  Anna X. Lou ,  Jane Luo ,  Jean-Marc Rene Lucien Busnel ,  Chitra K. Ratnayake

IPC: G01N27/447 ,  G01N30/72 ,  H01J49/02 ,  H01J49/16

CPC classification number: G01N27/44743 ,  G01N27/44717 ,  G01N30/7266 ,  H01J49/022 ,  H01J49/165 ,  Y10T307/313

Abstract: Aspects of the innovations presented herein relate to improved systems that in some embodiments perform capillary electrophoresis (CE) and CE in conjunction with electrospray ionization (ESI) as an input to a mass spectrometry system (MS). Some embodiments use a high voltage isolated CE power supply that is configured to float on the high voltage output of an ESI-MS power supply, with a protective resistance in the ESI-MS path, as well as DC/DC converter isolation and communication system isolation for the isolated CE power supply. Some embodiments additionally use a cartridge assembly integrating separation and conductive fluid capillaries with fluid cooling and protective retractable housings for the capillary end portions and for the ESI output. The protective housing may further be used with an adapter for interfacing with different MS systems.