公开(公告)号：US09574057B2

公开(公告)日：2017-02-21

申请号：US14388886

申请日：2013-03-28

Applicant: Becton, Dickinson and Company

Inventor： Javier Alarcon

IPC: C08F2/46 ,  C08F2/50 ,  C08G61/04 ,  C08J7/18 ,  A61B5/145 ,  A61B5/1455 ,  G01N33/66 ,  C07K17/04

CPC classification number: C08J7/18 ,  A61B5/14532 ,  A61B5/14556 ,  A61B2562/028 ,  C07K17/04 ,  C08J2323/12 ,  C08J2325/06 ,  C08J2367/02 ,  C08J2367/03 ,  C08J2369/00 ,  G01N33/66

Abstract: Methods for adhering a hydrogel matrix to a molded polymer substrate and its use as a biosensor, e.g., a continuous or episodic glucose monitor, are disclosed. The presently disclosed subject matter provides a method for adhering a hydrogel matrix to a molded polymer substrate, the method comprising: (a) molding a polymer comprising one or more polymer chains with an oxidizer to form a molded polymer substrate; (b) providing a hydrogel matrix comprising a hydrogel, a component comprising one or more acrylate groups or another functional group that can form one or more radicals upon polymerization in the molded polymer substrate, and a photo initiator; (c) combining the molded polymer substrate and the hydrogel matrix; and (d) curing the combined molded polymer substrate and hydrogel matrix for a period of time.

Abstract translation: 公开了将水凝胶基质粘附到模制聚合物基底上的方法及其作为生物传感器（例如连续或间歇性葡萄糖监测器）的用途。 目前公开的主题提供了一种将水凝胶基体粘附到模制的聚合物基底上的方法，该方法包括：（a）用氧化剂将包含一个或多个聚合物链的聚合物模制成模制聚合物基底; （b）提供包含水凝胶的水凝胶基质，包含一种或多种丙烯酸酯基团的组分或在模制的聚合物基材中聚合时可以形成一个或多个基团的另一官能团和光引发剂; （c）将模制的聚合物基底和水凝胶基体结合; 和（d）将组合的模制的聚合物基质和水凝胶基质固化一段时间。

公开(公告)号：US20150025170A1

公开(公告)日：2015-01-22

申请号：US14388886

申请日：2013-03-28

Applicant: Becton, Dickinson and Company

Inventor： Javier Alarcon

IPC: C08J7/18 ,  G01N33/66

CPC classification number: C08J7/18 ,  A61B5/14532 ,  A61B5/14556 ,  A61B2562/028 ,  C07K17/04 ,  C08J2323/12 ,  C08J2325/06 ,  C08J2367/02 ,  C08J2367/03 ,  C08J2369/00 ,  G01N33/66

Abstract: Methods for adhering a hydrogel matrix to a molded polymer substrate and its use as a biosensor, e.g., a continuous or episodic glucose monitor, are disclosed. The presently disclosed subject matter provides a method for adhering a hydrogel matrix to a molded polymer substrate, the method comprising: (a) molding a polymer comprising one or more polymer chains with an oxidizer to form a molded polymer substrate; (b) providing a hydrogel matrix comprising a hydrogel, a component comprising one or more acrylate groups or another functional group that can form one or more radicals upon polymerization in the molded polymer substrate, and a photo initiator; (c) combining the molded polymer substrate and the hydrogel matrix; and (d) curing the combined molded polymer substrate and hydrogel matrix for a period of time.

Abstract translation: 公开了将水凝胶基质粘附到模制聚合物基底上的方法及其作为生物传感器（例如连续或间歇性葡萄糖监测器）的用途。 目前公开的主题提供了一种将水凝胶基体粘附到模制的聚合物基底上的方法，该方法包括：（a）用氧化剂将包含一个或多个聚合物链的聚合物模制成模制聚合物基底; （b）提供包含水凝胶的水凝胶基质，包含一种或多种丙烯酸酯基团的组分或在模制的聚合物基材中聚合时可以形成一个或多个基团的另一官能团和光引发剂; （c）将模制的聚合物基底和水凝胶基体结合; 和（d）将组合的模制的聚合物基质和水凝胶基质固化一段时间。

公开(公告)号：US20150056634A1

公开(公告)日：2015-02-26

申请号：US14388957

申请日：2013-03-28

Applicant: Becton, Dickinson and Company

Inventor： Matthew S. Ferriter ,  Javier Alarcon ,  Glenn P. Vonk ,  Melody M.H. Kuroda ,  Mark Foster Sistare ,  Brandi Marie Ford

IPC: G01N33/66 ,  C07K14/245

CPC classification number: G01N33/66 ,  A61K38/17 ,  C07K14/245

Abstract: Methods and compositions for preparing dry formulations of Glucose Binding Proteins (GBPs) are disclosed. The GBPs may be stored as a dry formulation without significant loss of activity. After reconstitution, the GBPs may be used to determine the glucose concentration of a sample.

Abstract translation: 公开了制备葡萄糖结合蛋白（GBP）干制剂的方法和组合物。 GBP可以作为干燥制剂储存而不会显着损失活性。 重建后，GBP可用于测定样品的葡萄糖浓度。

公开(公告)号：US11672907B2

公开(公告)日：2023-06-13

申请号：US16609657

申请日：2018-05-01

Applicant: Becton, Dickinson and Company

Inventor： Matthew Novak ,  Alfred J. Harvey ,  Douglas B. Sherman ,  Robert J. Radford ,  Javier Alarcon ,  Ronald J. Pettis ,  Kelly Magee Riley

IPC: A61M5/165 ,  A61M5/31

CPC classification number: A61M5/165 ,  A61M5/3145 ,  A61M2205/759

Abstract: Provided herein are devices, systems, and methods for the removal of preservatives/excipients/stabilizers from pharmaceutical preparations/medicaments. The devices and systems include a resin for the filtering of preservatives from pharmaceutical preparations. The methods allow for a period of time of incubation of the pharmaceutical preparation in the resin that effectively removes preservatives, while at the same time maintaining the required amount or concentration of active compound in the preparation. Also provided herein are devices, systems, and methods for the controlled release of anti-inflammatory agents in an insulin infusion set.