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公开(公告)号：US10739248B2
公开(公告)日：2020-08-11
申请号：US16179646
申请日：2018-11-02
Applicant: Becton, Dickinson and Company
Inventor： Joseph Trotter , Sujata Iyer
Abstract: Methods and systems are disclosed for controlling a particle analyzer based at least in part on a generated entrainment factor for a sample. The features include flowing a sample with a series of particles through the particle analyzer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the particle analyzer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.
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公开(公告)号：US10190963B2
公开(公告)日：2019-01-29
申请号：US14170409
申请日：2014-01-31
Applicant: Becton Dickinson and Company
Inventor： Joseph Trotter , Sujata Iyer
Abstract: Methods and systems are disclosed for generating an entrainment factor in a flow cytometry sample. The methods comprise flowing a sample with a series of particles through the flow cytometer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the flow cytometer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.
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公开(公告)号：US20190072478A1
公开(公告)日：2019-03-07
申请号：US16179646
申请日：2018-11-02
Applicant: Becton, Dickinson and Company
Inventor： Joseph Trotter , Sujata Iyer
IPC: G01N15/14
CPC classification number: G01N15/1459 , G01N15/1404 , G01N2015/1006 , G01N2015/149
Abstract: Methods and systems are disclosed for controlling a particle analyzer based at least in part on a generated entrainment factor for a sample. The features include flowing a sample with a series of particles through the particle analyzer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the particle analyzer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.
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4.发明申请公开(公告)号：US20140216128A1
公开(公告)日：2014-08-07
申请号：US14170409
申请日：2014-01-31
Applicant: BECTON DICKINSON AND COMPANY
Inventor： Joseph Trotter , Sujata Iyer
IPC: G01N15/00
CPC classification number: G01N15/1459 , G01N15/1404 , G01N2015/1006 , G01N2015/149
Abstract: Methods and systems are disclosed for generating an entrainment factor in a flow cytometry sample. The methods comprise flowing a sample with a series of particles through the flow cytometer, detecting events and calculating an expected frequency of those events based on a distribution, such as a Poisson distribution, and measuring an observed frequency of particle events. An entrainment factor may be generated from a ratio of observed event frequency to expected event frequency. Further adjustment to the flow cytometer maybe performed based on the indicated entrainment factor such as adjusted sorting bias.
Abstract translation: 公开了用于在流式细胞术样品中产生夹带因子的方法和系统。 所述方法包括使具有一系列颗粒的样品流过流式细胞仪，基于诸如泊松分布的分布来检测事件和计算那些事件的预期频率，以及测量观察到的粒子事件的频率。 可以从观察到的事件频率与预期事件频率的比率产生夹带因子。 可以基于所指示的夹带因子（例如经调整的分选偏差）进行对流式细胞仪的进一步调整。
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