公开(公告)号：USD619245S1

公开(公告)日：2010-07-06

申请号：US29353490

申请日：2010-01-08

申请人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith

设计人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith

公开(公告)号：US08328757B2

公开(公告)日：2012-12-11

申请号：US12684566

申请日：2010-01-08

申请人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith ,  Jake W. Myre

发明人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith ,  Jake W. Myre

IPC分类号： A61M37/01

CPC分类号： A61M37/0015 ,  A61M2037/0023

摘要： A bladder arrangement is provided for a microneedle-based drug delivery device. The bladder arrangement includes a flexible membrane having an inner surface, an outer surface and an outer periphery. A bladder member, having a rigidity greater than the flexible membrane, includes an inner surface, an outer surface and an outer periphery. The inner surface of the flexible membrane and the inner surface of the bladder member define a chamber for receiving a drug therein. At least one microneedle is operatively connected to the bladder member. The at least one microneedle has an input and an output receivable within the individual. A valve operatively connects the input of the at least one microneedle and the chamber.

摘要翻译： 为基于微针的药物输送装置提供膀胱装置。 囊状结构包括具有内表面，外表面和外周边的柔性膜。 具有大于柔性膜的刚性的囊状构件包括内表面，外表面和外周。 柔性膜的内表面和气囊构件的内表面限定了用于在其中接收药物的腔室。 至少一个微针可操作地连接到膀胱构件。 至少一个微针具有在个体内的输入和输出可接收。 阀可操作地连接至少一个微针的输入和腔室。

公开(公告)号：USD638534S1

公开(公告)日：2011-05-24

申请号：US29353489

申请日：2010-01-08

申请人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith

设计人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D. S. Smith

公开(公告)号：US20110172601A1

公开(公告)日：2011-07-14

申请号：US12684566

申请日：2010-01-08

申请人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith ,  Jake W. Myre

发明人： David J. Beebe ,  Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith ,  Jake W. Myre

IPC分类号： A61M5/142 ,  A61M5/14 ,  A61M5/168

CPC分类号： A61M37/0015 ,  A61M2037/0023

摘要： A bladder arrangement is provided for a microneedle-based drug delivery device. The bladder arrangement includes a flexible membrane having an inner surface, an outer surface and an outer periphery. A bladder member, having a rigidity greater than the flexible membrane, includes an inner surface, an outer surface and an outer periphery. The inner surface of the flexible membrane and the inner surface of the bladder member define a chamber for receiving a drug therein. At least one microneedle is operatively connected to the bladder member. The at least one microneedle has an input and an output receivable within the individual. A valve operatively connects the input of the at least one microneedle and the chamber.

摘要翻译： 为基于微针的药物输送装置提供膀胱装置。 囊状结构包括具有内表面，外表面和外周边的柔性膜。 具有大于柔性膜的刚性的囊状构件包括内表面，外表面和外周。 柔性膜的内表面和气囊构件的内表面限定了用于在其中接收药物的腔室。 至少一个微针可操作地连接到膀胱构件。 至少一个微针具有在个体内的输入和输出可接收。 阀可操作地连接至少一个微针的输入和腔室。

公开(公告)号：US20110172639A1

公开(公告)日：2011-07-14

申请号：US12684844

申请日：2010-01-08

申请人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

发明人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

IPC分类号： A61M5/32

CPC分类号： A61M37/0015 ,  A61M5/14224 ,  A61M5/14248 ,  A61M5/14586 ,  A61M5/14593 ,  A61M5/42 ,  A61M5/46 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0061

摘要： A device for delivering a drug into the skin of a subject is provided. The device includes a drug reservoir and a microneedle having a tip, a length, and a tip sharpness. The microneedle is coupled to the reservoir. The device includes a microneedle actuator coupled to the microneedle configured to drive the microneedle into the skin of the subject upon activation. The tip sharpness and the actuator allow the microneedle to pass through an outer layer of the skin upon activation, and the length is limited such that the tip does not extend past a desired depth below the surface of the skin of the subject, wherein the desired depth is located in the papillary dermis or the reticular dermis.

摘要翻译： 提供了用于将药物递送到受试者皮肤的装置。 该装置包括药物储存器和具有尖端，长度和尖端锋利度的微针。 微针联接到储存器。 该装置包括耦合到该微针的微针致动器，该微针被配置为在激活时将微针驱动到被摄体的皮肤中。 尖端锐度和致动器允许微针在激活时通过皮肤的外层，并且长度受到限制，使得尖端不延伸超过受试者皮肤表面下方的期望深度，其中期望的 深度位于乳头真皮或网状真皮。

公开(公告)号：US20110172645A1

公开(公告)日：2011-07-14

申请号：US12684832

申请日：2010-01-08

申请人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

发明人： Benjamin J. Moga ,  Kent B. Chase ,  Garrick D.S. Smith

IPC分类号： A61K9/22

CPC分类号： A61K9/0021 ,  A61K9/703 ,  A61M5/14224 ,  A61M5/14248 ,  A61M5/14586 ,  A61M5/14593 ,  A61M37/0015 ,  A61M2037/0023

摘要： A drug delivery device for delivering a drug to a subject is provided. The drug delivery device includes a housing, a drug reservoir supported by the housing containing the drug and a hollow microneedle supported by the housing. The hollow microneedle is moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle. The channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle. The channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position.

摘要翻译： 提供了用于将药物递送到受试者的药物递送装置。 药物输送装置包括壳体，由容纳药物的壳体支撑的药物储存器和由壳体支撑的中空微针。 空心微针可以从非活动位置移动到激活位置，其中当中空微针移动到激活位置时，中空微针的顶端部分被构造成穿透被检体的皮肤。 药物输送装置包括具有与药物储存器连通的输入的通道和与中空微针连通的输出。 通道提供药物储存器和中空微针之间的流体连通，使得药物被允许从药物储存器流过通道并通过中空微针。 当空心微针从非活动位置移动到激活位置时，通道从第一位置移动到第二位置，并且当空心微针从非活动位置移动到激活状态时，药物储存器相对于外壳的位置保持固定 位置。

公开(公告)号：US08795259B2

公开(公告)日：2014-08-05

申请号：US12184632

申请日：2008-08-01

申请人： David J. Beebe ,  Benjamin J. Moga ,  Tony Escarcega ,  Kent Chase

发明人： David J. Beebe ,  Benjamin J. Moga ,  Tony Escarcega ,  Kent Chase

IPC分类号： A61K9/22

CPC分类号： A61M5/14248 ,  A61M5/148 ,  A61M2005/14252

摘要： A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a hydrogel engageable with the reservoir. The hydrogel is movable between a first configuration and a second configuration wherein the hydrogel exerts a pressure on the reservoir to urge the drug therefrom in response to a predetermined stimulus. A flow guide distributes the predetermined stimulus over the hydrogel in response to activation by an individual.

摘要翻译： 提供药物递送平台用于将受控的药物输注输送给个体。 药物递送平台包括用于在其中接收药物的储存器和可与贮存器接合的水凝胶。 水凝胶可以在第一构型和第二构型之间移动，其中水凝胶对贮存器施加压力以响应于预定的刺激来推动药物。 流动引导件响应于个人的激活而将预定的刺激分配在水凝胶上。

公开(公告)号：US08888757B2

公开(公告)日：2014-11-18

申请号：US12473028

申请日：2009-05-27

申请人： Benjamin J. Moga ,  David J. Beebe

发明人： Benjamin J. Moga ,  David J. Beebe

IPC分类号： A61M31/00 ,  A61B17/20 ,  A61M5/00 ,  A61M25/00 ,  A61M5/32 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A61M2037/0046

摘要： An active microneedle array and method are provided for penetrating an outer layer of an epidermis. The active microneedle array includes a base having first and second sides. The first side of the base is engageable with the epidermis. A microneedle projects from the first side of the base. The microneedle is moveable between a first initial configuration and a second deformed configuration in response to engagement with the epidermis so as to form a passageway therein.

摘要翻译： 提供活性微针阵列和方法用于穿透表皮的外层。 活性微针阵列包括具有第一和第二侧面的基底。 基部的第一侧可与表皮接触。 一根微针从基地的第一侧突出。 响应于与表皮的接合，微针可以在第一初始构型和第二变形构型之间移动，以在其中形成通道。

公开(公告)号：US20100030156A1

公开(公告)日：2010-02-04

申请号：US12184632

申请日：2008-08-01

申请人： David J. Beebe ,  Benjamin J. Moga ,  Tony Escarcega ,  Kent Chase

发明人： David J. Beebe ,  Benjamin J. Moga ,  Tony Escarcega ,  Kent Chase

IPC分类号： A61M5/14

CPC分类号： A61M5/14248 ,  A61M5/148 ,  A61M2005/14252

摘要： A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a hydrogel engageable with the reservoir. The hydrogel is movable between a first configuration and a second configuration wherein the hydrogel exerts a pressure on the reservoir to urge the drug therefrom in response to a predetermined stimulus. A flow guide distributes the predetermined stimulus over the hydrogel in response to activation by an individual.

摘要翻译： 提供药物递送平台用于将受控的药物输注输送给个体。 药物递送平台包括用于在其中接收药物的储存器和可与贮存器接合的水凝胶。 所述水凝胶可在第一构型和第二构型之间移动，其中所述水凝胶响应于预定的刺激而在所述储器上施加压力以促使所述药物。 流动引导件响应于个人的激活而将预定的刺激分配在水凝胶上。

公开(公告)号：US20100305518A1

公开(公告)日：2010-12-02

申请号：US12473028

申请日：2009-05-27

申请人： Benjamin J. Moga ,  David J. Beebe

发明人： Benjamin J. Moga ,  David J. Beebe

IPC分类号： A61M5/50

CPC分类号： A61M37/0015 ,  A61M2037/0046

摘要： An active microneedle array and method are provided for penetrating an outer layer of the epidermis. The active microneedle array includes a base having first and second sides. The first side of the base is engageable with the epidermis. A microneedle projects from the first side of the base. The microneedle is moveable between a first initial configuration and a second deformed configuration in response to engagement with the epidermis so as to form a passageway therein.

摘要翻译： 提供一种活性微针阵列和方法，用于穿透表皮的外层。 活性微针阵列包括具有第一和第二侧面的基底。 基部的第一侧可与表皮接触。 一根微针从基地的第一侧突出。 响应于与表皮的接合，微针可以在第一初始构型和第二变形构型之间移动，以在其中形成通道。