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1.发明授权Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties 失效制备具有抗病毒性能的取代1,3-氧硫杂环戊烷的方法公开(公告)号：US06831174B2
公开(公告)日：2004-12-14
申请号：US09760380
申请日：2001-01-16
申请人： Bernard Belleau , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
发明人： Bernard Belleau , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
IPC分类号： C07D41104
CPC分类号： C07D327/04 , C07D405/04 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/40
摘要： Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
摘要翻译： 公开了制备式（I）化合物及其药学上可接受的盐或酯的方法：其中R2是嘌呤或嘧啶碱基或其类似物或衍生物; Z为S，S = O或SO 2。 本发明还涉及用于制备这些化合物的中间体。
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2.发明授权Processes for preparing substituted 1,3-oxathiolanes with antiviral properties 失效制备具有抗病毒性质的取代1,3-氧硫杂环戊烷的方法
公开(公告)号：US5466806A
公开(公告)日：1995-11-14
申请号：US40163
申请日：1993-03-29
申请人： Bernard Belleau, deceased , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
发明人： Bernard Belleau, deceased , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
IPC分类号： C07D327/04 , C07D405/04 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/40 , C07D409/00 , C07F5/02
CPC分类号： C07D411/14 , C07D327/04 , C07D405/04 , C07D411/04 , C07D473/00 , C07D473/40
摘要： Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
摘要翻译： 公开了制备式（I）化合物及其药学上可接受的盐或酯的方法：其中R2是嘌呤或嘧啶碱基或其类似物或衍生物; Z为S，S = O或SO 2。 本发明还涉及用于制备这些化合物的中间体。
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3.发明授权Processes for preparing substituted 1,3-oxathiolanes with antiviral properties 失效制备具有抗病毒性质的取代1,3-氧硫杂环戊烷的方法公开(公告)号：US06175008B1
公开(公告)日：2001-01-16
申请号：US08466329
申请日：1995-06-06
申请人： Bernard Belleau , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
发明人： Bernard Belleau , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
IPC分类号： C07D32704
CPC分类号： C07D327/04 , C07D405/04 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/40
摘要： Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
摘要翻译： 公开了制备式（I）化合物及其药学上可接受的盐或酯的方法：其中R2是嘌呤或嘧啶碱基或其类似物或衍生物; Z为S，S = O或SO 2。 本发明还涉及用于制备这些化合物的中间体。
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4.发明授权Processes for preparing substituted 1,3-oxathiolanes with antiviral properties 失效制备具有抗病毒性质的取代1,3-氧硫杂环戊烷的方法
公开(公告)号：US5684164A
公开(公告)日：1997-11-04
申请号：US468548
申请日：1995-06-06
申请人： Bernard Belleau, deceased , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
发明人： Bernard Belleau, deceased , Tarek Mansour , Allan Tse , Colleen A. Evans , Haolun Jin , Boulos Zacharie , Nghe Nguyen-Ba
IPC分类号： C07D327/04 , C07D405/04 , C07D411/02 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/02 , C07D473/40
CPC分类号： C07D327/04 , C07D405/04 , C07D411/04 , C07D411/14 , C07D473/00 , C07D473/40
摘要： Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
摘要翻译： 公开了制备式（I）化合物及其药学上可接受的盐或酯的方法：其中R2是嘌呤或嘧啶碱基或其类似物或衍生物; Z为S，S = O或SO 2。 本发明还涉及用于制备这些化合物的中间体。
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