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    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
    2.
    发明授权
    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors 有权
    咪唑化合物及其作为α-2肾上腺素能受体的用途

    公开(公告)号：US08188126B2

    公开(公告)日：2012-05-29

    申请号：US12785708

    申请日：2010-05-24

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： A61K31/4164

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Imidazolic compounds and use thereof as alpha-2-adrenergic receptors
    3.
    发明授权
    Imidazolic compounds and use thereof as alpha-2-adrenergic receptors 有权
    咪唑化合物及其作为α-2-肾上腺素能受体的用途

    公开(公告)号：US07220866B2

    公开(公告)日：2007-05-22

    申请号：US10514487

    申请日：2003-05-15

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： C07D233/64

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides compounds having the formula (1): wherein R1 is hydrogen, fluoro or methoxyl, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or methyl; R3 is hydrogen, methyl or ethyl; and their pharmaceutically acceptable acid addition salts, hydrates of their pharmaceutically acceptable acid addition salts as well as the isomers and the tautomers thereof.

    摘要翻译： 本发明提供具有式（1）的化合物：其中R 1是氢，氟或甲氧基，R 1在芳族碳环的2,3,4或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐，其药学上可接受的酸加成盐的水合物及其异构体和互变异构体。

    IMIDAZOLIC COMPOUNDS AND USE THEREOF AS ALPHA-2 ADRENERGIC RECEPTORS
    4.
    发明申请
    IMIDAZOLIC COMPOUNDS AND USE THEREOF AS ALPHA-2 ADRENERGIC RECEPTORS 有权
    咪唑类化合物及其作为ALPHA-2 ADRENERGIC受体的用途

    公开(公告)号：US20110021589A1

    公开(公告)日：2011-01-27

    申请号：US12785708

    申请日：2010-05-24

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： A61K31/4164 ,  A61P25/16 ,  A61P25/28

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
    5.
    发明授权
    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors 有权
    咪唑化合物及其作为α-2肾上腺素能受体的用途

    公开(公告)号：US07776901B2

    公开(公告)日：2010-08-17

    申请号：US11783079

    申请日：2007-04-05

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： A61K31/4164

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
    6.
    发明申请
    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors 有权
    咪唑化合物及其作为α-2肾上腺素能受体的用途

    公开(公告)号：US20070197793A1

    公开(公告)日：2007-08-23

    申请号：US11783079

    申请日：2007-04-05

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： C07D293/02

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments
    10.
    发明授权
    Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments 有权
    芳基 - [4-卤代-4（杂芳基甲基氨基） - 甲基] - 哌啶-1-基] - 甲酮衍生物，其制备方法和药物用途

    公开(公告)号：US07547700B2

    公开(公告)日：2009-06-16

    申请号：US10518394

    申请日：2003-06-18

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Jean-Louis Maurel ,  Francis Colpaert

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Jean-Louis Maurel ,  Francis Colpaert

    IPC分类号： A61K31/501

    CPC分类号： C07D401/12

    摘要： The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.

    摘要翻译： 本发明涉及通式（1）的化合物，其中X和Y =具有键合氢原子（CH）或氮原子的碳，A =甲基，氟甲基，氰基，羟基，甲氧基或氯或 条件是当A =甲基（CH 3）和X和Y都是与氢原子键合的碳时，则B =氯原子，B =氯或氟原子，D =氢，氯，氟 原子或氰基或三氟甲基，E =氢，氟或氯原子。