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    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
    2.
    发明授权
    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors 有权
    咪唑化合物及其作为α-2肾上腺素能受体的用途

    公开(公告)号：US08188126B2

    公开(公告)日：2012-05-29

    申请号：US12785708

    申请日：2010-05-24

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： A61K31/4164

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Imidazolic compounds and use thereof as alpha-2-adrenergic receptors
    3.
    发明授权
    Imidazolic compounds and use thereof as alpha-2-adrenergic receptors 有权
    咪唑化合物及其作为α-2-肾上腺素能受体的用途

    公开(公告)号：US07220866B2

    公开(公告)日：2007-05-22

    申请号：US10514487

    申请日：2003-05-15

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： C07D233/64

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides compounds having the formula (1): wherein R1 is hydrogen, fluoro or methoxyl, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or methyl; R3 is hydrogen, methyl or ethyl; and their pharmaceutically acceptable acid addition salts, hydrates of their pharmaceutically acceptable acid addition salts as well as the isomers and the tautomers thereof.

    摘要翻译： 本发明提供具有式（1）的化合物：其中R 1是氢，氟或甲氧基，R 1在芳族碳环的2,3,4或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐，其药学上可接受的酸加成盐的水合物及其异构体和互变异构体。

    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
    4.
    发明申请
    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors 有权
    咪唑化合物及其作为α-2肾上腺素能受体的用途

    公开(公告)号：US20070197793A1

    公开(公告)日：2007-08-23

    申请号：US11783079

    申请日：2007-04-05

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： C07D293/02

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    IMIDAZOLIC COMPOUNDS AND USE THEREOF AS ALPHA-2 ADRENERGIC RECEPTORS
    5.
    发明申请
    IMIDAZOLIC COMPOUNDS AND USE THEREOF AS ALPHA-2 ADRENERGIC RECEPTORS 有权
    咪唑类化合物及其作为ALPHA-2 ADRENERGIC受体的用途

    公开(公告)号：US20110021589A1

    公开(公告)日：2011-01-27

    申请号：US12785708

    申请日：2010-05-24

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： A61K31/4164 ,  A61P25/16 ,  A61P25/28

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
    6.
    发明授权
    Imidazolic compounds and use thereof as alpha-2 adrenergic receptors 有权
    咪唑化合物及其作为α-2肾上腺素能受体的用途

    公开(公告)号：US07776901B2

    公开(公告)日：2010-08-17

    申请号：US11783079

    申请日：2007-04-05

    申请人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    发明人： Bernard Vacher ,  Bernard Bonnaud ,  Marc Marien ,  Peter Pauwels

    IPC分类号： A61K31/4164

    CPC分类号： C07D233/56 ,  C07D233/64

    摘要： The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.

    摘要翻译： 本发明提供治疗需要这种治疗的受试者的记忆缺陷的方法，其中所述方法包括向受试者施用有效量的式（1）化合物：其中：R1是氢，氟或甲氧基， R1位于芳族碳环的2位，3位，4位或5位; R2是氢或甲基; R3是氢，甲基或乙基; 及其药学上可接受的酸加成盐以及其异构体和互变异构体。 记忆缺陷可能与东莨菪碱引起的记忆缺陷相关。

    Fluorinated imidazoline benzodioxane, preparation and therapeutic uses thereof
    8.
    发明授权
    Fluorinated imidazoline benzodioxane, preparation and therapeutic uses thereof 有权
    氟化咪唑啉苯并二氧杂环己烷，其制备和治疗用途

    公开(公告)号：US06610725B1

    公开(公告)日：2003-08-26

    申请号：US10019614

    申请日：2002-05-07

    申请人： Thierry Imbert ,  Patrice Mayer ,  Marc Marien ,  Peters Pauwels

    发明人： Thierry Imbert ,  Patrice Mayer ,  Marc Marien ,  Peters Pauwels

    IPC分类号： C07D40504

    CPC分类号： C07D405/04

    摘要： The present invention relates to novel fluorinated benzodioxane imidazoline derivatives, to their preparation and to their therapeutic applications. The invention is directed more particularly toward the compounds corresponding to the structure of general formula 1: in which: R represents a linear, branched or cyclized alkyl or alkenyl group containing 1 to 7 carbon atoms, or a benzyl group, and the fluorine atom can occupy position 5, 6, 7 or 8, in their racemic form and their dextrorotatory and levorotatory pure enantiomeric forms, and also the addition salts thereof.

    摘要翻译： 本发明涉及新的氟化苯并二恶烷咪唑啉衍生物及其制备方法及其治疗应用。本发明更具体地涉及对应于通式1结构的化合物：其中：R表示直链，支链或环烷基 或含有1至7个碳原子的烯基或苄基，并且氟原子可以占据其外消旋形式的第5,6,7或8位，以及它们的右旋和左旋纯对映体形式，以及它们的加成盐。