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    Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions
    2.
    发明申请
    Using Inhibitors of Histone Deacetylases for the Suppression Therapy of Inherited Disease Predisposing Conditions 失效
    使用组蛋白脱乙酰酶抑制剂抑制继发性疾病预防条件

    公开(公告)号：US20070037738A1

    公开(公告)日：2007-02-15

    申请号：US11275263

    申请日：2005-12-21

    申请人： Bernd Hentsch ,  Alexander Maurer ,  Sascha Hovelmann ,  Monika Raab ,  Elke Martin

    发明人： Bernd Hentsch ,  Alexander Maurer ,  Sascha Hovelmann ,  Monika Raab ,  Elke Martin

    IPC分类号： A61K38/12 ,  A61K31/19 ,  A61K31/20

    CPC分类号： A61K31/20 ,  A61K31/19 ,  A61K31/4436 ,  A61K31/505 ,  A61K2300/00

    摘要： Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, such compounds can be used for a suppressive therapeutic approach—the SUPPRESSION THERAPY—in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, a clinically used medicament can be manufactured for the SUPPRESSION THERAPY of such inherited predisposing conditions.

    摘要翻译： 化合物可用作具有组蛋白脱乙酰酶活性的酶的抑制剂，用于药物治疗易于使人发展疾病（例如但不限于癌症，炎性或代谢性疾病）的病症。 这种情况与关键基因的遗传遗传突变有关，这种突变使患有这种病症的人发展为疾病表型。 因此，这些化合物可以用于抑制性治疗方法 - 抑制疗法 - 以抑制或延缓遗传易感疾病的发作或进展。 此外，可以制造临床使用的药物用于这种遗传易感条件的抑制治疗。

    Using inhibitors of histone deacetylases for the suppression therapy of inherited disease predisposing conditions
    3.
    发明授权
    Using inhibitors of histone deacetylases for the suppression therapy of inherited disease predisposing conditions 失效
    使用组蛋白脱乙酰酶抑制剂进行遗传性疾病易感条件的抑制治疗

    公开(公告)号：US07892833B2

    公开(公告)日：2011-02-22

    申请号：US11275263

    申请日：2005-12-21

    申请人： Bernd Hentsch ,  Alexander B. Maurer ,  Sascha Hövelmann ,  Monika Raab ,  Elke Martin

    发明人： Bernd Hentsch ,  Alexander B. Maurer ,  Sascha Hövelmann ,  Monika Raab ,  Elke Martin

    IPC分类号： C12N15/01 ,  G01N33/53

    CPC分类号： A61K31/20 ,  A61K31/19 ,  A61K31/4436 ,  A61K31/505 ,  A61K2300/00

    摘要： Compounds can be used to act as inhibitors of enzymes having histone deacetylase activity for the medical therapy of conditions which predispose a person for the development of a disease, such as but not limited to cancer, inflammatory or metabolic diseases. Such conditions are linked to genetically inherited mutations of crucial genes which predispose a person with this condition to develop the disease phenotype. Thus, such compounds can be used for a suppressive therapeutic approach—the SUPPRESSION THERAPY—in order to inhibit or delay the onset or progression of the genetically predisposed disorder. Furthermore, a clinically used medicament can be manufactured for the SUPPRESSION THERAPY of such inherited predisposing conditions.

    摘要翻译： 化合物可用作具有组蛋白脱乙酰酶活性的酶的抑制剂，用于药物治疗易于使人发展疾病（例如但不限于癌症，炎性或代谢性疾病）的病症。 这种情况与关键基因的遗传遗传突变有关，这种突变使患有这种病症的人发展为疾病表型。 因此，这些化合物可以用于抑制性治疗方法 - 抑制疗法 - 以抑制或延缓遗传易感疾病的发作或进展。 此外，可以制造临床使用的药物用于这种遗传易感条件的抑制治疗。