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1.发明授权Antibodies specific for the melanoma-associated endogenous retrovirus (MERV) envelope glycoprotein 失效针对黑素瘤相关内源性逆转录病毒（MERV）包膜糖蛋白特异的抗体公开(公告)号：US08541553B2
公开(公告)日：2013-09-24
申请号：US12601780
申请日：2008-05-23
CPC分类号： C07K16/1036 , A61K2039/505 , C07K16/3053 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for the detection of cancer cells, especially of melanoma cells and methods for cancer diagnosis using said antibodies.
摘要翻译： 本发明提供用于分离和/或鉴定内源性逆转录病毒，优选黑素瘤相关内源性逆转录病毒的表位的抗体或其片段，以及产生所述抗体的杂交瘤细胞。 抗体特别适用于癌症的治疗和诊断。 此外，本申请包括用于检测癌细胞，特别是黑素瘤细胞的诊断试剂盒和使用所述抗体的癌症诊断方法。
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2.发明申请Melanoma-associated endogenous retrovirus (MERV) derived peptide sequences and their therapeutic/diagnostic use 审中-公开黑色素瘤相关内源性逆转录病毒（MERV）衍生的肽序列及其治疗/诊断用途公开(公告)号：US20090130129A1
公开(公告)日：2009-05-21
申请号：US11914098
申请日：2006-05-11
IPC分类号： A61K39/00 , C07K7/00 , C07K16/18 , G01N33/566 , G01N33/53 , G01N33/574
CPC分类号： A61K38/162 , A61K39/00 , C07K14/005 , C07K14/4748 , C07K16/1036 , C07K2317/34 , C12N2740/10022 , G01N33/5743 , G01N2333/15 , G01N2469/20
摘要： The present invention provides antigenic polypeptides derived from the melanoma-associated endogenous retrovirus (MERV). These antigens are useful compounds for the detection of cancerous cells and melanoma-diagnosis as well as melanoma-prognosis. Furthermore these antigenic polypeptides of the present invention form the basis for anti-cancer vaccines.
摘要翻译： 本发明提供衍生自黑素瘤相关内源性逆转录病毒（MERV）的抗原多肽。 这些抗原是检测癌细胞和黑素瘤诊断以及黑素瘤预后的有用化合物。 此外，本发明的这些抗原多肽形成抗癌疫苗的基础。
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3.发明申请Melanoma-Associated Endogenous Retrovirus (MERV) Derived Peptide Sequences And Their Therapeutic/Diagnostic Use 审中-公开黑色素瘤相关内源性逆转录病毒（MERV）衍生的肽序列及其治疗/诊断用途公开(公告)号：US20100285509A1
公开(公告)日：2010-11-11
申请号：US12768076
申请日：2010-04-27
CPC分类号： A61K38/162 , A61K39/00 , C07K14/005 , C07K14/4748 , C07K16/1036 , C07K2317/34 , C12N2740/10022 , G01N33/5743 , G01N2333/15 , G01N2469/20
摘要： The present invention provides antigenic polypeptides derived from the melanoma-associated endogenous retrovirus (MERV). These antigens are useful compounds for the detection of cancerous cells and melanoma-diagnosis as well as melanoma-prognosis. Furthermore these antigenic polypeptides of the present invention form the basis for anti-cancer vaccines.
摘要翻译： 本发明提供衍生自黑素瘤相关内源性逆转录病毒（MERV）的抗原多肽。 这些抗原是检测癌细胞和黑素瘤诊断以及黑素瘤预后的有用化合物。 此外，本发明的这些抗原多肽形成抗癌疫苗的基础。
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公开(公告)号：US20100136518A1
公开(公告)日：2010-06-03
申请号：US12601780
申请日：2008-05-23
IPC分类号： C12Q1/70 , C07K16/00 , C12N5/16 , C12N7/02 , G01N33/574
CPC分类号： C07K16/1036 , A61K2039/505 , C07K16/3053 , C07K2317/34 , C07K2317/73 , C07K2317/732
摘要： The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for the detection of cancer cells, especially of melanoma cells and methods for cancer diagnosis using said antibodies.
摘要翻译： 本发明提供用于分离和/或鉴定内源性逆转录病毒，优选黑素瘤相关内源性逆转录病毒的表位的抗体或其片段，以及产生所述抗体的杂交瘤细胞。 抗体特别适用于癌症的治疗和诊断。 此外，本申请包括用于检测癌细胞，特别是黑素瘤细胞的诊断试剂盒和使用所述抗体的癌症诊断方法。
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公开(公告)号：US06783869B2
公开(公告)日：2004-08-31
申请号：US10290060
申请日：2002-11-07
申请人： Johannes Humer , Herbert Kirsch , Markus Manner , Robert Mergen
发明人： Johannes Humer , Herbert Kirsch , Markus Manner , Robert Mergen
IPC分类号： B32B1504
CPC分类号： C22C21/10 , C22C21/02 , F16C33/121 , Y10S384/912 , Y10T428/12736 , Y10T428/1275
摘要： The invention relates to an aluminium alloy for an anti-friction element containing respectively, as a % by weight, 4.2% to 4.8% Zn, 3.0% to 7.0% Si, 0.8% to 1.2% Cu, 0.7% to 1.3% Pb, 0.12% to 0.18% Mg, 0% to 0.3% Mn and 0% to 0.2% Ni. Also incorporated, based on % by weight, are 0.05% to 0.1% Zr, 0% to 0.05% Ti, 0% to 0.4% Fe, 0% to 0.2% Sn. The rest is formed by Al with the usual incidental impurities depending on the melt.
摘要翻译： 本发明涉及一种抗摩擦元件的铝合金，其分别含有以重量％计含有4.2％至4.8％的Zn，3.0％至7.0％的Si，0.8％至1.2％的Cu，0.7％至1.3％的Pb， 0.12％〜0.18％Mg，0％〜0.3％Mn，0％〜0.2％Ni。 基于重量％还含有0.05％至0.1％的Zr，0％至0.05％的Ti，0％至0.4％的Fe，0％至0.2％的Sn。 其余由Al形成，具有取决于熔体的常见杂质。
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