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公开(公告)号:US06793918B2
公开(公告)日:2004-09-21
申请号:US09985159
申请日:2001-11-01
申请人: Berndt Enholm , Didier Branellec , Seppo Ylae-Herttuala , Ralf Pettersson , Erika Bergsten , Ulf Eriksson , Kari Alitalo , Aude Le Roux
发明人: Berndt Enholm , Didier Branellec , Seppo Ylae-Herttuala , Ralf Pettersson , Erika Bergsten , Ulf Eriksson , Kari Alitalo , Aude Le Roux
IPC分类号: A61K4800
CPC分类号: C07K14/515 , A61K31/70 , A61K38/1866 , A61K48/00 , A61K48/005 , C07K14/52 , C12N7/00 , C12N15/86 , C12N2710/10343 , C12N2840/203
摘要: Angiogenesis is stimulated by introducing two replication-deficient adenovirus vectors to the endothelial cells or proximate to the endothelial cells of an organism. The first vector encodes VEGF-B167 or a fragment or conservative substitution thereof, the second vector encodes VEGF-A or VEGF-C, or fragments or conservative substitutions thereof.
摘要翻译: 通过将两个复制缺陷型腺病毒载体引入内皮细胞或接近生物体的内皮细胞来刺激血管发生。 第一载体编码VEGF-B167或其片段或保守取代,第二载体编码VEGF-A或VEGF-C,或其片段或保守取代。