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公开(公告)号：US5882865A
公开(公告)日：1999-03-16
申请号：US781201
申请日：1997-01-10
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
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公开(公告)号：US5888735A
公开(公告)日：1999-03-30
申请号：US781200
申请日：1997-01-10
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
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公开(公告)号：US06511818B2
公开(公告)日：2003-01-28
申请号：US09828906
申请日：2001-04-10
IPC分类号： C12Q102
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , G01N33/5008 , G01N33/5011 , G01N2510/00 , C12Q2563/173
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
摘要翻译： 检查点基因缺陷的人细胞可用于筛选潜在的抗肿瘤剂。 筛选潜在的治疗剂在检查点基因缺陷型人细胞中引起DNA积累或细胞死亡的能力。
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公开(公告)号：US07148009B2
公开(公告)日：2006-12-12
申请号：US10320639
申请日：2002-12-17
IPC分类号： C12Q1/68
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , G01N33/5008 , G01N33/5011 , G01N2510/00 , C12Q2563/173
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
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公开(公告)号：US5879889A
公开(公告)日：1999-03-09
申请号：US781203
申请日：1997-01-10
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
摘要翻译： 检查点基因缺陷的人细胞可用于筛选潜在的抗肿瘤剂。 筛选潜在的治疗剂在检查点基因缺陷型人细胞中引起DNA积累或细胞死亡的能力。
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公开(公告)号：US06214616B1
公开(公告)日：2001-04-10
申请号：US09298822
申请日：1999-04-26
IPC分类号： C12N508
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , C12Q2600/136 , G01N33/5008 , G01N33/5011 , G01N2510/00 , C12Q2563/173
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
摘要翻译： 检查点基因缺陷的人细胞可用于筛选潜在的抗肿瘤剂。 筛选潜在的治疗剂在检查点基因缺陷型人细胞中引起DNA积累或细胞死亡的能力。
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公开(公告)号：US5897999A
公开(公告)日：1999-04-27
申请号：US620340
申请日：1996-03-22
CPC分类号： G01N33/5044 , C12Q1/6841 , C12Q1/6886 , G01N33/5008 , G01N33/5011 , C12Q2600/136 , G01N2510/00
摘要： Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
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公开(公告)号：US20140094384A1
公开(公告)日：2014-04-03
申请号：US14088932
申请日：2013-11-25
申请人： David SOLOMON , Jung-Sik Kim , Todd Waldman
发明人： David SOLOMON , Jung-Sik Kim , Todd Waldman
IPC分类号： C07K14/47 , C12Q1/68 , C12N15/85 , G01N33/574 , G01N33/50
CPC分类号： C07K14/47 , C12N15/85 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/574 , G01N33/57407 , G01N33/5743 , G01N33/57484 , G01N2800/52
摘要： Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.
摘要翻译： 与基质抗原2（STAG2）相关的组合物和方法及其在多种人类癌症中的作用，包括核酸，多肽，载体，细胞和细胞系。
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公开(公告)号：US20130029865A1
公开(公告)日：2013-01-31
申请号：US13547966
申请日：2012-07-12
申请人： David SOLOMON , Jung-Sik Kim , Todd Waldman
发明人： David SOLOMON , Jung-Sik Kim , Todd Waldman
CPC分类号： C07K14/47 , C12N15/85 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/574 , G01N33/57407 , G01N33/5743 , G01N33/57484 , G01N2800/52
摘要： Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.
摘要翻译： 与基质抗原2（STAG2）相关的组合物和方法及其在多种人类癌症中的作用，包括核酸，多肽，载体，细胞和细胞系。
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10.发明申请Isogenic beta-catenin cell lines, and methods of making and using same 审中-公开异源β-连环蛋白细胞系，以及制备和使用它们的方法公开(公告)号：US20050208652A1
公开(公告)日：2005-09-22
申请号：US11104063
申请日：2005-04-11
申请人： Todd Waldman
发明人： Todd Waldman
CPC分类号： G01N33/5011 , C07K14/4702 , C12N5/0693 , C12N2510/00 , G01N2500/10
摘要： A set of isogenic cell lines, which includes a first population of cells that express only a wild type β-catenin polypeptide and at least a second population of cells that express only an activated β-catenin polypeptide, is provided. A set of isogenic cells, including a first population of cells that are null for β-catenin expression, and at least a second population of cells that express a wild type β-catenin polypeptide that functions as an activated β-catenin polypeptide in the cells, also is provided. In addition, a recombinant nucleic acid molecule, which includes at least a first linear polynucleotide that is flanked at each end by nucleotide sequences of a β-catenin gene is provided, as is a method of using the recombinant nucleic acid molecule to produce a set of isogenic cell lines as defined above. Also provide is a method of using the set of isogenic cell lines to identify a therapeutic agent that allows selective killing of cells expressing an activated β-catenin polypeptide, but not cells expressing a wild type β-catenin polypeptide is provided.
摘要翻译： 提供了一组等基因细胞系，其包括仅表达野生型β-连环蛋白多肽的细胞的第一群和至少仅表达活化的β-连环蛋白多肽的第二细胞群。 一组等位基因细胞，包括对于β-连环蛋白表达无效的第一个细胞群，以及至少第二个表达野生型β-连环蛋白多肽的第二细胞群，其在细胞中用作活化的β-连环蛋白多肽 ，也被提供。 此外，提供了重组核酸分子，其包括至少第一线性多核苷酸，其每端末端具有β-连环蛋白基因的核苷酸序列，正如使用重组核酸分子产生组的方法一样 的等位基因细胞系。 还提供使用该组等基因细胞系鉴定允许选择性杀死表达活化的β-连环蛋白多肽的细胞但不表达野生型β-连环蛋白多肽的细胞的治疗剂的方法。
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