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公开(公告)号：US09181544B2
公开(公告)日：2015-11-10
申请号：US13985023
申请日：2012-02-13
IPC分类号： C12N15/11 , C07H19/00 , C12N15/113
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/11 , C12N15/111 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2320/53 , C12N2330/51 , C12N2750/14143
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
摘要翻译： 本发明涉及针对亨廷顿氏病核酸序列的RNA干扰（RNAi）分子，以及使用这些RNAi分子治疗亨廷顿氏病的方法。
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2.发明授权RNA interference suppresion of neurodegenerative diseases and methods of use thereof 有权RNA干扰抑制神经变性疾病及其使用方法公开(公告)号：US08524879B2
公开(公告)日：2013-09-03
申请号：US12774019
申请日：2010-05-05
申请人： Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan L. Boudreau , Scott Harper
发明人： Beverly L. Davidson , Haibin Xia , Qinwen Mao , Henry Paulson , Ryan L. Boudreau , Scott Harper
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
摘要： The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
摘要翻译： 本发明涉及针对编码亨廷汀或大麻素-1的核酸序列的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。
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公开(公告)号：US20140142288A1
公开(公告)日：2014-05-22
申请号：US13985023
申请日：2012-02-13
IPC分类号： C12N15/11
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/11 , C12N15/111 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2320/53 , C12N2330/51 , C12N2750/14143
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a Huntington's disease nucleic acid sequence, and methods of using these RNAi molecules to treat Huntington's disease.
摘要翻译： 本发明涉及针对亨廷顿氏病核酸序列的RNA干扰（RNAi）分子，以及使用这些RNAi分子治疗亨廷顿氏病的方法。
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公开(公告)号：US08487088B2
公开(公告)日：2013-07-16
申请号：US12977812
申请日：2010-12-23
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2310/531 , C12N2320/30 , C12N2320/34 , C12N2750/14143
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
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5.发明申请RNA INTERFERENCE SUPPRESSION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOF 有权RNA干扰抑制神经损伤性疾病及其使用方法公开(公告)号：US20110244562A1
公开(公告)日：2011-10-06
申请号：US12977812
申请日：2010-12-23
CPC分类号： C12N15/113 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/141 , C12N2310/53 , C12N2310/531 , C12N2320/30 , C12N2320/34 , C12N2750/14143
摘要： The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence that encodes poly-glutamine repeat diseases, and methods of using these RNAi molecules.
摘要翻译： 本发明涉及针对编码多谷氨酰胺重复疾病的核酸序列的RNA干扰（RNAi）分子，以及使用这些RNAi分子的方法。
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