-
1.发明授权公开(公告)号：US09145462B2
公开(公告)日：2015-09-29
申请号：US13172759
申请日：2011-06-29
申请人： Bin Liu , James D. Marks , Xiaodong Zhu , Scott Bidlingmaier
发明人： Bin Liu , James D. Marks , Xiaodong Zhu , Scott Bidlingmaier
IPC分类号： A61K39/395 , C07K16/28 , C07K16/30 , C12N5/095 , G01N33/574
CPC分类号： C07K16/18 , A61K47/6843 , A61K51/1045 , C07K16/2896 , C07K16/3053 , C07K2317/21 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C12N5/0695 , G01N33/57407
摘要： The present disclosure is generally related to antibodies that bind specifically to glioblastoma multiforme (GBM) cells. In particular, the present disclosure provides compositions comprising human single chain or full-length antibodies that bind tumor cells. Additionally the present disclosure provides methods of using the anti-GBM antibodies.
摘要翻译： 本公开通常涉及特异性结合多形性胶质母细胞瘤（GBM）细胞的抗体。 特别地，本公开提供了包含结合肿瘤细胞的人单链或全长抗体的组合物。 另外，本公开提供了使用抗GBM抗体的方法。
-
2.发明授权Internalizing human monoclonal antibodies targeting prostate cancer cells in situ 有权内源化靶向前列腺癌细胞的人单克隆抗体原位公开(公告)号：US08865873B2
公开(公告)日：2014-10-21
申请号：US12724282
申请日：2010-03-15
申请人： Bin Liu , James D. Marks
发明人： Bin Liu , James D. Marks
CPC分类号： C07K16/3069 , A61K51/1072 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/77 , G01N33/5044 , G01N33/57434 , G01N33/6845 , G01N33/6854
摘要： This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.
摘要翻译： 本发明提供允许使用激光捕获显微切割原位选择针对细胞（例如肿瘤细胞）的抗体的方法。 通过将抗体选择限于内化表位的结合物，产生一组靶向临床表现的前列腺癌抗原的噬菌体抗体。
-
公开(公告)号：US07582736B2
公开(公告)日：2009-09-01
申请号：US11972130
申请日：2008-01-10
申请人： Bin Liu , James D. Marks
发明人： Bin Liu , James D. Marks
IPC分类号： C12P21/08
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/622 , C07K2317/73 , C07K2317/77
摘要： This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.
摘要翻译： 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。
-
公开(公告)号：US07335744B2
公开(公告)日：2008-02-26
申请号：US11021438
申请日：2004-12-21
申请人： Bin Liu , James D. Marks
发明人： Bin Liu , James D. Marks
IPC分类号： C12P21/08
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/622 , C07K2317/73 , C07K2317/77
摘要： This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.
摘要翻译： 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身可用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。
-
公开(公告)号：US20090010841A1
公开(公告)日：2009-01-08
申请号：US11972130
申请日：2008-01-10
申请人： Bin Liu , James D. Marks
发明人： Bin Liu , James D. Marks
IPC分类号： C07K16/30 , C07K16/46 , A61K39/395 , A61K51/10 , C12N15/13 , C12N5/10 , G01N33/574 , C12N5/06 , A61P35/00
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/622 , C07K2317/73 , C07K2317/77
摘要： This invention provides novel prostate cancer specific internalizing human antibodies. The antibodies are useful by themselves to prevent growth and/or proliferation of prostate cancer cells. The antibodies can also be formulated as chimeric molecules to direct an effector (e.g. a cytotoxin, an imaging reagent, a drug, etc.) to a prostate tumor site.
摘要翻译： 本发明提供了新型前列腺癌特异性内化人抗体。 抗体本身有用于预防前列腺癌细胞的生长和/或增殖。 抗体还可以配制成嵌合分子以将效应物（例如细胞毒素，成像试剂，药物等）引导至前列腺肿瘤部位。
-
-
-
-
公开(公告)号：US10753941B2
公开(公告)日：2020-08-25
申请号：US14342074
申请日：2012-09-03
申请人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
发明人： Benzhong Tang , Wei Qin , Jianzhao Liu , Sijie Chen , Tsz Kin Kwok , Bin Liu , Kai Li , Dan Ding , Haibin Shi , Jun Long Geng , Jingzhi Sun , Anjun Qin , Qiuli Zhao
摘要： The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.
-
公开(公告)号：US20190024246A1
公开(公告)日：2019-01-24
申请号：US14692886
申请日：2015-04-22
申请人： Peidong Yang , Chong Liu , Jinyao Tang , Hao Ming Chen , Bin Liu
发明人： Peidong Yang , Chong Liu , Jinyao Tang , Hao Ming Chen , Bin Liu
摘要： This disclosure provides systems, methods, and apparatus related to solar water splitting. In one aspect, a structure includes a plurality of first nanowires, the plurality of first nanowires comprising an n-type semiconductor or a p-type semiconductor. The structure further includes a second nanowire, the second nanowire comprising the n-type semiconductor or the p-type semiconductor, the second nanowire being a different composition than the plurality of first nanowires. The second nanowire includes a first region and a second region, with the first region having a conductive layer disposed thereon, and each of the plurality of first nanowires being disposed on the conductive layer.
-
-
-
-
-
-
-
-
-
搜索结果
190 条记录 (耗时 0.031 秒)
