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    VACCINE PREVENTING AND/OR TREATING AUTOIMMUNE DISEASES
    1.
    发明申请
    VACCINE PREVENTING AND/OR TREATING AUTOIMMUNE DISEASES 审中-公开
    疫苗预防和/或治疗自身免疫性疾病

    公开(公告)号：US20100143401A1

    公开(公告)日：2010-06-10

    申请号：US12532643

    申请日：2008-03-19

    申请人： Bin Wang ,  Huali Jin ,  Youmin Kang ,  Wenjuan Zhang ,  Yang Yu ,  Jinyao Li

    发明人： Bin Wang ,  Huali Jin ,  Youmin Kang ,  Wenjuan Zhang ,  Yang Yu ,  Jinyao Li

    IPC分类号： A61K39/00 ,  A61P37/04 ,  A61P3/10

    CPC分类号： A61K39/0008 ,  A01K2267/0325 ,  A61K2039/53 ,  A61K2039/545

    摘要： The present invention discloses a vaccine preventing and/or treating autoimmune diseases. Its active component is: the mixture consisting of a protein antigen causing an autoimmune disease or the epitope polypeptides thereof, and the recombinant eukaryotic vector with the coding genes of an autoantigen or the epitope polypeptides thereof inserted into multiple cloning sites. The autoantigen is insulin, glutamic acid decarboxylase or heat shock protein, myelin oligodendrocyte glycoprotein, two myelin antigens, zona pellucida 3, myoglobulin, type II collagen, thyroglobulin, cell membrane surface antigen, type II colloid antigen, acetylcholine receptor, thyrocyte cell surface antigen, salivary gland duct antigen, thyroglobulin, superantigen, or interphotoreceptor retinoid binding protein. The vaccine can inhibit the proliferation of T cells of immune animals and humans, induce the occurrence of immune suppression, as well as prevent and/or treat autoimmune diseases effectively.

    摘要翻译： 本发明公开了一种预防和/或治疗自身免疫疾病的疫苗。 其活性组分是：由引起自身免疫疾病的蛋白质抗原或其表位多肽组成的混合物和具有插入到多个克隆位点中的自身抗原或其表位多肽的编码基因的重组真核载体。 自身抗原是胰岛素，谷氨酸脱羧酶或热休克蛋白，髓鞘少突胶质细胞糖蛋白，两种髓鞘抗原，透明带3，肌球蛋白，II型胶原，甲状腺球蛋白，细胞膜表面抗原，II型胶体抗原，乙酰胆碱受体，甲状腺细胞表面抗原 ，唾液腺导管抗原，甲状腺球蛋白，超抗原或视网膜受体类视黄醇结合蛋白。 疫苗可以抑制免疫动物和人类的T细胞的增殖，诱导免疫抑制的发生，以及有效地预防和/或治疗自身免疫性疾病。

    T cell immune response inhibitor
    2.
    发明申请
    T cell immune response inhibitor 审中-公开
    T细胞免疫应答抑制剂

    公开(公告)号：US20070184037A1

    公开(公告)日：2007-08-09

    申请号：US10590040

    申请日：2005-01-31

    申请人： Bin Wang ,  Qingling Yu ,  Huali Jin ,  Youmin Kang

    发明人： Bin Wang ,  Qingling Yu ,  Huali Jin ,  Youmin Kang

    IPC分类号： A61K48/00 ,  C12N5/08 ,  C12N5/10

    CPC分类号： A61K39/00 ,  A61K48/00 ,  A61K2039/57

    摘要： The present invention discloses a T-cell immune response inhibitor. The T-cell immune response inhibitor supplied in the present invention comprises a targeted pathogen nucleic acid vaccine and said nucleic acid vaccine's expression protein antigen; or it comprises a targeted pathogen nucleic acid vaccine and said nucleic acid vaccine expression protein antigen's active polypeptide; or it comprises the inactivated pathogen and targeted pathogen nucleic acid vaccine. The T-cell immune response inhibitor in the present invention is able to stimulate the organism to produce the normal specific antibody immune response and to suppress a specific cell's immune response, in particular the Th1 immune response, thus it may be effectively applied to treatment of autoimmune diseases, organ transplants, allergies and control of T-cell levels.

    摘要翻译： 本发明公开了一种T细胞免疫应答抑制剂。 本发明提供的T细胞免疫应答抑制剂包含靶向病原体核酸疫苗和所述核酸疫苗的表达蛋白质抗原; 或者其包含靶向病原体核酸疫苗和所述核酸疫苗表达蛋白抗原的活性多肽; 或者其包含灭活的病原体和靶向的病原体核酸疫苗。 本发明中的T细胞免疫应答抑制剂能够刺激生物体产生正常的特异性抗体免疫应答并抑制特定细胞的免疫应答，特别是Th1免疫应答，因此可有效地应用于治疗 自身免疫疾病，器官移植，过敏和T细胞水平的控制。

    Allergy inhibitor compositions and kits and methods of using the same
    7.
    发明申请
    Allergy inhibitor compositions and kits and methods of using the same 有权
    过敏抑制剂组合物及其使用方法

    公开(公告)号：US20070166335A1

    公开(公告)日：2007-07-19

    申请号：US11644435

    申请日：2006-12-22

    申请人： Bin Wang ,  Huali Jin ,  Youmin Kang ,  Hsien-Jue Chu ,  Terry Kaleung Ng

    发明人： Bin Wang ,  Huali Jin ,  Youmin Kang ,  Hsien-Jue Chu ,  Terry Kaleung Ng

    IPC分类号： A61K39/35 ,  A61K48/00

    CPC分类号： A61K39/35 ,  A61K39/0003 ,  A61K39/0005 ,  A61K39/0008 ,  A61K2039/53 ,  A61K2039/57

    摘要： Compositions and kits for inhibiting an allergic response against an allergenic protein are disclosed. The compositions comprise a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein; and an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein. The kits comprise a first container which comprises a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein and a second container which comprises an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein. Compositions and kits for inhibiting an allergic response against an flea allergenic protein; a feline allergenic protein; a canine allergenic protein; a dust mite allergenic protein; a peanut allergenic protein; a Japanese cedar allergenic protein; and a blomia tropicalis allergenic protein are disclosed. Methods if using such compositions and kits are also disclosed.

    摘要翻译： 公开了抑制对变应原性蛋白质的过敏反应的组合物和试剂盒。 所述组合物包含含有编码过敏原蛋白或包含所述变应原蛋白的抗原表位的多肽的核苷酸序列的真核细胞表达载体; 以及包含过敏原蛋白的抗原表位的变应原蛋白或多肽。 所述试剂盒包括第一容器，其包含含有编码过敏原蛋白的核苷酸序列的真核细胞表达载体或包含过敏原蛋白的抗原表位的多肽，以及第二容器，其包含过敏原蛋白或包含抗原表位的多肽 说过敏性蛋白质。 用于抑制针对跳蚤过敏原蛋白质的过敏反应的组合物和试剂盒; 猫过敏原蛋白; 犬过敏蛋白; 尘螨过敏原蛋白; 花生过敏蛋白; 日本雪松过敏蛋白; 并且公开了热带炎热带炎性过敏蛋白。 还公开了使用这些组合物和试剂盒的方法。

    Allergy inhibitor compositions and kits and methods of using the same
    9.
    发明授权
    Allergy inhibitor compositions and kits and methods of using the same 有权
    过敏抑制剂组合物及其使用方法

    公开(公告)号：US08349333B2

    公开(公告)日：2013-01-08

    申请号：US11644435

    申请日：2006-12-22

    申请人： Bin Wang ,  Huali Jin ,  Youmin Kang ,  Hsien-Jue Chu ,  Terry Kaleung Ng

    发明人： Bin Wang ,  Huali Jin ,  Youmin Kang ,  Hsien-Jue Chu ,  Terry Kaleung Ng

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00 ,  C12P15/00 ,  C12P21/06

    CPC分类号： A61K39/35 ,  A61K39/0003 ,  A61K39/0005 ,  A61K39/0008 ,  A61K2039/53 ,  A61K2039/57

    摘要： Compositions and kits for inhibiting an allergic response against an allergenic protein are disclosed. The compositions comprise a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein; and an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein. The kits comprise a first container which comprises a eukaryotic cell expression vector containing nucleotide sequences encoding an allergenic protein or a polypeptide that comprises an antigenic epitope of the allergenic protein and a second container which comprises an allergenic protein or a polypeptide that comprises an antigenic epitope of said allergenic protein. Compositions and kits for inhibiting an allergic response against an flea allergenic protein; a feline allergenic protein; a canine allergenic protein; a dust mite allergenic protein; a peanut allergenic protein; a Japanese cedar allergenic protein; and a blomia tropicalis allergenic protein are disclosed. Methods if using such compositions and kits are also disclosed.

    摘要翻译： 公开了抑制对变应原性蛋白质的过敏反应的组合物和试剂盒。 所述组合物包含含有编码过敏原蛋白或包含所述变应原蛋白的抗原表位的多肽的核苷酸序列的真核细胞表达载体; 以及包含过敏原蛋白的抗原表位的变应原蛋白或多肽。 所述试剂盒包括第一容器，其包含含有编码过敏原蛋白的核苷酸序列的真核细胞表达载体或包含过敏原蛋白的抗原表位的多肽，以及第二容器，其包含过敏原蛋白或包含抗原表位的多肽 说过敏性蛋白质。 用于抑制针对跳蚤过敏原蛋白质的过敏反应的组合物和试剂盒; 猫过敏原蛋白; 犬过敏蛋白; 尘螨过敏原蛋白; 花生过敏蛋白; 日本雪松过敏蛋白; 并且公开了热带炎热带炎性过敏蛋白。 还公开了使用这些组合物和试剂盒的方法。

    VACCINES FOR PREVENTING AND TREATING ALZHEIMER'S DISEASE
    10.
    发明申请
    VACCINES FOR PREVENTING AND TREATING ALZHEIMER'S DISEASE 审中-公开
    预防和治疗阿尔茨海默病的疫苗

    公开(公告)号：US20140227304A1

    公开(公告)日：2014-08-14

    申请号：US14233836

    申请日：2012-07-27

    申请人： Bin Wang ,  Yang Yu ,  Xianzhu Zhu ,  Shuang Wang

    发明人： Bin Wang ,  Yang Yu ,  Xianzhu Zhu ,  Shuang Wang

    IPC分类号： C07K14/47

    CPC分类号： C07K14/4711 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/0005 ,  A61K45/06 ,  C07K16/18

    摘要： Disclosed herein are vaccines comprising an amyloid beta antigen and a nucleic acid encoding the amyloid beta antigen, or a variant thereof. T cell proliferation can be inhibited and iTreg cells can be stimulated in the subject administered the vaccine. Further provided are methods for treating Alzheimer's Disease, methods for reducing or slowing the rate of formation of amyloid beta plaques, methods for treating encephalitis, and methods for of reducing brain swelling. The methods can comprise administering the vaccine to a subject in need thereof.

    摘要翻译： 本文公开了包含淀粉样蛋白β抗原和编码淀粉样蛋白β抗原的核酸或其变体的疫苗。 可以抑制T细胞增殖并且在施用疫苗的受试者中刺激iTreg细胞。 还提供了治疗阿尔茨海默病的方法，降低或减缓淀粉样蛋白β斑块形成速率的方法，治疗脑炎的方法和减轻脑肿胀的方法。 所述方法可以包括向有需要的受试者施用疫苗。