公开(公告)号：US08338372B2

公开(公告)日：2012-12-25

申请号：US12680650

申请日：2008-08-25

申请人： Bingxiang Xu ,  Haisong Xie ,  Huan Yu ,  Wei Mao ,  Weidong Ye

发明人： Bingxiang Xu ,  Haisong Xie ,  Huan Yu ,  Wei Mao ,  Weidong Ye

IPC分类号： A61K38/14 ,  C07K9/00 ,  C07K1/22 ,  A61P31/04

CPC分类号： C07K9/008 ,  A61K38/14 ,  C12P19/46 ,  C12P19/60

摘要： The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) preparing a concentrated vancomycin solution containing the deshydroxy vancomycin by fermentations of Amycolatopsis Orientalis with Deposit No. CGMCCNO.1183; (2) separating and purifing the concentrated vancomycin solution to obtain a refined filtrate of vancomycin hydrochloride containing the deshydroxy vancomycin by column chromatography; and (3) further separating and purifing the refined filtrate to obtain the deshydroxy vancomycin by chromatography. Wherein, separation and purification is processed by column chromatography in a gel chromatography column containing a salt-water mobile phase, separation and purification is processed by chromatography in a macroporous adsorption resin chromatography column containing a buffer-methanol mobile phase.

摘要翻译： 本发明提供了一种脱羟基万古霉素化合物，其制备方法和包含药学有效量的脱羟万古霉素的药物组合物，以及所述组合物在制备用于治疗易感细菌感染的药物中的用途。 该方法包括以下步骤：（1）通过发酵具有沉积物号CGMCCNO.1183的Amycolatopsis Orientalis的发酵制备含有脱羟万古霉素的浓缩万古霉素溶液; （2）分离纯化浓缩的万古霉素溶液，通过柱色谱法得到含有脱羟万古霉素的万古霉素盐酸盐精制滤液; 和（3）进一步分离和纯化精制滤液，通过色谱法获得脱羟万古霉素。 其中分离纯化在含有盐水流动相的凝胶色谱柱中通过柱色谱法处理，分离和纯化在含有缓冲液 - 甲醇流动相的大孔吸附树脂色谱柱中通过色谱法处理。

公开(公告)号：US20100222252A1

公开(公告)日：2010-09-02

申请号：US12680650

申请日：2008-08-25

申请人： Bingxiang Xu ,  Haisong Xie ,  Huan Yu ,  Wei Mao ,  Weidong Ye

发明人： Bingxiang Xu ,  Haisong Xie ,  Huan Yu ,  Wei Mao ,  Weidong Ye

IPC分类号： A61K38/14 ,  C07K9/00 ,  C07K1/22 ,  A61P31/04

CPC分类号： C07K9/008 ,  A61K38/14 ,  C12P19/46 ,  C12P19/60

摘要： The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) preparing a concentrated vancomycin solution containing the deshydroxy vancomycin by fermentations of Amycolatopsis Orientalis with Deposit No. CGMCCNO.1183; (2) separating and purifing the concentrated vancomycin solution to obtain a refined filtrate of vancomycin hydrochloride containing the deshydroxy vancomycin by column chromatography; and (3) further separating and purifing the refined filtrate to obtain the deshydroxy vancomycin by chromatography. Wherein, separation and purification is processed by column chromatography in a gel chromatography column containing a salt-water mobile phase, separation and purification is processed by chromatography in a macroporous adsorption resin chromatography column containing a buffer-methanol mobile phase.

摘要翻译： 本发明提供了一种脱羟基万古霉素化合物，其制备方法和包含药学有效量的脱羟万古霉素的药物组合物，以及所述组合物在制备用于治疗易感细菌感染的药物中的用途。 该方法包括以下步骤：（1）通过发酵具有沉积物号CGMCCNO.1183的Amycolatopsis Orientalis的发酵制备含有脱羟万古霉素的浓缩万古霉素溶液; （2）分离纯化浓缩的万古霉素溶液，通过柱色谱法得到含有脱羟万古霉素的万古霉素盐酸盐精制滤液; 和（3）进一步分离和纯化精制滤液，通过色谱法获得脱羟万古霉素。 其中分离纯化在含有盐水流动相的凝胶色谱柱中通过柱色谱法处理，分离和纯化在含有缓冲液 - 甲醇流动相的大孔吸附树脂色谱柱中通过色谱法处理。

公开(公告)号：US20120170448A1

公开(公告)日：2012-07-05

申请号：US13258201

申请日：2010-05-10

申请人： Wei Mao ,  Tong Leng ,  Zhining Ye

发明人： Wei Mao ,  Tong Leng ,  Zhining Ye

IPC分类号： H04L12/24

CPC分类号： H04L12/403 ,  H04L12/2858 ,  H04L12/4641 ,  H04L41/0663 ,  H04L63/08

摘要： A method and network system for implementing user port locating in multi-machine backup scenario of broadband remote access server (BRAS) are disclosed. The method comprises: configuring master port in each backup group as user access port and synchronizing information of taking the maser port as user access port to the backup port in the backup group; a remote authentication dial in user service (RADIUS) server configuring access port information, which is set as the master port in the backup group, for the user; processing master-backup switch if the master port is abnormal and the user accessing the line from the corresponding backup port; the BRAS corresponding to the backup port encapsulating the authentication message including the access line information about digital subscriber line access multiplexer of the user access and taking the maser port as the user access port, and sending the authentication message to the RADIUS server.

摘要翻译： 公开了一种用于实现宽带远程访问服务器（BRAS）多机备份场景中用户端口定位的方法和网络系统。 该方法包括：将每个备份组中的主端口作为用户接入端口，并将采用主用户端口的用户接入端口的同步信息备份到备份组中的备份端口; 在用户服务（RADIUS）服务器中配置远程认证拨号，用于为用户配置作为备份组中的主端口的访问端口信息; 如果主端口异常，用户从相应的备份端口接入线路，则处理主备交换机; 所述BRAS对应于所述备份端口，封装所述认证消息，所述认证消息包括所述用户接入用户线路接入复用器的接入线信息，并且以所述主机端口为所述用户接入端口，并将所述认证消息发送给所述RADIUS服务器。

公开(公告)号：US20110118979A1

公开(公告)日：2011-05-19

申请号：US12621745

申请日：2009-11-19

申请人： Wei Mao ,  Lukas Marti

发明人： Wei Mao ,  Lukas Marti

IPC分类号： G01C21/26

CPC分类号： G01C21/005 ,  G01C21/165

摘要： A method of operating an automotive location system may include providing a timely warning if the system cannot satisfy predetermined performance criteria. An example method may include ascertaining a satellite-based position estimation ascertaining a dead reckoning position estimation, determining a location estimation by combining the satellite position estimation and the dead reckoning position estimation, determining a map-matching position, and determining an integrity of the location estimation by comparing a test statistic calculated by evaluating the map-matching position and the location estimation with a decision threshold based upon a predetermined location estimation accuracy specification. If the test statistic is less than the decision threshold, the system may provide the location estimation. If the test statistic is greater than the decision threshold, the system may provide an indication that the integrity of the location estimation does not satisfy the predetermined location estimation accuracy specification.

摘要翻译： 如果系统不能满足预定的性能标准，那么操作汽车定位系统的方法可以包括提供及时的警告。 示例性方法可以包括确定确定航位推算位置估计的基于卫星的位置估计，通过组合卫星位置估计和航位推算位置估计来确定位置估计，确定地图匹配位置以及确定位置的完整性 通过基于预定的位置估计精度指标，通过将通过评估地图匹配位置和位置估计计算出的测试统计量与判定阈值进行比较来估计。 如果测试统计量小于决策阈值，则系统可以提供位置估计。 如果测试统计量大于判定阈值，则系统可以提供位置估计的完整性不满足预定位置估计精度规范的指示。

公开(公告)号：US20210377116A1

公开(公告)日：2021-12-02

申请号：US17404309

申请日：2021-08-17

申请人： Shu-ping Yeh ,  Jaemin Han ,  Wei Mao ,  Jingwen Bai ,  Murali Narasimha

发明人： Shu-ping Yeh ,  Jaemin Han ,  Wei Mao ,  Jingwen Bai ,  Murali Narasimha

IPC分类号： H04L12/24 ,  H04W24/10 ,  H04L12/26 ,  H04L1/00

摘要： Embodiments of a virtualized radio-access network (RAN) node configured to implement functions including an O-RAN Distributed Unit (DU), an O-RAN Radio Unit (RU), an O-RAN Central Unit-Control Plane (CU-CP), and an O-RAN Central Unit-User Plane (CU-UP), are described herein. In some embodiments, a reliability enhancement strategy is determined according to measurement reports collected from user equipment (UEs), the DU and the CU-UP.

公开(公告)号：US09178893B2

公开(公告)日：2015-11-03

申请号：US13444596

申请日：2012-04-11

申请人： Trent J. Miller ,  Stephen C. Glass ,  David E. Klein ,  Wei Mao ,  Francesca Schuler

发明人： Trent J. Miller ,  Stephen C. Glass ,  David E. Klein ,  Wei Mao ,  Francesca Schuler

IPC分类号： H04L29/06 ,  H04W76/00 ,  H04W12/02 ,  H04W12/04 ,  H04W84/18 ,  H04W88/06 ,  H04W88/18

CPC分类号： H04L63/104 ,  H04L63/205 ,  H04W12/02 ,  H04W12/04 ,  H04W76/45 ,  H04W84/18 ,  H04W88/06 ,  H04W88/182

摘要： A method for rapid peer-to-peer link establishment among a set of mobile devices includes operating a first second device, advertising system attributes in a wireless beacon by the second device, receiving the system attributes from the wireless beacon at the first device, comparing the system attributes to a service needed by the first device, and, if the second device is compatible based on the comparing, establishing a wireless link by the first device to the second device. A system and wireless device for rapid peer-to-peer link establishment among a set of mobile devices are also described.

摘要翻译： 一种用于在一组移动设备之间快速对等链路建立的方法包括操作第一个第二设备，由第二设备在无线信标中的广告系统属性，从第一设备的无线信标接收系统属性，比较 所述系统属于所述第一设备所需的服务，并且如果所述第二设备基于所述比较来兼容，则将所述第一设备的无线链路建立到所述第二设备。 还描述了用于在一组移动设备之间快速对等链路建立的系统和无线设备。

公开(公告)号：US08886244B2

公开(公告)日：2014-11-11

申请号：US13289074

申请日：2011-11-04

申请人： Trent J. Miller ,  Ethan Y. Chen ,  Wei Mao ,  Francesca Schuler ,  Steven E. Vanswol

发明人： Trent J. Miller ,  Ethan Y. Chen ,  Wei Mao ,  Francesca Schuler ,  Steven E. Vanswol

IPC分类号： H04B7/00 ,  H04W4/10 ,  H04W76/00

CPC分类号： H04W4/10 ,  H04W76/45

摘要： Critical resource data (192) required for a group call can be identified. Controlling (115) and secondary (155) PTT communications systems can communicate using an expanded network-to-network interface (NNI) (140). Allocation of identified critical resources (150) can be requested (145) for the group call from the secondary PTT communications system (155). In response to a successful allocation of the requested critical resources by the secondary PTT communications system, the group call can be authorized by the controlling PTT communications system (115). The allocated critical resources of the secondary PTT communications system (155) can be used to establish the group call.

摘要翻译： 可以识别组呼叫所需的关键资源数据（192）。 控制（115）和次要（155）PTT通信系统可以使用扩展的网络到网络接口（NNI）进行通信（140）。 可以对来自辅助PTT通信系统（155）的组呼叫请求（145）所识别的关键资源（150）的分配（145）。 响应于通过辅助PTT通信系统成功分配所请求的关键资源，组呼可以由控制PTT通信系统（115）授权。 辅助PTT通信系统（155）的分配的关键资源可以用于建立组呼。

公开(公告)号：US20130123719A1

公开(公告)日：2013-05-16

申请号：US13295044

申请日：2011-11-12

申请人： Wei Mao ,  Henning Hayn ,  Jelena Madic ,  Ralf Schellin

发明人： Wei Mao ,  Henning Hayn ,  Jelena Madic ,  Ralf Schellin

IPC分类号： A61M35/00

CPC分类号： G06F19/3456 ,  A61K9/7023 ,  A61M35/00

摘要： A medication patch compliance control unit system and method is disclosed. The control unit can include an attachment sensor, a user interface and a controller that receives signals from the attachment sensor and sends signals to the user interface. The control unit can include an attachment sensor, a wireless transceiver and a controller that receives signals from the attachment sensor and sends signals through the transceiver. The attachment sensor can be a temperature sensor, and the controller can determine attachment based on whether the sensor is reading temperatures in the normal body temperature range. The user interface can include visual and/or audible indicators. The control unit can include an expiration timer, and provide an expiration signal when the patch is expired. The transceiver can transmit medication patch data to a healthcare provider. The controller can record when the medication patch is attached to and detached from the patient.

摘要翻译： 公开了一种药物补丁依从性控制单元系统和方法。 控制单元可以包括附件传感器，用户界面和控制器，其从附件传感器接收信号并向用户界面发送信号。 控制单元可以包括附件传感器，无线收发器和控制器，其从附件传感器接收信号并通过收发器发送信号。 附件传感器可以是温度传感器，并且控制器可以基于传感器是否读取正常体温范围内的温度来确定附件。 用户界面可以包括视觉和/或听觉指示符。 控制单元可以包括到期定时器，并且当补丁过期时提供到期信号。 收发器可以向医疗保健提供者传送药物补丁数据。 控制器可以记录药膏贴在患者身上并从病人身上脱离的位置。

公开(公告)号：US20120290700A1

公开(公告)日：2012-11-15

申请号：US13554992

申请日：2012-07-20

申请人： Xiaodong Li ,  Wei Mao ,  Ye Tian ,  Wei Wang ,  Tao Chen ,  Di Ma

发明人： Xiaodong Li ,  Wei Mao ,  Ye Tian ,  Wei Wang ,  Tao Chen ,  Di Ma

IPC分类号： G06F15/16

CPC分类号： H04L61/6059 ,  H04L61/10 ,  H04L61/103 ,  H04L61/2007 ,  H04L61/6068

摘要： Embodiments of the present invention provide an Internet address information processing method, apparatus and an Internet system. The method includes: receiving, by a first leaf node, a query request message containing an IP address to be queried sent by user equipment, and performing query or sending a query request to an intermediate layer node; obtaining, by the intermediate layer node, an IP address of a second leaf node according to a prefix of the IP address to be queried to send the query request message to the second leaf node; and finally, sending, by the second leaf node, address information about the IP address after receiving the query request message. Embodiments of the present invention further provide corresponding apparatus and system. The method, apparatus, and system provided by the present invention are capable of implementing real-time query for address information about IP addresses.

摘要翻译： 本发明的实施例提供一种因特网地址信息处理方法，装置和因特网系统。 该方法包括：由第一叶节点接收包含由用户设备发送的要查询的IP地址的查询请求消息，并向中间层节点执行查询或发送查询请求; 根据要查询的IP地址的前缀，由中间层节点获取第二叶节点的IP地址，以向第二叶节点发送查询请求消息; 最后，在接收到查询请求消息之后，由第二叶节点发送关于IP地址的地址信息。 本发明的实施例还提供相应的装置和系统。 本发明提供的方法，装置和系统能够实现关于IP地址的地址信息的实时查询。

公开(公告)号：US20120179826A1

公开(公告)日：2012-07-12

申请号：US13496071

申请日：2010-05-11

申请人： Tong Leng ,  Zhining Ye ,  Wei Mao ,  Chengxu Zhu ,  Lu Gao

发明人： Tong Leng ,  Zhining Ye ,  Wei Mao ,  Chengxu Zhu ,  Lu Gao

IPC分类号： G06F15/173

CPC分类号： H04L61/2076 ,  H04L61/2007 ,  H04L61/2061

摘要： An address distribution method is disclosed by the present invention, in which two Broadband Remote Access Servers (BRAS) which are mutually backup devices respectively occupy part of the address resources in a shared address pool, and the method includes: when detecting a user online, a BRAS selecting an address from the corresponding part of address resources in the shared address pool and distributing the address to the user; and the BRAS sending a notification message to the backup device, and informing the backup device of the address occupied by the user. A BRAS and an address distribution system is further disclosed by the present invention, and the problem of address collision generated when a pair of BRASs which are mutually backup devices distribute the addresses to their respective user in the dual-server hot backup scenario is solved by the method, device and system of the present invention.

摘要翻译： 本发明公开了一种地址分配方法，其中相互备份设备的两个宽带远程访问服务器（BRAS）分别占用共享地址池中的一部分地址资源，该方法包括：当在线检测用户时， BRAS从共享地址池中的地址资源的对应部分中选择一个地址，并将该地址分配给用户; BRAS向备份设备发送通知消息，并向备份设备通知用户占用的地址。 通过本发明进一步公开了BRAS和地址分配系统，并且当在双服务器热备份场景中将相互备份设备的一对BRAS分配给其各自的用户时产生的地址冲突问题由 本发明的方法，装置和系统。