公开(公告)号：US09658220B2

公开(公告)日：2017-05-23

申请号：US13922821

申请日：2013-06-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US20130345081A1

公开(公告)日：2013-12-26

申请号：US13922821

申请日：2013-06-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N33/543

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

Abstract translation: 本公开提供了可用于标准化测定中检测到的信号量的组合物和方法，例如免疫测定。 组合物和方法可用于提高免疫测定的准确性，例如检测受试者是否感染逆转录病毒如HIV的免疫测定。

公开(公告)号：US09797902B2

公开(公告)日：2017-10-24

申请号：US15492905

申请日：2017-04-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/569 ,  G01N33/543 ,  C12N9/10 ,  C12N11/14

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US20170234877A1

公开(公告)日：2017-08-17

申请号：US15492905

申请日：2017-04-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N33/569 ,  C12N9/10 ,  C12N11/14 ,  G01N33/543

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US10191039B2

公开(公告)日：2019-01-29

申请号：US15710334

申请日：2017-09-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  C12N9/10 ,  C12N11/14

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US09383354B2

公开(公告)日：2016-07-05

申请号：US14598091

申请日：2015-01-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： William F. Link ,  Renato B. del Rosario ,  Randy Sweet ,  David L. King

IPC: C12Q1/04 ,  G01N33/53 ,  G01N33/536 ,  G01N33/543 ,  G01N33/532

CPC classification number: G01N33/54306 ,  G01N33/532

Abstract: An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in the assay, the reagent further comprising a corresponding unlabeled anti-antibody in an excess or near excess concentration with respect to their binding partners.

公开(公告)号：US20180011093A1

公开(公告)日：2018-01-11

申请号：US15710334

申请日：2017-09-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N33/569 ,  C12N9/10 ,  C12N11/14 ,  G01N33/543

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US20150126408A1

公开(公告)日：2015-05-07

申请号：US14598091

申请日：2015-01-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： William F. Link ,  Renato B. Del Rosario ,  Randy Sweet ,  David L. King

IPC: G01N33/543

CPC classification number: G01N33/54306 ,  G01N33/532

Abstract: An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in the assay, the reagent further comprising a corresponding unlabeled anti-antibody in an excess or near excess concentration with respect to their binding partners.