公开(公告)号：US20240093162A1

公开(公告)日：2024-03-21

申请号：US17930965

申请日：2022-09-09

Applicant: Curie Co. Inc.

Inventor： Erika M. MILCZEK ,  Robert DICOSIMO ,  Steven WALSH ,  Malcolm MCCRAY

IPC: C12N9/10 ,  C12N9/48 ,  C12N11/18

CPC classification number: C12N9/1044 ,  C12N9/48 ,  C12N9/485 ,  C12N11/18 ,  C12Y203/02013

Abstract: Immobilized proteases for activation of the zymogen form of transglutaminase are disclosed.

公开(公告)号：US20240065282A1

公开(公告)日：2024-02-29

申请号：US18035263

申请日：2021-11-04

Applicant: New Culture Inc.

Inventor： Inja RADMAN ,  Rebecca REITH ,  Neil ADAMES ,  Patrick STODDARD ,  Dilrajkaur PANFAIR

IPC: A23C20/00 ,  C12N9/10 ,  C12N15/70 ,  C12N15/74 ,  A23J3/10 ,  A23J3/34 ,  A23J3/22 ,  A23J3/28

CPC classification number: A23C20/00 ,  C12Y203/02013 ,  C12N9/1044 ,  C12N15/70 ,  C12N15/74 ,  A23J3/10 ,  A23J3/344 ,  A23J3/222 ,  A23J3/225 ,  A23J3/285 ,  C12N2800/101

Abstract: Provided herein are micelle and micelle-like compositions and the methods of making the same. The micelle and micelle-like compositions may be used to form dairy-like products.

公开(公告)号：US20230322902A1

公开(公告)日：2023-10-12

申请号：US17914139

申请日：2021-03-24

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Theanne Schiros ,  Chui Lian Lee ,  Valentina Gomez ,  Morgana Katterm ,  Helen H. Lu ,  Alie Obermeyer ,  Philip Brudnicki ,  Sebastian S. Cocioba ,  Christopher Z. Mosher ,  Romare M. Antrobus ,  Yuncan Zuh ,  Aditi Sharma

IPC: C07K14/78 ,  C07K14/435 ,  C09K11/06 ,  C12N9/10 ,  D01F4/00

CPC classification number: C07K14/78 ,  C07K14/43595 ,  C09K11/06 ,  C12N9/1044 ,  C12Y203/02013 ,  D01F4/00 ,  C09K2211/1466 ,  D10B2401/12

Abstract: A biopolymer composition can be formed based, at least in part, on a recombinantly expressed protein, expressed from a DNA coding sequence of a source protein, and the recombinantly expressed protein can optionally comprise one or more tags that enhance the crosslinking capacity of the protein. It was determined that such biopolymer composition can be suitable for use to obtain, for example, a biodegradable textile that exhibits a functional characteristic associated with the recombinantly expressed protein.

公开(公告)号：US11753669B2

公开(公告)日：2023-09-12

申请号：US17159655

申请日：2021-01-27

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Jared Spidel ,  Earl Albone

IPC: C07K16/00 ,  C12P21/02 ,  A61K47/68

CPC classification number: C12P21/02 ,  A61K47/68 ,  A61K47/6803 ,  A61K47/6811 ,  C07K16/00 ,  C12Y203/02013 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55

Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.

公开(公告)号：US20230263904A1

公开(公告)日：2023-08-24

申请号：US18188991

申请日：2023-03-23

Applicant: ARARIS BIOTECH AG

Inventor： Philipp SPYCHER ,  Philipp PROBST ,  Isabella ATTINGER-TOLLER ,  Romain BERTRAND ,  Ramona STARK ,  Dragan GRABULOVSKI

IPC: A61K47/68 ,  C12N9/10 ,  A61P35/00

CPC classification number: A61K47/6889 ,  C12Y203/02013 ,  C12N9/1044 ,  A61P35/00

Abstract: The present invention relates to a method for generating an antibody-payload conjugate by means of a microbial transglutaminase (MTG). The method comprises a step of conjugating a linker comprising the structure (shown in N->C direction) (Sp1)-RK-(Sp2)-B-(Sp3) or (Sp1)-B-(Sp2)-RK-(Sp3) to a Gln residue comprised in an antibody, wherein (Sp1) is a chemical spacer or is absent; (Sp2) is a chemical spacer or is absent; (Sp3) is a chemical spacer or is absent; R is arginine or an arginine derivative or an arginine mimetic; K is lysine or a lysine derivative or a lysine mimetic; B is a linking moiety or a payload; and wherein the linker is conjugated to the Gin residue comprised in the antibody via a primary amine comprised in the side chain of the lysine residue, the lysine derivative or the lysine mimetic. Further, the invention relates to antibody-linker conjugates, antibody-drug conjugates and linker constructs comprising an RK motif.

公开(公告)号：US09888699B2

公开(公告)日：2018-02-13

申请号：US13318881

申请日：2010-05-04

Applicant: Päivi Myllärinen ,  Kirsi Rajakari

Inventor： Päivi Myllärinen ,  Kirsi Rajakari

IPC: A23C9/00 ,  A23C9/14 ,  A23C9/12 ,  A23C9/13 ,  A23L33/26

CPC classification number: A23C9/14 ,  A23C9/1206 ,  A23C9/1216 ,  A23C9/1307 ,  A23L33/26 ,  A23V2002/00 ,  C12Y203/02013 ,  A23V2200/3322 ,  A23V2200/3324

Abstract: The invention relates to a low-energy, low-fat or fat-free, high-protein soured or unsoured product prepared by means of a crosslinking enzyme, and to a process for the preparation thereof.

公开(公告)号：US09775884B2

公开(公告)日：2017-10-03

申请号：US12532547

申请日：2008-03-21

Applicant: Shinichi Miyagawa ,  Tatsuya Araki ,  Tsutomu Hamuro ,  Mika Okuda ,  Hiroshi Kaetsu

Inventor： Shinichi Miyagawa ,  Tatsuya Araki ,  Tsutomu Hamuro ,  Mika Okuda ,  Hiroshi Kaetsu

IPC: A61K38/36 ,  A61K31/198 ,  A61K38/38 ,  A61K38/48 ,  A61L24/10 ,  A61L31/04 ,  A61K38/45 ,  A61K38/57

CPC classification number: A61K38/363 ,  A61K31/198 ,  A61K38/38 ,  A61K38/45 ,  A61K38/4833 ,  A61K38/57 ,  A61L24/106 ,  A61L31/046 ,  C12Y203/02013 ,  C12Y304/21005 ,  A61K2300/00

Abstract: A fibrinogen preparation is provided which has an improved solubility, may be prepared within a short time and may be used rapidly in clinical set-up. A solid fibrinogen preparation comprising as a main ingredient fibrinogen and further containing the following components: albumin; a nonionic surfactant; a basic amino acid or a salt thereof; and at least two amino acids or a salt thereof selected from an acidic amino acid or a salt thereof and a neutral amino acid or a salt thereof. The solid fibrinogen composition of the present invention may be held on a medical material to form a supporting material holding fibrinogen. Besides, the supporting material holding fibrinogen may be combined with a component comprising as a main ingredient thrombin to provide a fibrin adhesive.

公开(公告)号：US09676641B2

公开(公告)日：2017-06-13

申请号：US14605320

申请日：2015-01-26

Applicant: SynPhaGen LLC.

Inventor： Todd Bernard Parsley ,  Christian Furlan Freguia

IPC: A61K35/76 ,  C12N7/01 ,  C12N7/04 ,  C12N15/63 ,  C02F3/34 ,  C12N15/86 ,  C12N15/113 ,  C12N15/11

CPC classification number: C02F3/34 ,  A01N63/02 ,  A61K38/2066 ,  A61K38/45 ,  A61K38/482 ,  A61K48/005 ,  C12N7/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/70 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/32 ,  C12N2330/50 ,  C12N2795/00021 ,  C12N2795/00031 ,  C12N2795/00032 ,  C12N2795/00043 ,  C12N2795/14143 ,  C12N2820/55 ,  C12Y201/02001 ,  C12Y203/02013

Abstract: Compositions for a phage particle are disclosed. The phage particle is non-replicating and includes at least one heterologous nucleic acid sequence that is capable of being expressed in a target bacteria. The expressed heterologous nucleic acid sequence is non-lethal to the target bacteria.

公开(公告)号：US09658220B2

公开(公告)日：2017-05-23

申请号：US13922821

申请日：2013-06-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： David King ,  William F. Link ,  Renato del Rosario ,  Michael Leos

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569

CPC classification number: G01N33/543 ,  C12N9/1044 ,  C12N11/14 ,  C12Y203/02013 ,  G01N33/54393 ,  G01N33/56988

Abstract: The present disclosure provides compositions and methods that are useful for normalizing the amount of signal detected in an assay, such as an immunoassay. The compositions and methods are useful for improving the accuracy of immunoassays, such as immunoassays that detect whether a subject is infected with a retrovirus such as HIV.

公开(公告)号：US20170112751A1

公开(公告)日：2017-04-27

申请号：US15399347

申请日：2017-01-05

Applicant: AJINOMOTO CO., INC.

Inventor： Keiichi YOKOYAMA ,  Eiko OSHIMURA ,  Masayo DATE ,  Yukiko UMEZAWA

IPC: A61K8/66 ,  A61K8/34 ,  A61K8/44 ,  A61K8/41 ,  A61Q5/04 ,  A61Q5/06

CPC classification number: A61K8/66 ,  A61K8/34 ,  A61K8/416 ,  A61K8/44 ,  A61K2800/30 ,  A61K2800/4322 ,  A61Q5/00 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q5/065 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q19/00 ,  C12N9/80 ,  C12Y203/02013 ,  C12Y305/01 ,  C12Y305/01044

Abstract: A method for perming or coloring hair, in which hair is treated with a cosmetic composition including a protein-glutaminase and not including an alkaline substance. A method of enhancing hair-permeation of an active ingredient included in a cosmetic composition, in which a protein glutaminase is included in the cosmetic composition. The cosmetic composition does not include an alkaline substance, and the active ingredient is at least one of a hair perm agent and a hair coloring agent.