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公开(公告)号：US20140235556A1
公开(公告)日：2014-08-21
申请号：US14347339
申请日：2012-09-25
发明人： Reza Halse , Saurabh Saha , Jeffrey James Roix
IPC分类号： A61K38/13 , A61K31/4184 , A61K31/41 , A61K45/06 , A61K31/235 , A61K31/675 , A61K31/167 , A61K31/197 , A61K31/4188 , A61K38/08
CPC分类号： A61K38/08 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/197 , A61K31/235 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/42 , A61K31/433 , A61K31/4422 , A61K31/472 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/675 , A61K38/12 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a glioma. Methods of this invention include administering to a subject in need thereof an effective amount of a first active agent, such as e.g., an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an α2δ voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an a2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, or combinations thereof, and a second active agent, which is a chemotherapeutic agent. Compositions for treating or ameliorating the effects of a glioma are also provided.
摘要翻译： 本发明尤其提供了用于治疗或改善胶质瘤的作用的方法。 本发明的方法包括向有需要的受试者施用有效量的第一活性剂，例如血管紧张素受体阻断剂，抗真菌剂，双膦酸盐，催产素抑制剂，白细胞介素-1（IL-1） 抑制剂，环氧合酶抑制剂，α2δ电压依赖性钙通道（VDCC）抑制剂，二氢乳清酸脱氢酶抑制剂，钙通道阻滞剂，肾钠氯化合物抑制剂，α2肾上腺素能激动剂，吩噻嗪抗精神病药，钙调磷酸酶抑制剂， 5-HT激动剂，血管紧张素转换酶（ACE）抑制剂，直接肾素抑制剂或其组合，以及作为化学治疗剂的第二活性剂。 还提供了用于治疗或改善胶质瘤的作用的组合物。
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公开(公告)号：US09757424B2
公开(公告)日：2017-09-12
申请号：US14347339
申请日：2012-09-25
发明人： Reza Halse , Saurabh Saha , Jeffrey James Roix
IPC分类号： A61K31/4184 , A61K38/08 , A61K45/06 , A61K31/41 , A61K31/4188 , A61K38/13 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/197 , A61K31/235 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4168 , A61K31/4178 , A61K31/42 , A61K31/433 , A61K31/4422 , A61K31/472 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/675 , A61K38/12
CPC分类号： A61K38/08 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/197 , A61K31/235 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/42 , A61K31/433 , A61K31/4422 , A61K31/472 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/675 , A61K38/12 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a glioma. Methods of this invention include administering to a subject in need thereof an effective amount of a first active agent, such as e.g., an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an α2δ voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an a2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, or combinations thereof, and a second active agent, which is a chemotherapeutic agent. Compositions for treating or ameliorating the effects of a glioma are also provided.
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