公开(公告)号：US20250108008A1

公开(公告)日：2025-04-03

申请号：US18762297

申请日：2024-07-02

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US12059498B2

公开(公告)日：2024-08-13

申请号：US17170826

申请日：2021-02-08

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  B82Y5/00 ,  A61K48/00

CPC classification number: A61K9/1272 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US20240269040A1

公开(公告)日：2024-08-15

申请号：US18563738

申请日：2022-05-25

Applicant: BioNTech SE

Inventor： Ferdia Bates ,  Karina Nawrath ,  Christian Panhans ,  Marco Prehn ,  Ralph Krause ,  Christian Friebe ,  Moritz Kuhn ,  Frank Schoepe ,  Thomas Oppelt

IPC: A61J1/16 ,  A61J1/10

CPC classification number: A61J1/16 ,  A61J1/10

Abstract: A device (100) for accelerating thawing of a content of one or a plurality of containers (160) is provided and an associated method.

公开(公告)号：US20230390485A1

公开(公告)日：2023-12-07

申请号：US18180073

申请日：2023-03-07

Applicant: Genentech ,  BioNTech SE

Inventor： Robert Daniel OVADIA ,  Christopher Andrew Petry ,  Fredric John Lim ,  Heinrich Haas ,  Sebastian Hoerner ,  Ferdia Bates ,  Tobias Kind ,  Peer Andre Berger

IPC: A61M5/142

CPC classification number: A61M5/14228 ,  A61M2205/07

Abstract: Provided herein are methods and systems for use with peristaltic pumps. More particularly, provided herein are peristaltic pump systems that include a dampener for reducing the pulsations of the flowrate from the peristaltic pump system to produce, mix, transfer and/or manufacture pharmaceutical compositions and formulations, including pharmaceutical compositions and formulations comprising lipids and RNA.