公开(公告)号：US20250108008A1

公开(公告)日：2025-04-03

申请号：US18762297

申请日：2024-07-02

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.

公开(公告)号：US12059498B2

公开(公告)日：2024-08-13

申请号：US17170826

申请日：2021-02-08

Applicant: BioNTech SE

Inventor： Heinrich Haas ,  Sebastian Hörner ,  Isaac Hernan Esparza Borquez ,  Thomas Michael Hiller ,  Ferdia Bates

IPC: A61K9/127 ,  A61K31/713 ,  B82Y5/00 ,  A61K48/00

CPC classification number: A61K9/1272 ,  A61K31/713 ,  A61K48/00 ,  B82Y5/00

Abstract: The present disclosure relates to methods for preparing RNA lipoplex particles for delivery of RNA to target tissues after parenteral administration, in particular after intravenous administration, and compositions comprising such RNA lipoplex particles. The present disclosure also relates to methods which allow preparing RNA lipoplex particles in an industrial GMP-compliant manner. Furthermore, the present disclosure relates to methods and compositions for storing RNA lipoplex particles without substantial loss of the product quality and, in particular, without substantial loss of RNA activity.