公开(公告)号：US20240002471A1

公开(公告)日：2024-01-04

申请号：US18303642

申请日：2023-04-20

Applicant: BioNTech SE

Inventor： Ugur Sahin ,  Bonny Gaby Lui ,  Nadja Salomon ,  Joycelyn Wüstehube-Lausch ,  Matin Daneschdar ,  Hans-Ulrich Schmoldt ,  Markus Fiedler

IPC: C07K14/78 ,  C07K1/107 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07K14/78 ,  C07K1/1075 ,  G01N33/574 ,  G01N33/68 ,  A61K38/00

Abstract: The present invention relates to the diagnosis and treatment of diseases expressing Fibronectin Extra Domain B (EDB) such as diseases characterized by tissue remodeling and/or angiogenesis, in particular cancerous diseases, such as head and neck, brain, colorectal, lung, prostate and breast cancer. More particularly, the invention concerns peptides targeting Fibronectin Extra Domain B.

公开(公告)号：US20230406902A1

公开(公告)日：2023-12-21

申请号：US18316893

申请日：2023-05-12

Applicant: BioNTech SE ,  Tron-Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz ,  JPT Peptide Technologies GmbH

Inventor： Ugur Sahin ,  Matin Daneschdar ,  Hans-Ulrich Schmoldt ,  Laura-Marie Kring (née Plum) ,  Markus Fiedler ,  Ulf Reimer ,  Karsten Schnatbaum

IPC: C07K14/705 ,  G01N33/53 ,  C07K7/64 ,  A61K38/12 ,  A61K38/08 ,  A61K39/00 ,  G01N33/574

CPC classification number: C07K14/705 ,  G01N33/5308 ,  C07K7/64 ,  A61K38/12 ,  A61K38/08 ,  A61K39/0005 ,  G01N33/57492 ,  G01N2500/04 ,  G01N2333/705 ,  G01N2500/02

Abstract: The present invention provides molecules that mimic antigenic determinants of the integral transmembrane protein claudin 18.2 (CLDN18.2). These molecules compete with CLDN18.2 for binding to a CLDN18.2 binding domain, e.g. a CLDN18.2 binding domain of an antibody, and are capable of detecting antibodies against CLDN18.2. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Furthermore, they can be used for purposes of detecting agents comprising a CLDN18.2 binding domain in biological samples as well as for purifying agents comprising a CLDN18.2 binding domain.

公开(公告)号：US11673939B2

公开(公告)日：2023-06-13

申请号：US16972794

申请日：2019-06-06

Applicant: BioNTech SE

Inventor： Ugur Sahin ,  Bonny Gaby Lui ,  Nadja Salomon ,  Joycelyn Wüstehube-Lausch ,  Matin Daneschdar ,  Hans-Ulrich Schmoldt ,  Markus Fiedler

IPC: C07K14/78 ,  C07K1/107 ,  G01N33/574 ,  G01N33/68 ,  A61K38/00

CPC classification number: C07K14/78 ,  C07K1/1075 ,  G01N33/574 ,  G01N33/68 ,  A61K38/00

Abstract: The present invention relates to the diagnosis and treatment of diseases expressing Fibronectin Extra Domain B (EDB) such as diseases characterized by tissue remodeling and/or angiogenesis, in particular cancerous diseases, such as head and neck, brain, colorectal, lung, prostate and breast cancer. More particularly, the invention concerns peptides targeting Fibronectin Extra Domain B.

公开(公告)号：US11046745B2

公开(公告)日：2021-06-29

申请号：US15741902

申请日：2015-07-14

Applicant: BioNTech SE ,  TRON—Translationale Onkologie an der Universitatsmedizin der Johannes Gutenberg-Universitat Mainz gGmbH ,  JPT Peptides Technologies GmbH

Inventor： Ugur Sahin ,  Laura Marie Kring ,  Markus Fiedler ,  Matin Daneschdar ,  Hans-Ulrich Schmoldt ,  Ulf Reimer ,  Karsten Schnatbaum

IPC: A61K38/08 ,  C07K7/06 ,  G01N33/566 ,  G01N33/68 ,  C07K14/725 ,  A61K47/64 ,  A61K47/66 ,  C12N15/62 ,  A61K38/00

Abstract: The present invention provides molecules that mimic antigenic determinants of the CD3 (cluster of differentiation 3) T-cell co-receptor epsilon chain (CD3ε). These molecules compete with CD3ε for binding to a CD3ε binding domain. e.g. a CD3ε binding domain of an antibody, and are capable of detecting antibodies against CD3ε. The mimotopes of the invention may be used to generate or inhibit immune responses in animals and preferably humans. Additionally, they may serve as tools for anti-CD3ε antibody purification and the detection of anti-CD3ε antibodies in biological samples.

公开(公告)号：US20210246191A1

公开(公告)日：2021-08-12

申请号：US16972794

申请日：2019-06-06

Applicant: BioNTech SE

Inventor： Ugur Sahin ,  Bonny Gaby Lui ,  Nadja Salomon ,  Joycelyn Wüstehube-Lausch ,  Matin Daneschdar ,  Hans-Ulrich Schmoldt ,  Markus Fiedler

IPC: C07K14/78 ,  C07K1/107 ,  G01N33/68 ,  G01N33/574

Abstract: The present invention relates to the diagnosis and treatment of diseases expressing Fibronectin Extra Domain B (EDB) such as diseases characterized by tissue remodeling and/or angiogenesis, in particular cancerous diseases, such as head and neck, brain, colorectal, lung, prostate and breast cancer. More particularly, the invention concerns peptides targeting Fibronectin Extra Domain B.