公开(公告)号：US20140194427A1

公开(公告)日：2014-07-10

申请号：US14201380

申请日：2014-03-07

Applicant: Biogen IDEC MA Inc.

Inventor： Jianhua CHAO

IPC: C07C69/60 ,  A61K31/235 ,  A61K31/24 ,  A61K45/06 ,  C07D295/145 ,  C07C229/36 ,  C07C69/76 ,  A61K31/5375 ,  A61K31/225

CPC classification number: C07C69/60 ,  A61K31/225 ,  A61K31/235 ,  A61K31/24 ,  A61K31/5375 ,  A61K45/06 ,  C07B59/001 ,  C07C69/533 ,  C07C69/76 ,  C07C229/36 ,  C07D295/145

Abstract: Provided is a compound of formula (I): or a pharmaceutically acceptable salt thereof. Also provided is a method of treating, prophylaxis, or amelioration of a disease, comprising administering to a subject in need of treatment for the disease an effective amount of a compound of formula (I) described herein. In one embodiment, the method is a neurodegenerative disease, such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, or Alzheimer's disease.

Abstract translation: 提供式（I）的化合物或其药学上可接受的盐。 还提供了治疗，预防或改善疾病的方法，包括向需要治疗疾病的受试者施用有效量的本文所述的式（I）化合物。 在一个实施方案中，该方法是神经变性疾病，例如多发性硬化，肌萎缩性侧索硬化，帕金森病，亨廷顿病或阿尔茨海默氏病。

公开(公告)号：US20140179779A1

公开(公告)日：2014-06-26

申请号：US14136990

申请日：2013-12-20

Applicant: Biogen IDEC MA Inc.

Inventor： Jianhua CHAO

IPC: C07C69/60 ,  C07C69/533

CPC classification number: C07C69/60 ,  A61K31/225 ,  A61K31/235 ,  A61K31/24 ,  A61K31/5375 ,  A61K45/06 ,  C07B59/001 ,  C07C69/533 ,  C07C69/76 ,  C07C229/36 ,  C07D295/145

Abstract: Provided is a compound of formula (I): or a pharmaceutically acceptable salt thereof. Also provided is a method of activating the Nrf2 pathway, comprising contacting cells with a sufficient amount of a compound of formula (I) described herein. Also provided is a method of treating a neurodegenerative disease, comprising administering to a subject in need of treatment for the neurodegenerative disease an effective amount of a compound of formula (I) described herein.

Abstract translation: 提供式（I）的化合物或其药学上可接受的盐。 还提供了激活Nrf2途径的方法，包括使细胞与足量的本文所述的式（I）化合物接触。 还提供了一种治疗神经变性疾病的方法，包括向需要治疗神经变性疾病的受试者施用有效量的本文所述的式（I）化合物。