公开(公告)号：US20150306223A1

公开(公告)日：2015-10-29

申请号：US14419968

申请日：2013-08-06

Applicant: Biogen Idec MA Inc.

Inventor： Lynn Edward Conley ,  Yinying Tao

IPC: A61K47/20 ,  A61K38/17 ,  A61K47/18 ,  C12N7/00 ,  C07K14/705

CPC classification number: A61K47/20 ,  A61K9/0019 ,  A61K38/1793 ,  A61K47/186 ,  A61K47/24 ,  C07K14/70578 ,  C07K2319/30 ,  C12N7/00 ,  C12N2710/16763 ,  C12N2740/13063

Abstract: Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.

Abstract translation: 本发明的方面提供治疗性重组蛋白制备物和制备治疗性重组蛋白的方法，所述方法包括使重组蛋白制剂与等离子体洗涤剂的临界胶束浓度或更高的洗涤剂接触。